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Currently, the parking management implemented in several public places has not been managed properly, resulting in a buildup of vehicles and it is difficult for many vehicles to find a parking space. The Maspul Jaya boar...

BackgroundFrailty is significantly more prevalent in individuals with Parkinson’s disease (PD) than in general population, yet the underlying neuropathophysiological mechanisms remain poorly understood. This study aime...

Quality of life (Qol) results from a complex interplay of physical, mental, and social aspects. Traditional assessments of Qol may not adequately describe well-being in serious chronic illness such as in people with Park...

Abstract The field of regenerative medicine for Parkinson’s disease (PD) has reached a pivotal moment. After decades of preclinical research, recent first-in-human clinical trials demonstrated that cell replacement the...

Abstract Parkinson’s Disease (PD) is a progressive neurodegenerative disorder that causes motor and cognitive impairments, affecting approximately 1% of individuals over 60 years of age. Speech impairments are among th...

Abstract Ensuring equitable park access amid rapid urbanization and population ageing is essential. We propose an integrated framework that couples street-network impedance modelling with streetscape visual perception to...

Context and background  This study assessed the role of non-timber forest products (NTFPs) in supporting the livelihoods of communities around the proposed Ebo National Park in Cameroon and their contribution to biodi...

BackgroundThe Naples prognostic score (NPS), derived from routine inflammatory and nutritional biomarkers, reflects systemic immune–metabolic status. Its prospective association with Parkinson disease (PD) risk has not...

BackgroundMutations in the PLA2G6 gene cause a spectrum of neurodegenerative disorders, with autosomal recessive early-onset Parkinson’s disease (AREP) and dystonia-parkinsonism (DP) representing the two primary subtyp...

BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder whose advanced stages (Hoehn & Yahr IV–V) place significant demands on informal caregivers, leading to multidimensional burden. Altho...

BackgroundDiscrepancies in symptom concerns and the perceived burden among individuals with Parkinson's disease (PD), their caregivers, and their physicians can hinder effective care.ObjectivesWe investigated differences...

Background: Mutations in the glucocerebrosidase (GBA) gene represent the most common genetic risk factor for Parkinson's Disease (PD) and are associated with a more aggressive motor phenotype at late stages. However, the...

Parkinson’s disease (PD) is a neurodegenerative disorder with increasing prevalence into older age. Aerobic exercise (AE) is the most commonly prescribed exercise for PD, although an optimal protocol is undefined. This...

ObjectiveTo systematically investigate and evaluate the effects of different exercise (TT: treadmill training; ST: sensorimotor training; NW: Nordic walking; CT: cycling training; WT: walking training; DT: dance training...

Introducción: la enfermedad de Parkinson demanda intervenciones integrales que trasciendan el enfoque clínico tradicional y favorezcan la rehabilitación funcional, emocional y social en escenarios comunitarios. En est...

BackgroundPeople with Parkinson’s Disease (PD) treated with dopamine agonists are at increased risk for developing impaired impulse control behavior. It has been suggested that patients tend to underreport problems wit...

Parkinson’s disease (PD) is characterized by profound metabolic disturbances in the brain, yet how these alterations vary across brain regions and respond to neuroprotective intervention remains poorly understood. Here...

Abstract Greece is experiencing one of the most rapid rates of population aging in Europe, leading to a growing burden of Parkinson’s disease (PD), a condition closely linked to advancing age. In this study, we estimat...

Embodied cognition research on Parkinson's disease (PD) points to disruptions of frontostriatal language functions as sensitive targets for clinical assessment. However, no existing approach has been tested for crossling...

Abstract Green infrastructure‐based heat mitigation strategies can help alleviate the overheating burden on urban residents. While the cooling effect of parks has been explored in individual satellite‐based studies, ...

Objectives: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to e...

Objective: To investigate the role of PINK1/Parkin-mediated mitophagy in regulating synaptic remodeling of neuronal cells in depression-like behaviors induced by nonylphenol (NP). Methods: In vitro experiments: HT-22 neu...

Understanding LULC dynamics is essential for biodiversity conservation. This study quantified historical LULC changes from 1987 to 2023 and projected future trends (2023-2059) in Borana National Park (BNP) in southern Et...

IntroductionParkinson’s disease (PD) is the second most common neurodegenerative disorder. The risk of frailty is significantly higher in patients with PD than in age-matched individuals without PD. This study aimed to...