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Abstract Background The European Reference Network for rare Inherited and Congenital Anomalies (ERNICA) aims to improve care for patients with rare and complex digestive and gastrointestinal diseases across Europe throug...

Growing evidence has directly linked the gastrointestinal tract, gut microbiota, and central nervous system, forming the gut-brain axis, a process that has been described as a key mechanism in regulating neurological pro...

Abstract Objectives Gastroesophageal reflux disease (GERD) is estimated to affect up to one-quarter of the Italian population, generating immense treatment costs. An emergent surgical treatment involving implantation of ...

Abstract Objective Current diagnostic paradigms for Crohn’s disease (CD) activity assessment remain fragmented across imaging and laboratory modalities. This study seeks to investigate the diagnostic efficacy of intest...

Abstract Objective To assess the level of fear of disease progression (FoP) in patients with acute pancreatitis (AP) during early hospitalization and identify its influencing factors. Methods This cross-sectional study w...

Aim: Chronic liver disease (CLD) is characterized by progressive impairment of hepatic function and frequent lipid metabolism abnormalities, with reductions in high-density lipoprotein cholesterol (HDL-C) and other lipop...

ObjectivePancreatic disorders are characterised by high mortality rates and limited therapeutic options and pose a global health challenge. As a dual-function organ with endocrine and exocrine roles, the pancreas exhibit...

BackgroundColorectal cancer (CRC) is a common malignant tumor in the digestive system worldwide. In China, there are significant challenges in prevention and control, and there is a lack of relevant evidence regarding th...

Abstract Background Chronic idiopathic lymphoplasmacytic rhinitis (CILPR) is a common inflammatory disorder of unknown etiology affecting the nasal cavity of dogs. The diagnosis is made by exclusion of other causes of na...

Background: Multiple meta-analyses have evaluated the effect of Helicobacter pylori ( H. pylori ) infection on the risk of inflammatory bowel disease (IBD), but their findings remain inconsistent. Objectives: To critical...

Janus kinase (JAK) inhibitors represent a major advancement in the management of immune-mediated inflammatory diseases. A balanced approach that carefully weighs therapeutic benefits against potential risks is essential....

Background: The vedolizumab-specific clinical decision support tool (VDZ-CDST) was developed to predict the probability of a response to vedolizumab treatment in patients with Crohn’s disease (CD). Objective: This post...

BackgroundSurgical procedures can increase the incidence of stress ulcers. This study aims to investigate the occurrence of postoperative stress gastric ulcers in a high-altitude environment and to identify independent r...

Soybeans hold a deep cultural significance with its origin in Asia. All of the current modern cultivars belong to the same Glycine max (L.) Merrill, which can be distinguished primarily by their seed coat pigmentation. T...

Pregnancy is accompanied by complex physiological adaptations that influence hepatic metabolism, bile transport, coagulation, and immune tolerance, which may precipitate the development of pregnancy-specific liver disord...

The paper aims to analyse the trends in mortality of men and women aged 65 and more in the Lodz region in the period 1999–2013, with particular emphasis on the phenomenon of excess male mortality. A complete database o...

Introduction . Pemphigus is an autoimmune blistering disease, characterized by the presence of autoantibodies directed against desmoglein. It is a severe and potentially life-threatening skin disease, requiring prolonged...

The two principal cell types of the exocrine pancreas, acinar and ductal cells, serve distinct but complementary roles. Acinar cells synthesize and secrete digestive enzymes, whereas duct cells secrete fluid and bicarbon...

Based on the characteristics of curcumin, such as low bioavailability, low toxicity, wide availability, and multiple biological activities, and in conjunction with its established pharmacological effects on anti-platelet...

The amaranth plant, originating from Central and South America, was a staple food for ancient civilizations like the Aztecs and Inca. Today, it is cultivated across tropical and subtropical regions, including Africa, Asi...

The Developmental Origins of Health and Disease theory describes early life as a critical window for long-term metabolic health. Accumulating evidence has identified the gut microbiota as a key mediator of early-life met...

Abstract Background Mesenchymal stem cells (MSCs) have become a promising treatment of liver fibrosis which is a key process in liver diseases. Recent studies have shown that transplanted MSCs undergo rapid apoptosis and...

The gut microbiota plays a central role in modulating both immunity and metabolism. Obesity-associated microbiota configuration is a critical driver of persistent inflammatory activation and immune dysfunction, ultimatel...

Abstract Background Sorafenib has served as standard treatment for advanced hepatocellular carcinoma (HCC). Recently, several randomized controlled trials (RCTs) have explored the use of programmed cell death protein 1/p...