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4-Nerolidylcatechol (4-NRC) is the most abundant antioxidant product isolated from the roots of Pothomorphe umbellata (L) Miq. It displays important sunscreen protection and other pharmacological properties comprising an...

A series of novel danshensu amide derivatives were synthesized, and the protective effects of all the compounds on rat myocardial cell lines H9C2 by hypoxia were investigated. The results showed that all the seven compou...

Fifteen 2-[(substituted-benzylidene)-amino]-5-methyl-thiophene-3-carbonitrile (3a-g) and 2-[(substituted-benzylidene)-amino]-4,5-cycloalkyl-thiophene-3-carbonitrile derivatives (4a-h) were synthesized and screened for th...

In this work the antibacterial activity of two pregnenolone-derivatives was evaluated on V. cholerae and E. coli, using a NCCLS broth dilution modified method. Additionally, to delineate the structural chemical requireme...

In the present investigation, extended release tablets of metoprolol succinate were developed using cellulose derivatives and natural gums as matrix formers and were evaluated for its extended release characteristics. Th...

Ten new 4-thiazolidinone derivatives have been synthesized from the alkanoic acids. Alkanoic acid hydrazides (I) on refluxing with aromatic aldehydes in the presence of a catalytic amount of glacial acetic acid in methan...

Six new dodecanoic acid hydrazide-hydrazones (compounds 4a–f), unsubstituted or carrying hydroxy, methoxy, nitro and chloro groups on the benzene ring, were synthesized and tested, in vitro, for their antimicrobial act...

A novel series of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1, 2, 4-triazole derivatives were synthesized by reaction of 5-substituted phenyl-3,4-diamino-1,2,4-triazole with different aromatic aldehydes. T...

A novel series of 2-hydrazolyl-3-phenyl-5-(4-nitrobenzylidene)-4-thiazolidinone substituted (3a-p) has been synthesized. The intermediates 2-hydrazolyl-3-phenyl-4-thiazolidinone substituted (2a-p) were prepared by conden...

Several phenothiazines and related compounds were synthesized and their antifungal activity was evaluated in vitro. The results observed for α-chloro-N-acetyl phenothiazine led us to choose this compound as a lead in th...

Cylin dependent kinases (CDKs) have emerged as novel mechanistic target due to their direct involvement in underlying genetic changes during the cancerous state. In order to identify the essential physiochemical paramete...

In the present study matrix and multilayered matrix tablets of diltiazem HCl were formulated by using guar gum as matrix core component and cellulose derivative, Sodium Carboxy Methyl Cellulose (SCMC) as barrier layers. ...

A simple HPLC method was developed to study the pharmacokinetics of tobramycin in rat after intravenous administration. The plasma samples were deproteinized with acetonitrile after addition of the internal standard, net...

This study reports the cytotoxicity screening of 33 coumarins in a panel of human tumor cell lines (Caco-2: human colorectal adenocarcinoma, HCT-8: human ileocecal adenocarcinoma, and HEp-2: human larynx epidermoid carci...

Cordia americana (L.) Gottschling & J.S. Mill. is a tree which belongs to the Boraginaceae family and is native to the South of Brazil, Paraguay and Argentine, where it is commonly known as guajuvira and guayaibí. In fo...

Resveratrol exhibits wide pharmacological activities, such as, anti-oxidant, anti-inflammatory, analgesic, cardio-protective, neuro-protective, chemo-preventive, chemo-therapeutic, and anti-aging. However, its aqueous so...

Various benzylideneamino-5H-thiochromeno[2,3-b]pyridin-5-one derivatives were synthesized by the reaction of 7-amino-5H-[1] benzothiopyrano[2,3-b]pyridin-5-one and different benzaldehydes. Their structures were confirmed...