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11 resultados encontrados.

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DNA methylation regulation of CYP450-lipid metabolism by high-altitude hypoxia: linking neuroinflammation to cognitive impairment
Artículo
Acceso abierto Artículo DOAJ
DNA methylation regulation of CYP450-lipid metabolism by high-altitude hypoxia: linking neuroinflammation to cognitive impairment
Qian Wang et al · BMC · 2026 · ISSN 1742-2094
Abstract Under high-altitude hypoxia, neuroinflammation contributes to cognitive impairment, though the underlying mechanisms remain unclear. In this study, we established rat and astrocyte models of hypoxic exposure. We...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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Oral sodium butyrate supplementation acts on intestinal dysbiosis and resolves spinal cord neuroinflammation and nociceptive neuron sensitization
Artículo
Material complementario disponible Artículo DOAJ
Oral sodium butyrate supplementation acts on intestinal dysbiosis and resolves spinal cord neuroinflammation and nociceptive neuron sensitization
Antimo Fusco et al · BMC · 2026 · ISSN 1476-9255
Abstract Background Gut microbiota dysbiosis is a key pathological feature closely linked to metabolic disorders and neuroinflammation. It is typically characterized by reduced levels of beneficial microbial metabolites,...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Bystander activation of microglia by Brucella abortus-infected astrocytes induces neuronal death via IL-6 trans-signaling
Artículo
Acceso abierto Artículo CONICET Digital
Bystander activation of microglia by Brucella abortus-infected astrocytes induces neuronal death via IL-6 trans-signaling
Rodríguez, Julia et al · Frontiers Media · 2024 · ISSN 1664-3224
Inflammation plays a key role in the pathogenesis of neurobrucellosis where glial cell interactions are at the root of this pathological condition. In this study, we present evidence indicating that soluble factors secre...
Idioma eng
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Neuroinflammation: a critical bridge linking peripheral pathology and age-related degeneration in myasthenia gravis
Artículo
Material complementario disponible Artículo DOAJ
Neuroinflammation: a critical bridge linking peripheral pathology and age-related degeneration in myasthenia gravis
Fan-yu Liu et al · Frontiers Media S.A · 2026 · ISSN 2296-858X
Myasthenia gravis (MG) has traditionally been conceptualized as a peripheral autoimmune disorder primarily mediated by autoantibodies targeting the neuromuscular junction. However, this classical paradigm fails to adequa...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Low-intensity treadmill exercise preconditioning alleviates post-ischemic stroke injury in mice by inhibiting ischemia-induced inflammation and apoptosis
Artículo
Acceso abierto Artículo DOAJ
Low-intensity treadmill exercise preconditioning alleviates post-ischemic stroke injury in mice by inhibiting ischemia-induced inflammation and apoptosis
Chen Peishan et al · De Gruyter · 2026 · ISSN 2942-6812
The incidence of ischemic stroke continues to rise globally, however, regular physical activity before stroke onset significantly lowers its occurrence. Here, we evaluated whether low-intensity exercise preconditioning c...
LCC LCC:Medicine; TENDOlNwb3J0cw~~Idioma eng
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Culture supernatants from human-derived commensal bacteria alleviate DNCB-induced atopic dermatitis through modulation of inflammatory and barrier-associated pathways
Artículo
Acceso abierto Artículo DOAJ
Culture supernatants from human-derived commensal bacteria alleviate DNCB-induced atopic dermatitis through modulation of inflammatory and barrier-associated pathways
Jaeeun Sin et al · Frontiers Media S.A · 2026 · ISSN 1664-302X
IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by immune dysregulation, impaired epidermal barrier function, and recurrent episodes of itching and inflammation. Emerging evidence...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization
Artículo
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Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization
Jiacan Xu et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundCerebral ischemic injury includes ischemic stroke in adults and hypoxic-ischemic encephalopathy (HIE) in newborns. Delphinidin-3-O-glucoside (Dp3G) is a bioactive anthocyanin abundant in vibrantly colored plant...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies
Artículo
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Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies
Yesim Kaya et al · Frontiers Media S.A · 2026 · ISSN 1662-5161
Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...
LCC LCC:Neurosciences. Biological psychiatry. NeuropsychiatryIdioma eng
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Endoplasmic reticulum stress inhibitor 4-PBA alleviates immune damage in mice with enteroviral encephalitis by inhibiting ferroptosis
Artículo
Acceso abierto Artículo DOAJ
Endoplasmic reticulum stress inhibitor 4-PBA alleviates immune damage in mice with enteroviral encephalitis by inhibiting ferroptosis
Sijie He et al · BMC · 2026 · ISSN 1743-422X
Abstract Introduction Enterovirus A71 (EV71)–associated encephalitis lacks targeted neuroprotective therapy. Experimental data implicate endoplasmic reticulum (ER) stress and ferroptosis in neuronal injury. We tested w...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Increased type 3 deiodinase reduces hippocampal T3 signaling and is associated with cognitive impairment in a sporadic Alzheimer’s disease animal model
Artículo
Acceso abierto Artículo DOAJ
Increased type 3 deiodinase reduces hippocampal T3 signaling and is associated with cognitive impairment in a sporadic Alzheimer’s disease animal model
Rafael Aguiar Marschner et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β and tau pathology, neuroinflammation, oxidative stress, and cognitive decline. Emerging evidence indicates that ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity
Artículo
Acceso abierto Artículo CONICET Digital
Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity
Vinuesa, María Angeles et al · Elsevier · 2016 · ISSN 0306-4530
The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases - with growing impact in modern societies - constitute major ris...
Idioma eng
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