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BackgroundYoung women with localized breast cancer represent a clinically distinct population with heterogeneous outcomes, yet age-specific prognostic models remain limited. Conventional risk stratification tools derived...

BACKGROUND: Hepatocellular carcinoma (HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of HCC....

Abstract Background Visceral obesity contributes to hypertension through pathways of insulin resistance and inflammation. The joint association of C-reactive protein-triglyceride-glucose index (CTI), which integrates the...

Objectives Lactylation and liquid–liquid phase separation related genes have been reported to be associated with tumor prognosis and immunity, but their specific influence on the prognosis and immune characteristics of...

Abstract Background The lipid accumulation product (LAP), which integrates waist circumference and triglyceride levels, is an effective indicator of excessive fat accumulation. This study aimed to investigate the associa...

Abstract Background Pancreatic portal hypertension (PPH) is a distinct form of sinistral (left-sided) portal hypertension, primarily resulting from pancreatic diseases such as acute or chronic pancreatitis and pancreatic...

This study evaluated the long-term outcomes of interventional therapy for transplant renal artery stenosis (TRAS). A total of 30 TRAS patients who underwent interventional treatment between February 2017 and September 20...

Background: Post-operative pulmonary hypertension (PH) following biventricular repair of congenital heart disease (CHD) remains a high-risk condition, but its prognosis and risk stratification are poorly defined. This st...

The aim of this study was to construct models of trading companies’ lifespan, in individual districts of Zachodniopomorskie Voivodship. The author verified whether the impact of the survival time of trading companies o...

Background & Aims: Atezolizumab/bevacizumab (A/B) and durvalumab ± tremelimumab (DT/D) are preferred first-line regimens for the treatment of hepatocellular carcinoma (HCC). Although both therapies share an anti-PD-...

Abstract The role of Bisphenol A (BPA) in endometrial cancer (EC) remains uncertain. In this study, we integrated toxicological prediction, network toxicology, gene expression profiling, survival analysis, and molecular ...

Objective: Bioimpedance spectroscopy (BIS) can be used to determine hypervolemia and malnutrition in chronic hemodialysis (HD) patients. In this prospective observational study, we investigated the survival predictabilit...

Abstract Introduction Cervical cerclage is an acceptable procedure in women with cervical insufficiency and is known to be effective in the prevention of preterm delivery. However, limited data exist regarding long-term ...

Abstract Background The optimal heart rate (HR) in dogs with atrial fibrillation (AF) is unknown. Impact of HR on survival needs elucidation. Hypothesis/Objectives Dogs with a 24 hours Holter‐derived meanHR ≤125 be...

Abstract Background Down syndrome (DS) is the most common chromosomal disorder associated with congenital heart disease (CHD). However, data on CHD patterns, survival, and mortality predictors among individuals with DS i...

Abstract Background Pleural Mesothelioma (PM) is an asbestos-related cancer with poor prognosis. Despite the 1992 national asbestos ban, new cases continue to occur due to the long latency of the disease. The study aim w...

Objective: To examine the associations of phenotypic age acceleration (PAA) with all-cause and cardiovascular mortality among U.S. adults at risk for heart failure. Methods: We analyzed 19,665 participants aged ≥20 ye...

Abstract Background Inpatient hypoglycemia is a serious complication in hospitalized patients with type 2 diabetes mellitus (T2DM), associated with adverse outcomes. While insulin resistance (IR) is central to hyperglyce...

BackgroundPrimary malignant bone tumors are aggressive neoplasms that frequently affect adolescents and young adults. Limb-sparing surgery (LSS) has become the preferred surgical approach when oncologically feasible; how...

IntroductionHepatocellular carcinoma (HCC) is a lethal malignancy, with hepatitis B virus (HBV) infection as its leading cause in China. Transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) ...

Abstract Background Left atrioventricular coupling index (LACI) has been recognized for its prognostic significance across various cardiovascular diseases; however, its role in non-ischemic dilated cardiomyopathy (NIDCM)...

Objective: To explore the imaging biomarkers obtained from baseline multi-modality imaging PET/CT before metastasis-directed therapy (MDT), which could offer early response prediction before MDT treatment, optimizing pat...

Abstract Background This study aims to evaluate the effectiveness and real-world applicability of total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer (LARC), focusing on pathological complete ...

Abstract Background Rapid and accurate markers to aid diagnosis of sepsis are needed in neonatal foals. The CBC variable red blood cell distribution width (RDW) to platelet ratio (RPR) is associated with inflammatory res...