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A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display

Tomatis, Carla et al · Springer · 2025

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Autore / responsabile
Tomatis, Carla et al
Editore
Springer
Anno
2025
ISSN
0343-8651
ISSN
0343-8651
Lingua
Inglés

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With the aim of developing a new vaccine candidate using a recombinant baculovirus (rBV) expressing the Junín virus (JUNV) GP1 and GP2 proteins on its surface, a pBacPAK9 vector containing the BV-GP64 signal peptide, the JUNV GP1– GP2 and the transmembrane domain of the vesicular stomatitis virus G (VSV-G) protein were synthesized. This plasmid was co-transfected with the bApGOZA bacmid into Sf9 cells. The rBV was recovered from the supernatant. Protein expression was confirmed with a human serum by Western blot and with an anti-GPC monoclonal antibody by IFI staining and virometry. In an ELISA test, mice immunized with rBV exhibited specific antibody levels that also showed neutralizing properties in a plaque reduction test compared to controls. Guinea pigs immunized with rBV and challenged with JUNV showed partial protection compared to the Candid#1 vaccine. We have developed an rBV surface display platform to validate a potential JUNV vaccine candidate. Fil: Tomatis, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Aguiar, Mara C. A. M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina

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APA 7

Tomatis, C. E. A. (2025). A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display. http://hdl.handle.net/11336/277724

MLA

Tomatis, Carla et al. "A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display." 2025. http://hdl.handle.net/11336/277724.

Chicago

Tomatis, Carla et al. 2025. "A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display.". http://hdl.handle.net/11336/277724.

Harvard

Tomatis, C. E. A. 2025, A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display, Springer, available at: http://hdl.handle.net/11336/277724 [Accessed 5 Aug. 2026].

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Titolo
A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display
Autore / collaboratori
Tomatis, Carla et al
Editore
Springer
Anno di pubblicazione
2025
ISSN
0343-8651
ISSN
0343-8651
Lingua
Inglés

Soggetti

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BACULOVIRUS; JUNV; VACCINE; SURFACE DISPLAY; https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/1
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