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Abstract Ebola viral disease, or simply Ebola is a fatal and highly contagious disease caused by the Ebolavirus. Macrophages and dendritic immune cells are the predominant target cells of Ebolavirus. In this present stud...

IntroductionProbiotics have demonstrated positive effects on obesity and type 2 diabetes (T2D) in various studies. Postbiotics, specifically nonliving bacterial lysates derived from cell walls and DNA, are increasingly r...

Abstract 2-Mercapto benzimidazole derivatives are well-recognized for their diverse pharmacological activities, including anti-tubercular, antimicrobial, anti-ulcer, analgesic, and anticancer properties. Isoniazid, a fir...

Abstract The present study employed a three-step synthetic strategy to develop a series of novel (Z)-N-(2,4-dimethylphenyl)-3-(3-(((5-phenyl-1,3,4-thiadiazol-2-yl) imino) methyl)-1H-indol-1-yl) propanamide derivatives. T...

Abstract Diabetic retinopathy (DR), the most prevalent ocular complication of diabetes, progresses from non-proliferative (NPDR) to sight-threatening proliferative (PDR) stages. Current interventions—including retinal ...

Breast cancer is one of the leading causes of mortality among women worldwide and is frequently associated with the overexpression of Estrogen Receptor alpha (ERalpha). This study aimed to evaluate the potential of imida...

Abstract This research investigates the synthesis and characterization of a unique Cy@TC-Pd complex immobilized on CdFe2O4 nanoparticles. A palladium-based catalyst, supported on magnetite nanoparticles, was successfully...

To explore more potential fungicides with new scaffolds, 10 norbornene derivatives containing thiourea group were designed, synthesized and assayed for inhibitory activity against three plant pathogenic fungi. The prelim...

Abstract Background Heart failure (HF) has high morbidity and mortality, worsened by aging and metabolic diseases. The triglyceride–glucose (TyG) index and its obesity-related derivatives are markers of metabolic dysfu...

1,2,3-triazole represents a class of nitrogen-containing heterocyclics with a wide range of biological activity. The medicinal applications of 1,2,3-triazole derivatives, including antioxidant, antimicrobial, antiviral, ...

Abstract Marine habitat maps are essential tools for marine spatial planning, providing information for decision‐making in conservation and resource management. Accurate classification of benthic habitats supports thei...

Punjab is a predominantly agrarian state and among the least forested in India. It remains underrepresented in w ildlife crime research. This study documents thirty-two wildlife crime incidents affecting thousands of wil...

This study comprises two distinct but parallel investigations concerning Haemaphysalis longicornis in Korea: an exploratory ecological survey of vector density across 20 sites in 2023 and a laboratory-based screening of ...

This investigation focused on the compilation and analysis of the incidence of foodborne diseases and foodborne outbreaks related to protein-based foods, published in official surveillance reports from the European Union...

Stabilizers are critical additives used to ensure long-term storage stability and safe usage of nitrocellulose-based propellants (NCBPs) by mitigating their inherent chemical instability. However, conventional stabilizer...

An efficient and scalable method for the synthesis of 1,2,3-benzoxathiazole 2,2-dioxides and related five-membered cyclic sulfamates employing gaseous sulfuryl fluoride (SO2F2) in the presence of Et3N is described. The o...

Quinolines are well-established scaffolds in drug discovery and form the core of many FDA-approved medicines. Among their reduced analogues, hexahydroquinolines (HHQs) have gained increasing attention due to their struct...

In the search for new compounds for the treatment of Chagas disease, the cysteine protease cruzipain remains as one of the most attractive biomolecular targets for drug development. Thiosemicarbazones (TSCs) have been id...

The triazine backbone serves as a crucial heterocyclic scaffold in the development of energetic materials due to its high nitrogen (52%) and energy content (223 kJ/mol). Additionally, it functions as an environmentally b...

This study presents a novel regioselective synthesis of 3-electron-withdrawing-group-(EWG)-substituted 5-sulfonyl- and 5-sulfinylisoxazoles from 3-EWG-5-nitroisoxazoles via nucleophilic aromatic substitution with thiophe...