Novità Aiuto Accesso istituzionale
Torna ai risultati
Scheda bibliografica · Consultazione e accesso
Artículo

Chronic hepatitis C liver microenvironment: Role of the Th17/Treg interplay related to fibrogenesis

Rios, Daniela Alejandra et al · Nature Publishing Group · 2017

Testo completo ad accesso aperto
Lettura rapida. Controlla i dati essenziali della risorsa e accedi al contenuto con il pulsante principale. La scheda mostra solo le informazioni necessarie per identificare, citare e aprire l’opera.
Autore / responsabile
Rios, Daniela Alejandra et al
Editore
Nature Publishing Group
Anno
2017
ISSN
2045-2322
ISSN
2045-2322
Lingua
Inglés
Pubblicazione seriale

3D scan-based classification of Chinese young female hand morphology

Questa pubblicazione seriale contiene 688 contenuti correlati.
Vedi contenuti

Accesso alla risorsa

Apri il contenuto dall’opzione principale o scegli un’altra fonte disponibile.

CONICET Digital CONICET Digital OAI-PMH
Entrar por CONICET Digital
Accesso principale

Testo completo ad accesso aperto

Texto completo identificado como acceso abierto.
Apri testo

Riepilogo

Descripción general del contenido del recurso.

The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in adult CHC patients. CD4+ lymphocytes were predominant in the liver, with high Foxp3+ but low IL-17A+ frequency. IL-17A+ lymphocytes and IL-17A+/Foxp3+ ratio displayed association with advanced fibrosis (p = 0.0130; p = 0.0236, respectively), while Foxp3+ lymphocytes and IL-10 expression level inversely correlated with fibrosis severity (p = 0.0381, p = 0.0398, respectively). TGF-β/IL-6 ratio correlated with IL-17A+/Foxp3+ ratio (p = 0.0036, r = 0.5944) and with IL-17A+ lymphocytes (p = 0.0093; r = 0.5203). TNF-α and TGF-β were associated with hepatitis severity (p = 0.0409, p = 0.0321). Peripheral blood lymphocyte frequency was not associated with liver damage. There are functionally different immune cell populations actively involved in liver damage, but the liver cytokine milieu actually drives the pathogenesis. The intrahepatic Foxp3+ lymphocytes predominance beside the low IL-17A+ lymphocytes frequency, delineate a skewed IL-17A+/Foxp3+ balance towards Foxp3+ lymphocytes. However, the IL-17A+ lymphocytes association with advanced fibrosis denotes their role in the pathogenesis. Therefore, the interplay between Th17 and Treg conditions liver fibrogenesis. Fil: Rios, Daniela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina Fil: Valva, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina

Come citare

Elegí el formato que necesitás y copiá la referencia al portapapeles.

APA 7

Rios, D. A. E. A. (2017). Chronic hepatitis C liver microenvironment: Role of the Th17/Treg interplay related to fibrogenesis. http://hdl.handle.net/11336/75262

MLA

Rios, Daniela Alejandra et al. "Chronic hepatitis C liver microenvironment: Role of the Th17/Treg interplay related to fibrogenesis." 2017. http://hdl.handle.net/11336/75262.

Chicago

Rios, Daniela Alejandra et al. 2017. "Chronic hepatitis C liver microenvironment: Role of the Th17/Treg interplay related to fibrogenesis.". http://hdl.handle.net/11336/75262.

Harvard

Rios, D. A. E. A. 2017, Chronic hepatitis C liver microenvironment: Role of the Th17/Treg interplay related to fibrogenesis, Nature Publishing Group, available at: http://hdl.handle.net/11336/75262 [Accessed 8 Aug. 2026].

Condividi e stampa

Salva la scheda, copia il link permanente o stampala in PDF.

Esporta riferimento

Esporta il record nei formati più comuni per usarlo con un gestore bibliografico.

RIS BibTeX

Dettagli della risorsa

Informazioni bibliografiche utili per verificare che sia il materiale corretto.

Titolo
Chronic hepatitis C liver microenvironment: Role of the Th17/Treg interplay related to fibrogenesis
Autore / collaboratori
Rios, Daniela Alejandra et al
Editore
Nature Publishing Group
Anno di pubblicazione
2017
ISSN
2045-2322
ISSN
2045-2322
Lingua
Inglés

Soggetti

Esplora risorse correlate a partire da questi soggetti.

HEPATITIS C VIRUS; PATHOGENESIS; TREG; TH17; https://purl.org/becyt/ford/3.3; https://purl.org/becyt/ford/3
Copiato