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In the growing diversity of human induced pluripotent stem cell (iPSC)-derived models of brain development, we present here a novel method that exhibits 3D cortical layer formation in a reproducible topography of minimal...

A common feature in biological neuromuscular systems is the redundancy in joint actuation. Understanding how these redundancies are resolved in typical joint movements has been a long-standing problem in biomechanics, ne...

ABSTRACT Microbiology, the study of microorganisms, is of critical importance to a variety of fields, including medicine, nursing, genetics, and immunology, as well as to students training to enter those fields. By defin...

Since most physiology core concepts are equally applicable to humans and other multicellular organisms, human physiology instructors may reasonably wonder whether consistent use of nonhuman assessment questions would enh...

Abstract While both common and rare variants contribute to the genetic etiology of complex traits, whether their impacts manifest through the same effector genes and molecular mechanisms is not well understood. Here, we ...

El objetivo de esta reflexión es resaltar la importancia de la influencia del inmunometabolismo macrofágico y su respuesta dirigida a la sepsis humana como un enfoque terapéutico en el futuro cercano. La sepsis es un ...

T follicular helper (Tfh) cells have been reported to have multiple trajectories, including terminally differentiated Tfh, memory-like circulatory Tfh (cTfh), and, most recently, induced T follicular regulatory (iTfr) ce...

Human health is threatened by exposure to reactive toxins that can damage fundamental biomolecules such as DNA and proteins. One of these molecules is formaldehyde, the simplest and one of the most reactive aldehydes. Fo...

The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of infected erythrocytes to the host endothelium and is encoded by approximately 60 var genes pe...

This study aims to examine the role of exosomes derived from human urine-derived stem cells (hUSCs-Exo) in the in vitro construction of a composite structure comprising hUSCs and a porcine urethral decellularized matrix...

Abstract Neural populations that are able to extract quantitative information from multiple sensory domains are essential for the survival of numerous species. How quantity is encoded across different senses is far from ...

Abstract Studies of biological timekeeping have now matured from investigations of a fascinating and ubiquitous phenomenon into a discipline with practical applications; the excitement surrounding such translation has be...

Abstract Background & aims Understanding of the dynamic changes of hepatocytes, hepatic stellate cells (HSC), Kupffer cells (KC), and liver sinusoidal endothelial cells (LSEC) is critical for studying liver (patho)physio...

Temporal analysis of two inducible human genes reveals that H3K4me3 is uncoupled from transcriptional initiation, acting as a post-transcriptional mark rather than a driver of induction. Histone H3 lysine 4 trimethylatio...

Abstract Background Chromatin condensation, accompanied by pronounced nuclear shrinkage, is a pivotal step in terminal erythroid differentiation and is essential for enucleation. However, the precise timing and molecular...

Effective management of natural populations depends heavily on the capacity for understanding and predicting their habitat requirements. For endemic and threatened species like the mara (Dolichotis patagonum), this infor...

Subretinal delivery of retinal pigment epithelium (RPE) cells is an important treatment for retinal degeneration patients, and the cell suspension method is the most common approach. Injectable hydrogel-mediated cell eng...

Hunting and gathering remained the main mode of subsistence of humanity for hundreds of thousands of years, beginning some 1.8 million years ago, and until the Neolithic Revolution (some 10,000 years ago), when agricultu...

We reveal a coordinating role for Cx32-mediated cell–cell communication in maintaining mitotic-quiescence and limiting migration-associated TGFβ signalling, extracellular matrix remodelling and mesenchymal-like change...

In recent years， quantitative microbial risk assessment （QMRA） for food safety has developed rapidly both domestically and internationally. QMRA integrates multidisciplinary theoretical knowledge and technical meth...

Regulatory science governing monoclonal antibody development has undergone a profound transformation over the past decade, shifting from empiricism-driven paradigms toward evidence-efficient, mechanism-based frameworks g...

The p53 transcription factor plays a key role both in cancer and in the cell-intrinsic response to infections. The ORFEOME project hypothesized that novel p53-virus interactions reside in hitherto uncharacterized, unknow...

Background and objectives: Tumors are complex systems characterized by variations across genetic, transcriptomic, phenotypic, and microenvironmental levels. This study introduced a novel framework for quantifying cancer ...

In this study, the authors show that treatment with acetyl-carnitine can ameliorate learning and memory defects and hyperactivity in a mouse model of the cognitive disorder, Arboleda–Tham syndrome. Pathogenic variants ...