Antimicrobial Surfaces from Incorporated Nano-agents

Biofilm development is a survival strategy for majority of bacteria to adapt to their living environment. These biofilms are prevalent on most surfaces in nature. Microbial cells in biofilm exhibit significantly enhanced tolerance and resistance to antimicrobial challenge and host defenses. Therefore, the control and eradication of biofilm-associated diseases present a great challenge. Recently, there is considerable biomedical incentive in the development of nanoparticles with self-antibacterial activity or as antibiotic carriers. The advantages of coatings incorporating different types of nano-agents for antimicrobial surface generation are here reviewed. Although the main coatings currently used or investigated and the associated synthesis processes are individually described, emphasis is made on silver-loaded mesoporous thin coatings. Recent developments suggest that mesoporous oxide thin films (especially titania) incorporating metal nanoparticles is becoming a prime candidate for antimicrobial coatings. Fil: Municoy, Sofia. Comisión Nacional de Energía Atómica. Gerencia de Área de Investigación y Aplicaciones no Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina