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Abstract Inflammatory diseases remain a major clinical challenge due to their complex pathologies and the limitations of current anti-inflammatory therapies. Conventional treatments, such as non-steroidal anti-inflammato...

Abstract Black rhinoceros are critically endangered due to poaching in the wild (in situ). Globally, fewer than 200 animals are maintained as an ex situ insurance population. Unfortunately, the ex situ population faces m...

Abstract Background Periodontal disease exhibits bidirectional associations with autoimmune diseases; however, comprehensive histological, radiographic, and correlational differences in periodontal tissues between patien...

The association between cheese consumption and chronic inflammatory skin conditions remains unclear. We used a two-sample bidirectional Mendelian randomization (MR) framework to investigate the genetic causality between ...

Neurodegenerative diseases (NDs) constitute a growing global health burden driven by population aging and remain without disease-modifying therapies. Although chronic neuroinflammation and aberrant protein aggregation ar...

Abstract This study was performed to evaluate the antioxidant activity of yogurt fermented at low temperature and the anti-inflammatory effect it has on induced colitis with 2.5% dextran sodium sulfate (DSS) in Balb/c mi...

Inflammation-related diseases, including cardiovascular diseases, immune disorders, and infectious diseases, have high prevalence and disability rates, imposing heavy socioeconomic and healthcare burdens. Thus, elucidati...

Severe gingival inflammation, which is uncommon in pediatric patients, often indicates underlying systemic conditions. Leukemia, autoimmune diseases, and allergic symptoms can cause gingivitis owing to systemic inflammat...

Pelvic inflammatory disease (PID) is a complex multifactorial infectious disorder of the female reproductive tract, associated with severe long-term sequelae including infertility, ectopic pregnancy, and chronic pelvic p...

ABSTRACT Cystic fibrosis (CF) and inflammatory bowel disease (IBD) represent distinct pathologies with unique genetic underpinnings; yet, they share remarkable similarities in gut microbiota dysbiosis and intestinal phys...

Interleukin-10 (IL-10) is the most important anti-inflammatory cytokine at intestinal level, and its absence is involved in inflammatory bowel diseases. However, oral treatment with IL-10 is difficult because of its low ...

Psoriasis is a chronic inflammatory skin disease associated with increased proliferation of the epidermis. Combination of genetic, immunological and environmental factors underlies the skin lesion. Until recently, psoria...

Result exciting to deepen the knowledge on vitamin D (VD) nanoformulations applied to the prevention and treatment of specific inflammatory/oxidative diseases such as neurodegenerative and cardiovascular pathologies inst...

Growing evidence has directly linked the gastrointestinal tract, gut microbiota, and central nervous system, forming the gut-brain axis, a process that has been described as a key mechanism in regulating neurological pro...

Globally, one major cause of morbidity and mortality is cardiovascular diseases (CVDs). The burden of cardiovascular disease among the elderly is still high and typically tends to move to nations with lower sociodemograp...

Abstract Objective To investigate the associations between thrombus Matrix Metalloproteinase-9 (MMP-9) level and the systemic inflammatory characteristics in patients with Acute Ischemic Stroke (AIS), and to evaluate the...

Abstract Background Multiple inflammatory markers are central determinants of insulin resistance and cardiovascular inflammation, closely associated with cardiometabolic multimorbidity (CMM). However, the evidence regard...

Abstract Objective Current diagnostic paradigms for Crohn’s disease (CD) activity assessment remain fragmented across imaging and laboratory modalities. This study seeks to investigate the diagnostic efficacy of intest...

ObjectiveExcessive secretion of inflammatory biomarkers exerts adverse effects on muscle strength and function, and is associated with the development and progression of sarcopenia and frailty. For the improvement of inf...

BackgroundNumerous studies indicated inflammatory bowel disease (IBD) patients suffered from sleep disturbances. Although melatonin (MT) exerts positive effects on maintaining circadian rhythms and anti-inflammation, its...

Despite major advances in lipid-lowering therapy and stent technology, a substantial proportion of patients undergoing contemporary percutaneous coronary intervention (PCI) experience recurrent major adverse cardiovascul...

IntroductionMacrophages play a key role in inflammatory diseases. We aimed to identify long noncoding RNAs that regulate pro-inflammatory activation of human macrophages. MethodsWe performed human lncRNA microarray analy...

Janus kinase (JAK) inhibitors represent a major advancement in the management of immune-mediated inflammatory diseases. A balanced approach that carefully weighs therapeutic benefits against potential risks is essential....

ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloido...