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Abstract Objective To investigate the associations between thrombus Matrix Metalloproteinase-9 (MMP-9) level and the systemic inflammatory characteristics in patients with Acute Ischemic Stroke (AIS), and to evaluate the...

Abstract Background Subcortical structures are pivotal for cortico-subcortical communication, yet are highly vulnerable to stroke. Damage to these structures can produce widespread cortical dysfunction, but how subcortic...

Abstract Background Ischemic stroke (IS) remains a leading cause of death and disability worldwide. Stroke–heart syndrome, triggered by acute cerebral ischemia, causes autonomic dysfunction that can result in myocardia...

Abstract Background Selective serotonin reuptake inhibitors (SSRIs) have been proposed to support post-stroke motor recovery, but evidence for domain-specific behavioral effects and associated neural mechanisms remains l...

Abstract Background Gastrointestinal dysfunction is a common and detrimental complication following stroke, closely linked to poor outcomes. Emerging evidence implicates gut microbiota dysbiosis and intestinal barrier di...

Abstract Background Impaired upper extremity (UE) function is a major contributor to disability after stroke. Combining robotic devices with functional electrical stimulation (FES) has emerged as a promising hybrid appro...

Abstract Background The EQ‑5D is widely applied to measure patient-reported outcomes, yet its minimally important difference (MID) has not been clearly established across distinct recovery phases after stroke. This stu...

Abstract Background The lipid accumulation product (LAP), which integrates waist circumference and triglyceride levels, is an effective indicator of excessive fat accumulation. This study aimed to investigate the associa...

Abstract Objectives This study aimed to assess the agreement between carotid Doppler ultrasound (CDU) and high-resolution magnetic resonance imaging (HRMRI) in the evaluation of extracranial internal carotid artery disse...

Abstract Background Globally, stroke is a leading cause of mortality and disability, affecting approximately 15 million people annually. This study aimed to analyze hospitalizations, deaths, and thrombolysis for ischemi...

Abstract Background Metabolic syndrome (MetS) obviously increases the risk of major adverse cardiac and cerebrovascular events (MACCE) in patients with acute myocardial infarction (AMI). However, the metabolic mechanisms...

Abstract Background In China, the informed consent for thrombolysis in patients with AIS tends to be primarily signed by proxy decision-makers, generally for the family members of patients. The decision-making process is...

Abstract Background Eosinophilic fasciitis is a rare connective tissue disorder characterized by fascial inflammation and eosinophil infiltration. Thromboembolic complications in eosinophilic fasciitis are uncommon and p...

Abstract Background and purpose Claudin-5 plays a crucial role in maintaining blood-brain barrier (BBB) integrity through endothelial tight junction formation. Alternative splicing of claudin-5 within the microvascular e...

Abstract Background Ethnic disparities in ischemic stroke are substantial and differences in exposure to air pollution have been demonstrated as well. However, the role of air pollution in mediating ethnic disparities in...

Abstract Background Postoperative complications in patients with acute type A aortic dissection (ATAAD) significantly affect their prognosis. This study investigates the association between cardiopulmonary bypass(CPB) we...

Abstract Background Strict postoperative blood pressure (BP) control within a narrow range is crucial after Carotid Endarterectomy (CEA) to minimize risks like stroke and hyperperfusion syndrome. Our institution targets ...

Abstract Background Seasonal variation in cardiovascular and cerebrovascular diseases (CCD) is well documented, with higher morbidity in winter. Israel’s contrasting climates—Mediterranean in the north and semi-arid ...

Abstract Background There is little evidence on the association between cooking with polluting fuels, particularly charcoal, and heart disease from low- and middle-income countries, which have the highest burdens of poll...

Abstract Brain pericytes are mediators of neuroinflammation, as evidenced in vitro, in animal models and humans. We and others have identified the platelet-derived growth factor (PDGF)-BB -PDGF receptor beta (PDGFRB) pat...

Abstract Background This Health Impact Assessment (HIA) study aimed to explain and evaluate the impacts of the Shahid Rajaei plan (SRP) on rural older adult’s health in Piranshahr County, Iran, and offers recommendatio...

Abstract Background Posterior reversible encephalopathy syndrome is a rare neurological disorder typically associated with hypertension, cytotoxic agents, or supratherapeutic immunosuppressant levels. We report what appe...

Abstract Background Mortality rates remain high among individuals with type 2 diabetes. The rising cases of Diabetes Mellitus (DM) have negatively impacted society’s development, health and have impoverished individual...