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Abstract Background Blood-based biomarkers could improve the precision of Alzheimer’s disease (AD) clinical diagnosis and expand access to targeted treatments. Therefore, we evaluated the diagnostic accuracy of plasma ...

The study was performed to compare the bioavailability of two ketoprofen capsule (50 mg) formulations: Flogofin®, as test formulation, and Profenid®, as reference formulation. The study was conducted open with randomiz...

The braincases of the abelisaurid theropod dinosaurs Abelisauruscomahuensis and Aucasaurus garridoi are described and compared. These two taxa share the presence of a floccular recess that is ‘8’-shaped, the absence ...

Abstract Objective Accurate preoperative stone size assessment is crucial for predicting outcomes after percutaneous nephrolithotomy (PCNL), yet a gap persists between the accurate but impractical gold standard (3D softw...

Abstract Immunotherapy has transformed melanoma treatment, yet only a subset of patients benefit and clinically effective biomarkers remain limited. Here, we report a comprehensive analysis evaluating CD27 as a predictiv...

BackgroundNon-suicidal self-injury (NSSI) is common among adolescents and young adults and remains difficult to detect early using conventional approaches. machine learning (ML) has increasingly been applied to develop p...

Abstract Background Clinical findings of glucocorticoid‐deficient hypoadrenocorticism (GDH) can overlap with other diseases, presenting a diagnostic challenge. Objectives Describe clinicopathologic and ultrasonographic...

Abstract Background In dogs with protein‐losing enteropathy (PLE), data on the clinical characteristics of food‐responsive PLE (FR‐PLE) remain scarce. Objective To determine the clinical characteristics of FR‐PLE...

BackgroundElderly patients with severe acute pancreatitis (SAP) have high mortality, yet reliable early risk stratification tools remain limited. The lactate-to-albumin ratio (LAR) has emerged as a potential prognostic b...

Abstract Background Urine concentration (UC) provides clinically useful information concerning hydration status and renal function of animals. Objectives To characterize the clinical performance of urine specific gravity...

Abstract Objective Our aims to compare level of serum ischemia modified albümin(IMA) between healthy and preeclamptic pregnancies and to evaluate the relationship of IMA with preeclampsia, preeclampsia severity and pe...

Abstract Objective Acute appendicitis (AA) is one of the most common causes of acute abdomen. Its diagnosis requires the combined evaluation of clinical, laboratory, and radiological findings. This study aimed to compare...

Abstract Background Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive endothelial dysfunction and corneal edema. Reliable objective biomarkers for grading disease severity are currently evolving....

Abstract Lupus retinopathy (LR) is one of the most frequent and serious ocular complications of systemic lupus erythematosus (SLE), because it may cause irreversible visual impairment. The aim of this study was to evalua...

Customer churn prediction is essential across data-driven industries such as insurance, digital banking, e-commerce, and subscription platforms, where retaining existing customers is typically more cost-effective than ac...

Abstract Background Super-enhancers are critical cis-regulatory elements that play a central role in modulating gene expression and driving cellular identity. Their dysregulation is closely associated with the developmen...

Objective: To generate synthetic Orthopantomograms (OPGs) using generative Artificial Intelligence (AI) models and to evaluate the realism of synthetic images through assessments by humans as well as AI models. Methodolo...

Abstract Background Delayed ambulation recovery following major abdominal surgery presents a significant prognostic challenge, contributes to increased morbidity, mortality, and prolonged hospital stay. Despite recommend...

Abstract Background Patients with AIDS Suffering from sepsis secondary to pulmonary infections admitted to intensive care units (ICUs) carry a high burden of morbidity and mortality. Therefore, rapid identification and t...

Abstract Background With the widespread adoption of percutaneous coronary intervention (PCI), patients experiencing acute myocardial infarction (AMI) complicated by ventricular arrhythmia (VA) continue to encounter a sig...

BackgroundChildhood obesity represents a significant global public health challenge. Accurate and rapid prediction models for identifying obesity risk in children and adolescents are essential for facilitating early prev...

Background: Acute kidney injury (AKI) is prevalent among hospitalized patients and is frequently complicated by hyperkalemia (HyperK), kidney replacement therapy (KRT), and major adverse kidney events (MAKE). Early predi...

Abstract Background Reticulocyte indices have been suggested as alternatives to transferrin saturation (TSAT) for iron status assessment in humans and dogs but they have not been evaluated thoroughly in cats. Objectives ...

BackgroundHeterozygous STAT3 protein variants acting by dominant-negative (DN), gain-of-function (GOF), or haploinsufficiency (HI) mechanisms have been associated with different clinical/immunological phenotypes. However...