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As research and services in the Mediterranean region continue to increase, so do opportunities for global collaboration. To support such collaborations, the Alzheimer's Association was due to hold its seventh Alzheimer's...

Objective: To describe the Amyloid, Tau, Neurodegeneration (A/T/N) research framework classification in the Argentine-Alzheimer Neuroimaging Initiative (ADNI) cohort. Methods: 23 Mild Cognitive Impairment (MCI), 12 Alzhe...

Abstract Background The rising global aging population has increased the prevalence of Alzheimer’s disease (AD), a condition with limited treatment options, making non-pharmacological interventions essential. While mob...

Abstract Purpose This study aimed to identify the effectiveness of free water MRI (FW-MRI) features for predicting amyloid-beta (Aβ) statuses in Alzheimer’s disease (AD) by constructing diagnostic models using machine...

Abstract Background Blood-based biomarkers could improve the precision of Alzheimer’s disease (AD) clinical diagnosis and expand access to targeted treatments. Therefore, we evaluated the diagnostic accuracy of plasma ...

IntroductionAlzheimer’s disease (AD) is strongly associated with cerebrovascular dysfunction and impaired glymphatic clearance. These dysfunctions may precede, contribute to, and interact bidirectionally with AD pathol...

Abstract Background Current understanding of the fluid biomarker profile in early-onset Alzheimer’s disease (EOAD) associated with pathogenic APP variants remains limited. We characterized four EOAD pedigrees carrying ...

Background: The purpose of this study was to investigate the relationship between cognitive reserve and concentration of Aβ1-42 in the cerebrospinal fluid (CSF) of patients with mild cognitive impairment, those with Alz...

Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker of astrocytic reactivity in preclinical Alzheimer´s Disease (AD). However, most evidence to date comes from ultrasen...

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Its complex pathogenesis remains unclear, and no specific drugs are available for treatment. Current treatments focus mainly on ...

Introducción: Las pruebas de Fluencia Verbal (FV) Semántica (FVS) y Fonológica (FVF) son muy empleadas en la práctica clínica. Disponer de diferentes pruebas alternativas que además tengan en cuenta el efecto de va...

IntroductionThe long-term efficacy of electroacupuncture (EA) in treating cognitive symptoms of Alzheimer’s disease (AD) remains unclear, and its time-dependent relationship requires further investigation.MethodsSixty-...

Abstract Background Recruitment and retention remain persistent challenges in Alzheimer’s disease (AD) clinical trials, particularly as studies increasingly focus on earlier disease stages and require longer participat...

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive decline. One of the leading theories explaining AD pathology is the emergence of cortical hypo...

Abstract Alzheimer’s disease, a progressive neurodegenerative disorder, presents a growing global health challenge due to its increasing prevalence and lack of accessible early diagnostic methods. Even though it has en...

OBJECTIVE: There is epidemiological evidence of an association between occupational pesticide exposure and cognitive impairment, but studies on the link with Alzheimer`s disease are scarce. We explored the association be...

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β and tau pathology, neuroinflammation, oxidative stress, and cognitive decline. Emerging evidence indicates that ...

Abstract Background Telomere length (TL), a biomarker of biological aging, but its association with Alzheimer’s disease (AD) remains unclear. Methods We estimated TL in whole-genome sequencing data from 35,014 Alzheime...

IntroductionEarly detection of Alzheimer’s disease (AD) is critical for timely intervention, particularly during the mild cognitive impairment (MCI) stage. This study aimed to develop and evaluate a multidomain speech ...

Abstract Alzheimer’s disease (AD) is a prevalent and progressive neurodegenerative disease characterized by behavioral abnormalities, memory loss, and cognitive decline, presenting significant challenges for early diag...

Recent advances in Alzheimer’s disease research have reshaped how clinical trials are designed and interpreted, particularly through the use of targeted monoclonal antibodies, biomarker-guided enrollment, and novel dru...

Resumen: La enfermedad de Alzheimer es actualmente la principal causa de demencia en los adultos mayores. De hecho, esta enfermedad neurodegenerativa multifactorial representa aproximadamente entre el 60% y el 70% de tod...

Periodontitis is the most common condition of chronic periodontal infection and inflammation in the elderly population. Periodontal disease can cause local inflammation that contributes to higher risk of systemic inflamm...

Abstract Background ADAM10 and ADAM17, members of the membrane-bound disintegrin metalloproteinase (ADAM) family, act as α-secretases in the non-amyloidogenic processing of the amyloid precursor protein. While alteratio...