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El trabajo en el que se basa esta tesis representa un aporte al conocimiento de nuevos elementos del metabolismo del parásito Trypanosoma cruzi. En particular, describe genes encargados de transportar metabolitos esenci...

SUMMARY: We present here Blast2GO (B2G), a research tool designed with the main purpose of enabling Gene Ontology (GO) based data mining on sequence data for which no GO annotation is yet available. B2G joints in one app...

The Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/) is an international public repository for high-throughput microarray and next-generation sequence functional genomic data sets submitted by the research...

BACKGROUND: VSEARCH is an open source and free of charge multithreaded 64-bit tool for processing and preparing metagenomics, genomics and population genomics nucleotide sequence data. It is designed as an alternative to...

High-throughput sequencing platforms are generating massive amounts of genetic variation data for diverse genomes, but it remains a challenge to pinpoint a small subset of functionally important variants. To fill these u...

The physiological and molecular mechanisms of tolerance to osmotic and ionic components of salinity stress are reviewed at the cellular, organ, and whole-plant level. Plant growth responds to salinity in two phases: a ra...

Tremendous amount of RNA sequencing data have been produced by large consortium projects such as TCGA and GTEx, creating new opportunities for data mining and deeper understanding of gene functions. While certain existin...

The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can define cellular states based on multimodal data. Here, we intro...

Polymerase chain reaction (PCR) is a basic molecular biology technique with a multiplicity of uses, including deoxyribonucleic acid cloning and sequencing, functional analysis of genes, diagnosis of diseases, genotyping ...

Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a doze...

SUMMARY: It is expected that emerging digital gene expression (DGE) technologies will overtake microarray technologies in the near future for many functional genomics applications. One of the fundamental data analysis ta...

Part I: Molecular Biology of Cancer Molecular Methods in Oncology Section 1. Amplification Techniques Section 2. RNA Interference Section 3. cDNA arrays Section 4. Tissue arrays Section 5. Cytogenetics Section 6. Bioinfo...

Materias / palabras clave: genome sequencing and analysis, functional genomics, comparative and evolutionary genomics, bioinformatics and computational genomics, regulatory and epigenomic genomics, genomic methods and technology development; Scien...

Materias / palabras clave: genomics, genome-scale analysis, functional genomics, proteomics; Technology: Chemical technology: Biotechnology; Science: Biology (General): Genetics

Materias / palabras clave: functional genomics, epigenomics, proteomics, pharmacogenomics; Medicine: Internal medicine; Science: Biology (General): Genetics

Materias / palabras clave: genome and sequence analysis, gene and protein expression, genetics and population analysis, comparative genomics, computational functional genomics, protein dynamics and function; Medicine: Internal medicine: Neuroscien...

Materias / palabras clave: gene discovery, population genetics, genome projects, comparative genomics, functional genomics, medical genetics; Science: Biology (General): Genetics

Materias / palabras clave: molecular mechanisms of cancer, cancer genomics and tumor evolution, functional and systems oncology, biomarker discovery and validation, translational and experimental therapeutics, precision oncology research; Medicine...