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BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, leading to a spectrum of motor and non-motor symptoms. In addition to the motor deficits...

Abstract Microfluidic platforms have emerged as powerful tools for efficient intracellular delivery of exogenous cargo. While droplet microfluidics coupled with cell mechanoporation shows significant potential, its broad...

Background: Women with previous caesarean deliveries (CD) contribute to rising CD rates globally, yet limited evidence exists from rural South African district hospitals. The social value of this study lay in understand...

Abstract Background Community Health Workers (CHWs) have been widely used in response to the shortage of skilled health workers especially in resource limited areas. China has a long history of involving CHWs in public h...

The rising concern of antimicrobial resistance, coupled with the continually challenging management of complicated diseases such as cancer, has provided momentum toward precision molecular medicine. This review provides ...

Abstract Ocular neovascular and neurodegenerative diseases, such as diabetic retinopathy and age-related macular degeneration, are characterized by abnormal angiogenesis, vascular leakage, and progressive retinal neurode...

Polyphenol Oxidases (PPOs) catalyze the conversion of phenolic substrates to quinones, leading to the formation of dark-colored precipitates in fruits and vegetables. This process, known as enzymatic browning, is the cau...

Gene therapy holds a great potential for treating a variety of human disorders by introducing foreign therapeutic genetic material into target cells using gene carriers (vectors). Most particularly, viral vectors show a ...

The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...

ABSTRACT Selective recognition of cancer‐associated proteins (CAPs) by antibodies, followed by their delivery into the intracellular organelle, the lysosome, results in targeted degradation of CAPs and suppresses the g...

Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film-based drug delivery devices is described...

Abstract Bone defects present significant challenges in clinical practice due to the limitations of traditional treatments. Compared to traditional cell therapies, exosome-based therapies have emerged as a promising alte...

Subretinal delivery of retinal pigment epithelium (RPE) cells is an important treatment for retinal degeneration patients, and the cell suspension method is the most common approach. Injectable hydrogel-mediated cell eng...

Abstract Background Excessive mechanical stress is a major cause of intervertebral disc degeneration (IVDD). Macrophages can sense physical signals, but their role in responding to mechanical stress within the disc to ma...

Xiaoyi Fu,1 Zijian Zhang,1 Qinyi Dong,1 Siying Li,2 Xinman Wang,2 Han Zhang,2 Jiahao Bai,2 Huiyan Han,2 Lei Shi,2 Kaili Zheng,2 Lili Liang2,3 1The Third Clinical College, Shanxi University of Chinese Medicine, Taiyuan, S...

ABSTRACT Background and Aim Health management, leadership, and governance (HMLG) are considered essential for achieving universal health coverage (UHC), and various efforts have been made to strengthen the management, le...

Background: In South Africa, the term ‘service delivery’ has become ubiquitous in public discourse, encompassing a wide array of issues from water outages to damaged roads. However, this generalisation often masks t...

Abstract Background Access to surgical care in Low- and Middle-Income Countries (LMICs) such as Tanzania is extremely limited. Northern Tanzania is served by a single tertiary referral hospital, Kilimanjaro Christian Med...

Reporter genes are employed to improve visualization of specific tissues by creating a higher contrast in MR imaging. The genes on the magnetosome gene island (MAI) in magnetotactic bacteria have been of interest as cont...

Abstract Background South Africa is home to a rich tapestry of cultural and linguistic diversity, with 11 official spoken languages and South African Sign Language recognised as the twelfth. While this plurality reflects...

RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascula...

Objective: Maternal hypotension is a common complication of spinal anesthesia for cesarean delivery, pose a risk to both mother and fetus. Prophylactic and therapeutic strategies must ensure hemodynamic stability. This p...

ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically inter...