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103 resultados encontrados.

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The impact of exercise on gene regulation in association with complex trait genetics
Artículo
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The impact of exercise on gene regulation in association with complex trait genetics
Nikolai G. Vetr et al · Nature Portfolio · 2024 · ISSN 2041-1723
Abstract Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or ...
LCC TENDOlNjaWVuY2U~Idioma eng
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β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
Artículo
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β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
Dongze Li et al · BMC · 2026 · ISSN 1868-7083
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...
LCC LCC:Medicine; LCC:GeneticsIdioma eng
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Comparison of the chondrogenic differentiation potential of bone marrow mesenchymal stem cells between female and male Wistar rats
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Comparison of the chondrogenic differentiation potential of bone marrow mesenchymal stem cells between female and male Wistar rats
L.P. Romão et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2024 · ISSN 1678-4162
ABSTRACT This study aimed to compare the chondrogenic differentiation potential between bone marrow mesenchymal stem cells from female (fBMSCs) and male (mBMSCs) Wistar rats. For this purpose, female and male BMSCs were ...
LCC LCC:Animal cultureIdioma eng
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GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection
Artículo
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GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection
Ortiz Wilczyñski, Juan Manuel et al · Public Library of Science · 2020 · ISSN 1553-7366
Multiple sclerosis (MS) is a highly disabling neurodegenerative autoimmune condition in which an unbalanced immune response plays a critical role. Although the mechanisms remain poorly defined, helminth infections are kn...
Idioma eng
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Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis
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Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis
Gunapati Bhargavi et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
L-arginine (ARG) availability is a critical determinant of macrophage antimicrobial capacity, as it fuels nitric oxide production and other immune effector pathways essential for restricting Mycobacterium tuberculosis (M...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Lipidomics of allantoic fluid collected by allantocentesis indicates a possible mechanism underlying partial litter loss in multifetal pregnancies of ewes
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Lipidomics of allantoic fluid collected by allantocentesis indicates a possible mechanism underlying partial litter loss in multifetal pregnancies of ewes
Tamir Alon et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Fetal mortality significantly impacts reproductive efficiency in sheep, with approximately 30% of fetuses failing to survive until lambing. In multifetal gestation, partial litter loss (PLL) occurs in 28% to 37%...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Association between the expression of amphetamine-induced behavioral sensitization and Cdk5/p35 activity in dorsal striatum
Artículo
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Association between the expression of amphetamine-induced behavioral sensitization and Cdk5/p35 activity in dorsal striatum
Mlewski, Estela Cecilia et al · American Psychological Association · 2016 · ISSN 0735-7044
Sensitization to psychostimulants is strongly influenced by the environmental context in which the drug is administered and little is known about the molecular mechanisms that regulate this process. Chronic treatment wit...
Idioma eng
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Autologous Ex Vivo Lentiviral Gene Therapy for Pediatric Patients with Severe Leukocyte Adhesion Deficiency-I Provides Sustained Efficacy with a Favorable Safety Profile
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Autologous Ex Vivo Lentiviral Gene Therapy for Pediatric Patients with Severe Leukocyte Adhesion Deficiency-I Provides Sustained Efficacy with a Favorable Safety Profile
Claire Booth et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundSevere leukocyte adhesion deficiency-I (LAD-I) results from biallelic deleterious ITGB2 variants leading to deficient/defective CD18 leukocyte expression and impaired endothelial adhesion and extravasation.Chil...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Computational multi-omics integration suggests an association between LAMA3 expression, immune suppression, and metabolic programs in pancreatic ductal adenocarcinoma
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Computational multi-omics integration suggests an association between LAMA3 expression, immune suppression, and metabolic programs in pancreatic ductal adenocarcinoma
Ruixiang Li et al · Springer · 2026 · ISSN 2730-6011
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which immune dysregulation and metabolic remodeling are common features. Laminin subunit alpha 3 (LAMA3), a component of lamini...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts
Artículo
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Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts
Joohyun Kang et al · Springer Nature · 2023 · ISSN 2636-0772
Abstract This study examined the α-glucosidase inhibitory, and apoptosis- and anti-muscular-related factors of goat meat extracts from forelegs, hind legs, loin, and ribs. The goat meat extracts were evaluated for their...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Human alpha defensin 5 expression in the human kidney and urinary tract.
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Human alpha defensin 5 expression in the human kidney and urinary tract.
John David Spencer et al · Public Library of Science (PLoS) · 2012 · ISSN 1932-6203
BackgroundThe mechanisms that maintain sterility in the urinary tract are incompletely understood. Recent studies have implicated the importance of antimicrobial peptides (AMP) in protecting the urinary tract from infect...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B
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Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B
Fangfang Li et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
BackgroundChronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) remains a major global health burden. The immune-active (IA) phase, characterized by positive Hepatitis B surface antigens (HBsAg), elevated alani...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways
Artículo
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Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways
Barrientos, Gabriela Laura et al · W B Saunders Co Ltd · 2015 · ISSN 0143-4004
Introduction: The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipoc...
