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Abstract Ebola viral disease, or simply Ebola is a fatal and highly contagious disease caused by the Ebolavirus. Macrophages and dendritic immune cells are the predominant target cells of Ebolavirus. In this present stud...

A series of trifluoromethylated hexahydropyrimidines was synthesized using Preyssler heteropoly acid H14NaP5W29MoO110 encapsulated in a silica framework as the catalyst under solvent-free conditions. This synthesis requi...

Abstract A seriers of 1, 3, 4-oxadiazol-2-thion were synthesized by the reaction of naproxen (or acetyl) amino acid hydrazides (glycine, valine, leucine, isoleucine and tyrosine) with carbon disulphide in alkaline medium...

ABSTRACT Treatment of cinchoninic acids (1a,b) with allyl bromide afforded compounds (2a,b), and the hydrolysis of (2a) gave the 2-(4`-allyloxyphenyl) cinchoninic acid (4) . Glycedylation of compound (1a) afforded compou...

IntroductionProbiotics have demonstrated positive effects on obesity and type 2 diabetes (T2D) in various studies. Postbiotics, specifically nonliving bacterial lysates derived from cell walls and DNA, are increasingly r...

This study include the synthesis of the compound 1-(1H-benzo[d]imidazol-2-yl)ethanol [1], from the reaction of ortho pheneylene diamine with lactic acid and then oxidized using potassium dichromate to give1-(1H-benzo[d]i...

Several new 1,2,5-oxadiazole N-oxide derivatives and some deoxygenated analogues were synthesized to be tested as potential selective hypoxic cell cytotoxins. Compounds prepared were designed in order to gain insight int...

Abstract 2-Mercapto benzimidazole derivatives are well-recognized for their diverse pharmacological activities, including anti-tubercular, antimicrobial, anti-ulcer, analgesic, and anticancer properties. Isoniazid, a fir...

Abstract The present study employed a three-step synthetic strategy to develop a series of novel (Z)-N-(2,4-dimethylphenyl)-3-(3-(((5-phenyl-1,3,4-thiadiazol-2-yl) imino) methyl)-1H-indol-1-yl) propanamide derivatives. T...

As a part of our project aimed at developing new safe chemotherapeutic and chemoprophylactic agents against tropical diseases, fluorine-containing drugs structurally related to 4-phenoxyphenoxyethyl thiocyanate (1) were ...

Abstract Diabetic retinopathy (DR), the most prevalent ocular complication of diabetes, progresses from non-proliferative (NPDR) to sight-threatening proliferative (PDR) stages. Current interventions—including retinal ...

The paper proposes a method for identifying aerodynamic coefficient derivatives of aircraft attitude channel using spiking neural network (SNN) and Gauss-Newton algorithm based on data obtained from actual flights. Using...

Breast cancer is one of the leading causes of mortality among women worldwide and is frequently associated with the overexpression of Estrogen Receptor alpha (ERalpha). This study aimed to evaluate the potential of imida...

Abstract 5,6-Dihydrobenzo[h]quinoline derivatives 4a–f and 5a–c were prepared via condensation of the corresponding arylidenes 2, with 1-tetralone in the presence of ammonium acetate and sodium methoxide, respectivel...

Abstract This research investigates the synthesis and characterization of a unique Cy@TC-Pd complex immobilized on CdFe2O4 nanoparticles. A palladium-based catalyst, supported on magnetite nanoparticles, was successfully...

To explore more potential fungicides with new scaffolds, 10 norbornene derivatives containing thiourea group were designed, synthesized and assayed for inhibitory activity against three plant pathogenic fungi. The prelim...

A total of 142 presumptive phage-resistant derivatives were isolated from six commercial phage-sensitive Leuconostoc mesenteroides and Leuconostoc pseudomesenteroides strains, using six phages either individually or in c...

Abstract Background Heart failure (HF) has high morbidity and mortality, worsened by aging and metabolic diseases. The triglyceride–glucose (TyG) index and its obesity-related derivatives are markers of metabolic dysfu...

ABSTRACT The diazonium salt of 4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol- 2-one (4-aminoantipyrine) was coupled with ethylacetoacetate and ethyl benzoylacetate to give the corresponding diazo compounds under basic media. ...

"Herein, we describe the syntheses of 3,5-disubstituted imidazo[2,1-b]thiazole. The cyclization step was performed in two different conditions by using either thermal or microwave heating. Comparing the results of both m...

ABSTRACT In this paper the synthesis of some 1,2,5- oxadiazino [2-3,b] quinazoline and some substituted 1,3- oxazole are reported, alanine and valine were reacted with benzoyle chloride in sodium hydroxide solution to gi...

4-Nerolidylcatechol (4-NRC) is the most abundant antioxidant product isolated from the roots of Pothomorphe umbellata (L) Miq. It displays important sunscreen protection and other pharmacological properties comprising an...

A series of novel danshensu amide derivatives were synthesized, and the protective effects of all the compounds on rat myocardial cell lines H9C2 by hypoxia were investigated. The results showed that all the seven compou...