Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats

In this study, the impacts of adrenalin on ovarian injury caused by ischemia reperfusion were investigated in rats. In addition, it’s been investigated whether there is a correlation between adrenergic receptors and oxidant/anti-oxidant and COX1/COX-2 levels. It’s been observed that the COX-2 level that is responsible for MDA and inflammatory reaction (which are the indicators of oxidative stress in ovarian tissue to which ischemia reperfusion was applied) increased and the COX-1 levels that are responsible for GSH (an endogenic anti-oxidant with protective impact) were depressed. Adrenalin has prevented an increase in MDA and COX-2 activity in the ovarian tissue, to which I/R was applied, and prevented a reduction in GSH and COX-1 activity. However, adrenalin failed to prevent an MDA increase in ovarian tissue, to which alpha-2 adrenergic receptor blocker yohimbine was given (I/R formed), and also failed to prevent a GSH and COX-1 decrease. Adrenalin also failed to inhibit the COX-2 activity increase in ovarian tissue, to which beta blocker was applied. As a result, stimulation of the alpha-2 adrenergic receptors in an ovarian tissue causes an anti-oxidant and protective effect, while stimulation of beta-2 adrenergic receptors causes an anti-inflammatory effect. It’s been thought that adrenalin protects the ovarian tissue against ischemia reperfusion by stimulating the alpha-2 and beta-2 adrenergic receptors. Colegio de Farmacéuticos de la Provincia de Buenos Aires