Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity

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Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity

Souza, Gustavo D. de et al · SEDICI UNLP · 2012

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Autore / responsabile

Souza, Gustavo D. de et al

Editore

SEDICI UNLP

Anno

2012

Lingua

Inglés

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New complexes of platinum and palladium were isolated with 2,4-dinitrophenylhydrazine (2,4-DNPH). These complexes were characterized and the results shown that the ligand is coordinated to platinum or palladium by the basic nitrogen of NH2 group and have the general structure cis-[M(2,4- DNPH)2Cl2 ].H2O where M = Pt or Pd. The thermal stability of the complexes was followed in the temperature range 25-850 ºC. The antitumor activity of the synthesized compounds has been studied and the compound cis-[Pt(2,4-DNPH)2Cl2 ], was found to display cytotoxicity (IC50 = 4.6 μmol/L) against K562 tumoral cell line. This work is the first to describe the cytotoxic activity of complexes containing 2,4-dinitrophenylhydrazine Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Souza, G. D. D. E. A. (2012). Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity. http://sedici.unlp.edu.ar/handle/10915/20207

MLA

Souza, Gustavo D. de et al. "Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity." 2012. http://sedici.unlp.edu.ar/handle/10915/20207.

Chicago

Souza, Gustavo D. de et al. 2012. "Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity.". http://sedici.unlp.edu.ar/handle/10915/20207.

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Souza, G. D. D. E. A. 2012, Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/20207 [Accessed 8 Aug. 2026].

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Titolo: Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity

Autore / collaboratori: Souza, Gustavo D. de et al

Editore: SEDICI UNLP

Anno di pubblicazione: 2012

Lingua: Inglés

Soggetti

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Farmacia; Cytotoxic activity; Hydrazones; Metal-based drugs; Platinum complexes; Paladio; Hidrazonas