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Background: Combining radiotherapy (RT) with immune checkpoint inhibitors (ICIs) offers potential synergy through RT-induced immunogenic cell death and enhanced systemic immunity. However, optimal RT dose, fractionation,...

Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...

Background and Purpose: Anatomical variations during prostate radiotherapy can cause discrepancies between planned and delivered doses, which may become more pronounced in (ultra-)hypofractionated regimens. However, a st...

Background and Purpose: Deep learning segmentation (DLS) and planning (DLP) models in radiotherapy treatment planning increase consistency and reduce planning time. However, many DL segmentations and plans are manually a...

Background and purpose: Image-guided radiotherapy (IGRT) for esophageal cancer requires large planning target volume (PTV) margins to account for interfraction variations, increasing radiation-associated side-effects. Co...

Background and purpose: Stereotactic radiotherapy (SRT) delivers high doses with submillimeter precision to small targets, requiring accuracy in both dose calculation and delivery. This study aimed to perform a dosimetri...

Objective: To assess the efficacy and safety of Qixuekang oral liquid in the treatment of leukopenia during chemotherapy and radiotherapy. Methods: This randomized, double-blind, placebo-controlled, multicenter clinical ...

Background and purpose: Stereotactic ablative body radiotherapy (SABR) achieves excellent local control in medically inoperable non-small cell lung cancer. However, treating central and ultra-central tumours carries sign...

Free-breathing spine-based positioning/tracking in lung stereotactic body radiotherapy is required when direct tumor positioning is not possible. Respiratory baseline, motion and target position reproducibility interact ...

This study presents the results of a multicentre external dosimetry audit conducted as part of the PROTECT trial, involving nine European radiotherapy centres delivering proton and photon treatments. A dosimetry equipmen...

Background and Purpose: Insufficient documentation of artificial intelligence (AI) models remains a widespread issue, which hampers reproducibility in research environments and safe integration in clinical departments. O...

Background and purpose: Ultra-high-dose-rate (UHDR) radiotherapy (RT) has emerged as a promising technique to widen the therapeutic window. However, clinical implementation is critically dependent on standardized dosimet...

Manual Gross Tumor Volume (GTV) delineation for radiotherapy is time‑consuming and prone to inter‑observer variability. Deep Learning (DL)-based auto‑segmentation offers faster and more consistent solutions, but tr...

Purpose: To evaluate the impact of intra- and interfractional motion on dose distribution and clinical outcome in prostate magnetic resonance (MR)-guided adaptive radiotherapy. Methods: Seventy-six patients were treated ...

Background and purpose: A dummy run quality assurance was conducted for a prospective phase II trial of tailored radiotherapy (RT) according to the response after neoadjuvant chemotherapy (NAC) followed by surgery in loc...

Background and Purpose: Craniospinal irradiation (CSI) is a critical treatment modality for central nervous system (CNS) tumors. This study aimed to compare the dose-volume parameters and treatment efficiency between O-r...

Objective: To identify risk factors for post-radiation xerostomia and to evaluate the tolerance to doses administered to the parotid gland in patients with nasopharyngeal carcinoma (NPC). Methods: A total of 462 patients...

Background and purpose: Dose accumulation in reirradiation can contribute to both treatment outcomes and safe cumulative doses. We demonstrated consensus strategies on dose accumulation for three clinical reirradiation s...

Resumen: En los últimos años, la concepción tradicional de la radioresistencia del carcinoma de células renales ha ido cambiando. Esto gracias al desarrollo de la radioterapia estereotáxica corporal (SBRT) como una ...

Background and purpose: The use of Magnetic Resonance imaging (MRI) for radiotherapy planning and guidance for locally advanced non-small cell lung cancer (LA NSCLC) is novel. The superior soft tissue definition of MRI c...

Breast cancer bone metastasis causes severe complications, yet current radiotherapy has limitations in treating secondary metastases and protecting healthy tissues. This study introduces calcium gadolinium layered double...