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There have been several studies demonstrating a relationship between vitamin D and cardiovascular disease. Vitamin D Deficiency/Insufficiency (D/I) is a common problem in chronic renal disease and also renal transplant r...

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AIM: Cardiovascular diseases are the leading cause of morbidity and mortality in chronic kidney disease (CKD). Inflammation and endothelial dysfunction contribute to the development of cardiovascular disease in CKD. Pent...

Background: Endothelial dysfunction (ED) is a key pathophysiological mechanism in cardiovascular diseases (CVD). The Endothelial Activation and Stress Index (EASIX), derived from routine laboratory markers, has been prop...

Disorders of the vessels, that cause organ demage in Essential Hypertension (HT), may returned at early stage. In this study, vascular disorders were evaluated in 225 HT patients with a mean age of 48.1±8.6 (%77.3 of th...

Abstract Introduction No-reflow phenomenon (NRP) after primary PCI in STEMI is strongly linked to early mortality and adverse events. Conventional indices such as the systemic immune-inflammation index (SII), the CRP to ...

Abstract Background Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive endothelial dysfunction and corneal edema. Reliable objective biomarkers for grading disease severity are currently evolving....

Abstract Background Endothelial cells (ECs) orchestrate vascular homeostasis and resilience but can undergo reprogramming into a mesenchymal-like phenotype through an endothelial-to-mesenchymal transition (EndMT). Crucia...

Background and objectiveEndothelial dysfunction is a key driver of cardiovascular complications in individuals with impaired glucose tolerance (IGT), with oxidative stress and inflammation playing pivotal roles in its pa...

Abstract COVID-19, caused by SARS-CoV-2, is increasingly recognized as a systemic disorder with inflammation, endothelial dysfunction, and metabolic perturbations. This study aimed to characterize metabolic changes in CO...

Insulin resistance and sympathetic activation are shown to play a role in the pathogenesis of essential hypertension. The role of sympathetic activation in essential hypertension has been documented by a variety of tec...

Hypervolemia and uremic toxins result in accelerated atherosclerosis in chronic renal failure by causing endothelial dysfunction hypertension. The vast majority of patients undergoing renal replacement therapy are hypert...

OBJECTIVE: To investigate the relationship between early stage hypertensive retinopathy (HTRP) and endothelial dysfunction (ED) in atherogenesis. MATERIAL and METHODS:Atotal of 99 subjects consisting of 73 patients di...

Magnesium is one of the 11 most abundant elements in the human body and it is required for the action of over 300 enzymes. It is the most common intracellular, bivalent cation. It is located in quite important structures...

Abstract Background Heart failure with preserved ejection fraction (HFpEF) disproportionately affects elderly women and is closely associated with central obesity and metabolic dysfunction. Although sodium-glucose co-tra...

Abstract Vascular dysfunction, including endothelial cell (EC) senescence and hypertension, is a hallmark of metabolic syndrome, yet its underlying mechanisms remain unclear. Here, we show that metabolic stress upregulat...

The aim of this study was to explore the acute effects of high-intensity interval training (HIIT) on the microvascular circulation and vascular tumor microenvironment (TME) in a patient with uveal melanoma (UM). Addition...

OBJECTIVE: Early arterial stiffness has been shown in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function. However, to our knowledge, no prospective study evaluated changes in arte...

ABSTRACT Introduction Systematic lupus erythematosus is a complex fundamental autoimmune disease with relapsing‐remitting course and spectrum of disease ranging from mild to life‐threatening illness. Approximately ha...

AIM: One of the problems in treating anemia of CRD is iron deficiency, and intravenous (IV) iron supplementation has become an accepted therapy of iron deficiency in CRD patients. However, it is known that free iron is p...

OBJECTIVE: A number of studies report CXCL-16 as a new chemokine that mediates the collection of leukocytes and adhesion of macrophages to coronary artery smooth muscle cells, and stimulates atherosclerosis. However, the...

Preeclampsia represents an unmasking of underlying vascular and metabolic vulnerability during the physiologic stress of pregnancy. Current first-trimester screening relies heavily on body mass index which incompletely c...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...

ABSTRACT Background Adolescents with type 1 diabetes (T1D) face premature atherosclerosis, but standard carotid intima‐media thickness (IMT) may lack sensitivity for the earliest vascular injuries. Since urinary albumi...