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This study represents one of the first investigations of circular RNAs (circRNAs) in the ovaries of Tibetan sheep, with a focus on their potential role in reproductive performance. The aim was to identify circRNAs involv...

As the genomic profile across cancers varies from person to person, patient prognosis and treatment may differ based on the mutational signature of each tumour. Thus, it is critical to understand genomic drivers of cance...

With the discoveries of new hominin fossils from historically well-studied as well as poorly sampled regions, and thanks to great advances in paleogenetic studies, Asian paleoanthropology has now entered a new phase of r...

Background and Aim: Cryopreservation of boar semen is widely used for genetic conservation and artificial insemination; however, it induces oxidative stress and molecular alterations that compromise sperm function. Epige...

The objective of this study was to evaluate selective mating using distribution of extremes, among other mating strategies, on its ability to decrease the endogamy and the loss of genetic variability. The genetic simulat...

Abstract Background Porcine circovirus type 2 (PCV2) and porcine circovirus type 3 (PCV3) have emerged as significant pathogens jeopardizing the swine industry in China in recent years, and caused substantial economic lo...

Abstract Background Understanding the genetic evolution of HIV-1 Transmitted/Founder (T/F) virus is crucial for developing effective treatment and prevention strategies due to its rapid mutation and recombination rates. ...

Satellite DNA (satDNA) is a major component of the heterochromatic regions of eukaryote genomes and usually shows a high evolutionary dynamic, even among closely related species. Section Arachis (genus Arachis) is compos...

ABSTRACT The discovery of novel bioactive compounds has significant implications for diverse biotechnological applications. However, microbial genomes remain largely underexplored regarding their potential to produce sec...

Background: Liver hepatocellular carcinoma is a highly prevalent and lethal malignancy. The orphan cytokine receptor-like factor 3, although evolutionarily conserved and implicated in hematopoiesis and neuroprotection, r...

The excessive and indiscriminate use of synthetic insecticides has led to environmental pollution, wildlife destruction, and adverse effects on human health, while simultaneously giving rise to resistance in insect pest ...

Abstract Background Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is an inherited neurodegenerative disorder associated with vitamin E deficiency. In humans, polymorphisms in genes invol...

الملخص: أهداف البحث: تم التعرف على ما لا يقل عن 500 شكل جيني متعدد مرتبط بإنزيمي CYP2C19 وCYP2C18، إلا أن عددا قليلا من هذه الأشكال...

Abstract Anaplasma marginale is a vector-borne pathogen that causes a disease known as anaplasmosis. No sequenced genomes of Brazilian strains are yet available. The aim of this work was to compare whole genomes of Brazi...

The root-lesion nematode Pratylenchus vulnus parasitizes a wide range of hosts, including woody perennials such as walnut (Juglans regia) and grapevine (Vitis vinifera), significantly damaging roots and reducing yields. ...

Abstract Klebsiella oxytoca is an under-recognised opportunistic pathogen increasingly associated with severe antimicrobial-resistant infections. Here, we report the first carbapenemase-producing K. oxytoca (CPKO) isolat...

Xue Fu,1 Jiawei Dong,2 Jian Yang,2 Xiaotian Zhang,2 Shangkun Cai,2 Yiwei Zhang,2 Shenglong Lv,2 Meng Zhang2 1Department of Emergency, Hebei Medical University Third Hospital, Shijiazhuang, 050051, People’s Republic of ...

Background and AimMost infections are innocuous in most individuals, and most infectious diseases are confined to specific organs. Inborn errors of tissue-intrinsic, non-leukocytic immunity underlie some organ-specific i...

A major challenge lies in discovering, emphasizing, and characterizing human gene-disease and gene-gene associations. The limitations of data on the role of human gene products in substance use disorder (SUD) makes it ch...

Background: Barrett's esophagus (BE) represents a critical precancerous lesion arising from chronic gastroesophageal reflux disease (GERD), with significant risk of progression to esophageal adenocarcinoma. Despite advan...

ABSTRACT Carbapenem resistance mediated by blaNDM-encoded metallo-beta-lactamases is often linked to ISAba125, an insertion sequence from the IS30 family, which is widely distributed among critical and high-priority bact...

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...

Plant male sterility refers to the failure in the production of fertile pollen. It occurs spontaneously in natural populations and may be caused by genes encoded in the nuclear (genic male sterility; GMS) or mitochondria...

Abstract Freshwater adaptation from marine ancestors represents a major ecological transition in teleost evolution, yet its genomic basis remains poorly understood. The genus Brachirus is predominantly marine, although a...