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Patients with chronic kidney disease may show altered pharmacokinetics and pharmacodynamic responses to many drugs in comparison to patients with normal renal function. Therefore, effective and safe drug usage is difficu...

Abstract Introduction Brazil is one of the countries with the highest rates of alcohol-related traffic infractions, but little is known about the profile of the drivers who commit them. Identifying the characteristics ...

Closely linked to the increase in psychotropic pill consumption, forgetting and remembering emerged from devastated social scenarios as a new local idiom among poor youth in the late 1990s and the new millennium. Drawing...

Background Recently, publications have hypothesised that the demonstrated increase in the incidence of schizophrenia in New Zealand is a side effect of the increased strength of available cannabis derivatives over the la...

Rational prescription occurs when patients receive the appropriate drug in adequate dose for the necessary period of time and it represents the safest and cheaper pharmacotherapy. The aim of this study was to identify ...

"Clinical Decision Support Systems can alert health professionals about drug interactions when they prescribe medications. The Hospital Italiano de Buenos Aires in Argentina developed an electronic health record with dru...

The COVID-19 pandemic prompted several drug repositioning initiatives with the aim to rapidly deliver pharmacological candidates able to reduce SARS-CoV-2 dissemination and mortality. A major issue shared by many of the ...

Antibiotic use in outpatient settings accounts for the majority of overall antibiotic consumption, yet inappropriate prescribing and drug-related problems (DRPs) remain prevalent and underreported. Conducting a scoping r...

This article aims to understand how it is for psychoactive users to experience the use of substances in a Drug Consumption Room (DCR) for harm reduction and how it impacts their lives and subjectivities. The work starts ...

Abstract Background The use of antipsychotic drugs has increased in recent years, extending beyond traditional indications like schizophrenia and bipolar disorder while the use of lithium has remained stable or declined....

Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for managing pain, fever, and inflammation. Though over 30 million people use NSAIDs worldwide, a widespread unawareness of their side...

This study aimed to examine the relationship between marijuana use and aggression and victimization among Colombian adolescents. We aimed to clarify marijuana’s distinct role by comparing different categories of drug u...

O crescente consumo de drogas no Brasil atinge uma população cada vez mais jovem, inclusive estudantes. Os levantamentos epidemiológicos realizados entre alunos brasileiros de educação básica concluíram que a gran...

This article reassesses the book Africa and the War on Drugs (2012) and a related special journal issue (2016) in the light of drug market and policy developments since 2012. As part of this reassessment, we question som...

Benjamin Betunga,1 Lilian Nuwabaine,2 Joseph Kawuki3 1Tororo General Hospital, Tororo, Uganda; 2Africa Health Sciences University, Kigali, Rwanda; 3Department of Family, Population & Preventive Medicine, Stony Brook ...

Considerable resources have been spent on estimating the size of populations of people who use drugs (PWUD) and people who inject drugs (PWID) in Africa. Precise estimates are elusive, not least because of stigma and cri...

African countries have been experiencing an upsurge in public health problems as a result of the increased availability and use of psychoactive substances trafficked into the continent and also produced locally. However,...

IntroductionEarly identification of adolescents at risk for substance use is critical for timely intervention. However, standard screening tools like CRAFFT (Car, Relax, Alone, Forget, Family and Friends, Trouble) and S2...

ObjectiveTo analyze the rates of drug resistance of carbapenem-resistant Klebsiella pneumoniae (CRKP) and extended-spectrum β-lactamase-producing Escherichia coli (ESBL-E.coli) in bronchoalveolar lavage fluid (BALF) of ...

AimsTo identify drug-related problems (DRPs) associated with proton pump inhibitors (PPIs) and their influencing factors among hospitalized nephrology patients, thereby providing evidence for the rational use of PPIs.Met...

ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

Abstract Background Managing the simultaneous treatment of HIV/AIDS and tuberculosis (TB) increases the risk of adverse reactions, drug interactions, and challenges to treatment adherence. To address these complexities, ...

Abstract Objective To investigate whether serum lysyl oxidase-like 2 (LOXL2) and chitinase-3-like protein 1 (YKL-40) levels are associated with drug-resistant Mycobacterium tuberculosis in children with pulmonary tubercu...

ObjectivesSince its inception in 2017, China’s National Drug Price Negotiation (NDPN) has served as a crucial mechanism for the strategic procurement of innovative medicines, with pediatric medicines representing a key...