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A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, includin...

Materias / palabras clave: ageing, immunology, gerontology, geriatrics; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy; Medicine: Internal medicine: Special situations and conditions: Geriatrics

Materias / palabras clave: gerontology, ageing, life course, old age, social science, cultural studies; Social Sciences: Social sciences (General)

Materias / palabras clave: social gerontology, cognitive functioning, multimorbidity and chronic diseases, ageing and work, sociological and psychological issues of ageing, lifespan research; Medicine

Materias / palabras clave: ageing, lifecourse, social policy; Social Sciences: Communities. Classes. Races; Social Sciences: Sociology (General)

Prologue Part I: Evolutionary explanation Demography: age and stage structure Quantitative genetics and reaction norms Trade-offs Lineage-specific effects Part II: Age and size at maturity Number and size of offspring Re...

The European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria for age-related sarcopenia. EWGSOP included representatives from four particip...

Background: in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, ...

BACKGROUND: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The...

BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Di...

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 count...

BACKGROUND: Global and regional projections of mortality and burden of disease by cause for the years 2000, 2010, and 2030 were published by Murray and Lopez in 1996 as part of the Global Burden of Disease project. These...