Idioma eng
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Low GBX2 expression is associated with histological type B thymoma: a multi-omics analysis
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Low GBX2 expression is associated with histological type B thymoma: a multi-omics analysis
Zheng Lu et al · Springer · 2026 · ISSN 2730-6011
Abstract Objective To explore new diagnostic markers and therapeutic targets associated with the histological types of thymoma. Methods The TCGA and GEO was used to gather genomic and clinical data from thymoma patients....
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Novel Pathogenic Variant in IL2RG Affecting the Signal Peptide Results in mRNA Instability, Decreased IL2RG Expression, and Atypical Late-Onset Immunodeficiency
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Novel Pathogenic Variant in IL2RG Affecting the Signal Peptide Results in mRNA Instability, Decreased IL2RG Expression, and Atypical Late-Onset Immunodeficiency
Muslima Hussain et al · Rockefeller University Press · 2026 · ISSN 3065-8993
X-linked severe combined immunodeficiency (SCID-X1) presents as T-B+NK- SCID, due to mutations in the common γ chain (IL2RG/CD132), a shared component of several cytokine receptors. Without definitive therapy, SCID-X1 i...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Peripheral Expression of FOXP3 in Brazilian Patients with IPEX Syndrome: From FOXP3 Biomarker to Targeted FOXP3 Therapy Within the CNE3I
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Peripheral Expression of FOXP3 in Brazilian Patients with IPEX Syndrome: From FOXP3 Biomarker to Targeted FOXP3 Therapy Within the CNE3I
Leonardo Oliveira Mendonça et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by loss-of-function mutations in the FOXP3 gene, which is critical for the development of functional regulato...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Unexpected modulation of Hna phage defense activity by the symbiotic regulator NolR
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Unexpected modulation of Hna phage defense activity by the symbiotic regulator NolR
Leah M. Sather et al · American Society for Microbiology · 2025 · ISSN 0021-9193
ABSTRACT The Hna phage defense system is one of many systems that protect bacteria against bacterial viruses (phages). Hna was first discovered in the nitrogen-fixing alphaproteobacterium Sinorhizobium meliloti, which fo...
LCC LCC:MedicineIdioma eng
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Mechanistic insights into CAR-mediated repression of the HNF4α-FABP1 axis and inhibition of HepG2 cell proliferation
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Mechanistic insights into CAR-mediated repression of the HNF4α-FABP1 axis and inhibition of HepG2 cell proliferation
Zhihui Li et al · Elsevier · 2026 · ISSN 1096-1186
The constitutive androstane receptor (CAR) modulates the transcription of numerous genes involving drug metabolism, energy homeostasis, and cell proliferation. While rodent studies suggest an oncogenic role for murine CA...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine
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A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine
Daniela Barraza et al · Nature Portfolio · 2026 · ISSN 2041-1723
Abstract Vibrio cholerae is a human diarrheal pathogen and an estuarine organism that associates with both terrestrial and aquatic arthropods. Using the model terrestrial arthropod Drosophila melanogaster, we previously ...
LCC TENDOlNjaWVuY2U~Idioma eng
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C5orf46: a promising prognosis risk indicator with implication in the remodeling of KIRC and pan-cancer tumor microenvironments
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C5orf46: a promising prognosis risk indicator with implication in the remodeling of KIRC and pan-cancer tumor microenvironments
Lei Miao et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
IntroductionC5orf46 is a recently discovered tumor-progression-related gene whose function in most cancers is still unknown, especially its potential role in regulating the tumor microenvironment (TME). The aim of the st...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Cell-type differential targeting of TLR5 and TLR7 agonists and their synergistic effect as nasal mucosal adjuvants
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Cell-type differential targeting of TLR5 and TLR7 agonists and their synergistic effect as nasal mucosal adjuvants
ZHUO Kexing et al · Editorial Office of Journal of Army Medical University · 2026 · ISSN 2097-0927
Abstract Objective To compare the differential activation characteristics of Toll-like receptor 5 (TLR5) agonist KFD and Toll-like receptor 7 (TLR7) agonist R837 on nasal epithelial cells (NECs) and bone marrow-derive...
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DNA methylation around transcription start sites is not globally associated with transcription in the grain of natural and synthetic hexaploid wheat
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DNA methylation around transcription start sites is not globally associated with transcription in the grain of natural and synthetic hexaploid wheat
Meriem Banouh et al · BMC · 2026 · ISSN 1471-2229
Abstract Background Epigenetic mechanisms including DNA methylation are assumed to play crucial roles in the maintenance of genome integrity, regulation of gene expression and development, and their increasing exploitati...
LCC TENDOkJvdGFueQ~~Idioma eng
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Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis
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Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis
Juste Cioraityte et al · BMC · 2026 · ISSN 1477-7827
Abstract Background Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the dise...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~; TENDOlJlcHJvZHVjdGlvbg~~Idioma eng
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Fibroblast cellular responses to calcium hydroxyapatite-based biomaterials
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Fibroblast cellular responses to calcium hydroxyapatite-based biomaterials
Roger KIRSCHNER et al · Universidade Estadual Paulista · 2026 · ISSN 1807-2577
Abstract Introduction Calcium hydroxyapatite (CaHa) is widely used in aesthetic procedures as a collagen biostimulator. Objective This study evaluated how different concentrations of CaHA (0.5% to 2.5%) in three commer...
LCC LCC:Medicine; TENDOkRlbnRpc3RyeQ~~Idioma eng
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