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IntroductionClinical simulation has become established as a key tool in healthcare education; however, evidence regarding its multidisciplinary implementation in university hospitals, integrating distinct professional pr...

ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and...

BackgroundClinician-scientists play a vital role in advancing health and medical research and health system innovation, yet their engagement in research, alongside their clinical role, is rarely measured in a systematic ...

Team science is central to clinical and translational research; however, systematic evaluation of collaborative efforts remains inconsistent and underdeveloped. To better understand current team science evaluation practi...

Abstract Background There has been a recent push for biomedical research to incorporate more demographically, ethnically, and medically diverse cohorts – individuals whom the NIH designates as “underrepresented in bi...

Introduction and aims: Early clinical exposure (ECE) integrates students into clinical settings during theoretical learning, aiming to foster professional development. This systematic review aims to comprehensively evalu...

Fuzi, the processed lateral root of Aconitum carmichaelii Debeaux (Ranunculaceae), is a vital yet highly toxic botanical drug in traditional Chinese medicine. However, its narrow therapeutic window, driven by highly toxi...

Abstract This article discusses the grief associated with a specific form of romantic breakup, called here unexpected divorce, and its repercussions on psychotherapeutic care. Being a complex situation composed by the co...

Abstract Backgrounds Clinical trials are central in pandemic preparedness and response (PPR). This scoping review aimed to illustrate the landscape of COVID-19-related randomized controlled trials (RCTs), focusing on the...

Abstract Background Acute liver failure (ALF) is a life-threatening syndrome characterized by rapid deterioration of liver function, resulting in high mortality and posing a substantial global health burden. Human embryo...

Abstract Knee osteoarthritis (KOA) is a degenerative joint condition characterized by progressive cartilage deterioration and chronic pain, leading to functional impairment. Bone marrow-derived orthobiologics, such as bo...

Background: BPC-157 and GHK-Cu are synthetic peptides with potential in tissue repair, influencing molecular mechanisms in healing, angiogenesis and inflammation. Objective: This review synthesizes preclinical and cli...

Development of effective and safe treatments for companion animals with cancer requires the collaboration of numerous animal health professionals and the full engagement of animal owners. Establishing ‘Best Practice Re...

Background Cognitive behavioural therapy (CBT) is considered to be an effective treatment for schizophrenia. In recent years, researchers have published clinical research results on CBT for schizophrenia. However, there ...

Clinical research and real-world observational studies are essential for advancing the diagnosis and treatment of rare diseases, such as inborn errors of immunity/primary immune disorders (IEI/PID). To support efficient ...

Objectives There is evidence that treatment expectations predict treatment outcomes in pain management and other clinical conditions. However, translating these insights into clinical practice remains challenging: it is ...

Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer that has raised significant concerns due to its strong endocrine-disrupting effects, which are closely associated with developmental toxicity. While previo...

ObjectiveThis review summarizes the current evidence on the impact of isolated antiphospholipid antibody positivity (IAAP) on pregnancy outcomes. It analyzes risk differentials across antibody subtypes, synthesizes the u...

Abstract BackgroundArtificial intelligence (AI) integrated with point-of-care imaging is a promising approach to expand access in settings with limited specialist availability. However, no systematic review h...

High-quality, openly accessible clinical datasets remain a significant bottleneck in advancing both research and clinical applications within medical artificial intelligence. Case reports, often rich in multimodal clinic...

Artificial intelligence (AI) has emerged as a transformative force in modern ophthalmology, enabling rapid advances in disease detection, clinical decision support, workflow optimization, and tele-ophthalmology. Ophthalm...

Abstract: The assessment of personality disorders assumes unquestioned clinical relevance when considering the prevalence rates in the general population. Tests assessing the typical pathological traits of these disorder...

Introduction: Neonatal sepsis remains a major cause of neonatal morbidity and mortality worldwide, particularly in resource-limited settings where advanced diagnostic facilities are not readily available. The condition o...

Preeclampsia (PE) complicates 2 % to 8 % of pregnancies and remains the leading cause of perinatal maternal and neonatal mortality worldwide. Early identification of high-risk pregnancies allows for the reduction of comp...