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Thymic stromal cells drive T cell development by supplying key cues for progenitor proliferation and differentiation. Although thymic epithelial cells are well characterized, recent studies highlight crucial functions of...

IntroductionParkinson’s disease (PD) is the second most common neurodegenerative disorder. The risk of frailty is significantly higher in patients with PD than in age-matched individuals without PD. This study aimed to...

Abstract Liver fibrosis remains an unmet medical need with limited therapeutic options and high translational failure. Conventional two-dimensional stellate cell cultures and cytokine-induced organoids poorly recapitulat...

Abstract Introduction Invasive meningococcal disease (IMD) caused by meningococcal serogroup B (MenB) is a rare but serious illness with potentially life-threatening outcomes, particularly in infants. In Brazil, IMD is ...

BackgroundPsychological adaptation to acquired disability, conceptualized as disability acceptance, is crucial for recovery after hypertensive intracerebral hemorrhage (HICH). However, the longitudinal course of disabili...

Abstract Background Social mixing studies provide crucial evidence for parameterizing mathematical models of infectious disease transmission, and their validity for use in models is dependent on their study design and ho...

Plant disease diagnosis in field settings is challenged by subtle symptomology, high inter-class visual similarity, and class imbalance, making automated detection particularly difficult. While deep learning models achie...

Abstract Background China bears a high burden of both hepatitis B virus (HBV) infection and type 2 diabetes mellitus (T2DM). T2DM accelerates the progression of liver disease among individuals infected with HBV. This stu...

Background: Latent tuberculosis infection (LTBI) remains a critical reservoir for the global tuberculosis (TB) epidemic, particularly in South Asia, where high population density and socioeconomic disparities amplify its...

Diabetic kidney disease (DKD) is one of the most severe complications of diabetes. Animal models of DKD play a crucial role in elucidating disease pathogenesis, exploring therapeutic strategies, and developing pharmacolo...

Abstract Background Chronic kidney disease (CKD) frequently causes death in older cats; its early detection is challenging. Objectives To build a sensitive and specific model for early prediction of CKD in cats using art...

Abstract Background The association between vitamin D status and mortality risk among adults with cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3 requires further elucidation. We investigated the relationship...

Abstract Background Both the atherogenic index of plasma (AIP) and obesity have been implicated in cardiovascular disease (CVD) risk. This study aimed to investigate the associations of AIP and AIP-obesity indices (AIP-W...

Pelvic inflammatory disease (PID) is a complex multifactorial infectious disorder of the female reproductive tract, associated with severe long-term sequelae including infertility, ectopic pregnancy, and chronic pelvic p...

BackgroundClimate change is increasingly recognized as a critical driver affecting the transmission and distribution of parasitic diseases. However, a comprehensive synthesis of the global research landscape in this inte...

Abstract Background Developing regenerative therapies to restore kidney function in patients with progressive renal disease represents a major challenge for modern molecular nephrology. Kidney organoids, three-dimensiona...

Abstract Background Obesity is associated with metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the rising prevalence of obesity among children and adolescents, no studies have examined risk fact...

Extended-spectrum β-lactamases (ESBLs), especially those of the CTX-M family, significantly contribute to antibiotic resistance in Escherichia coli. While CTX-M variants are well-characterized in clinical settings, thei...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...

Computational modeling of protein-protein interactions (PPIs) is a high priority because it is essential for understanding nearly all cellular functions and for addressing the limitations of time-consuming experimental m...

Social determinants of health (SDOH) are the conditions in which people live, work, and play, and the wider set of factors (e.g., social and economic systems and policies) that shape a person's daily life. SDOH can diffe...

Abstract Background Genetic aberrations are among the critical driving factors of lung cancer. Importantly, the impact of genetic variations on proteomic dysregulations with the goal of characterizing potential diagnosti...

This paper presents an innovative parallel computational methodology employing adaptive fractional differential operators to address Monkeypox epidemiological modeling challenges. The complex dynamics of such models ofte...

Abstract Multi-label chest X-ray classification faces three critical challenges: (i) inadequate modeling of inter-pathology dependencies despite clinical co-occurrence patterns, (ii) severe class imbalance (11.2−47.6...