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The Drosophila I-Smad Dad uses MH1-mediated transcriptional regulation in wing tissue but both MH1- and MH2-mediated mechanisms in neurons. Inhibitory Smads (I-Smads) regulate TGF-β/BMP signaling through multiple distin...

Abstract Background Optimization of biotechnological processes is traditionally limited by time-consuming trial-and-error approaches and the complexity of simultaneously optimizing multiple, often conflicting objectives....

IntroductionIndividuals with obesity may be at a higher risk of developing severe periodontitis. We previously reported that C-C motif ligand 19 (CCL19) plays a pivotal role in adipose inflammation in obesity and that ad...

ABSTRACT Spinal cord injury (SCI), which is a severe complication of spinal fractures, often causes the dysfunction of the spinal cord and results in sensory and motor abnormalities. Current clinical treatments—includi...

Background: BPC-157 and GHK-Cu are synthetic peptides with potential in tissue repair, influencing molecular mechanisms in healing, angiogenesis and inflammation. Objective: This review synthesizes preclinical and cli...

The increasing prevalence of artificial light sources has rendered blue light (BL) a novel environmental metabolic disruptor. This study aimed to investigate the potential effects of BL exposure on mitochondrial function...

The Developmental Origins of Health and Disease theory describes early life as a critical window for long-term metabolic health. Accumulating evidence has identified the gut microbiota as a key mediator of early-life met...

Introduction and aims: Healing abutment dislodgement is a common clinical complication in dental implantology, yet its impact on peri-implant soft tissue immunity remains unclear. This exploratory pilot study aimed to in...

A growing number of studies are now utilizing human organotypic brain slice cultures (OBSC), enabled by improved long-term culture protocols that support the investigation of human-specific cellular physiology. Human OBS...

Abstract Objective Tissue-resident memory T (TRM) cells play a key role as “immune sentinels” in mucosal immune protection. However, the molecular regulatory mechanisms underlying the formation and long-term resid...

Connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) is a severe pulmonary complication of connective tissue diseases (CTDs) that occurs in approximately 30% of adult patients with pulmonary art...

Abstract The impedance properties of the clamped forefinger soft tissue under dorsal contact conditions have been largely overlooked, posing challenges for risk assessment in human–robot coexistence. This study address...

Category: Ankle, Basic Sciences/Biologics Keywords: Achilles Tendon Rupture, Achilles Tendon, Achilles Tendon Repair Introduction/Purpose: Peroneal tendon disease (PerTD) is a major cause of lateral ankle pain, including...

Type 2 diabetes mellitus (T2D) features chronic low-grade inflammation in white adipose tissue (WAT), where adipocytes and innate immune cells engage in immunometabolic crosstalk. Mitochondrial damage-associated molecula...

IntroductionLipedema, a painful disease that almost exclusively affects women, leads to an excessive accumulation of subcutaneous adipose tissue, primarily in the extremities. Morphologically, it is characterized by hype...

Abstract Effective management decisions rely on accurate insights into species’ population structure, with high-quality genetic material being essential. Stranded cetaceans are an important source of samples, but meeti...

Abstract Cartilage and synovium are essential tissues involved in joint-related diseases and traits, including osteoarthritis (OA), rheumatoid arthritis (RA), and human height. Although genome-wide association studies (G...

BackgroundCongenital athymia (CA) is a rare T cell immune deficiency, fatal without curative treatment with allogeneic processed thymus tissue–agdc (RETHYMIC) implantation (here termed CTTI). The rate and extent of T c...

Background: The purpose of this systematic review was to determine the prevalence of soft tissue injuries in the upper and lower limbs among professional racquet sports players.Methods: A systematic search was conducted ...

Background: Periodontitis combined with orthodontic treatment creates a complex inflammatory and biomechanical microenvironment in gingival tissue, where macrophages play pivotal roles in tissue remodeling and immune reg...

Abstract Background Various designs of dental implants made of zirconium dioxide (zirconia) as an alternative to titanium implants are available as one-piece implant (OPI) or as bone-level or tissue-level two-piece impla...

Abstract Objective This retrospective study aimed to investigate the transvaginal ultrasound (TVUS) characteristics of different pathological types of retained products of conception (RPOC)—chorionic-decidual versus no...

ABSTRACT The loss of a vast area of tissue requires reconstructive surgery. For the reconstruction of pelvic limb (PL) extremities, the saphenous artery axial pattern flap is recommended. In this report, two dogs receive...

Biofabricated scaffolds facilitate bona fide cellular interactions, cell type specification, and the formation of three-dimensional tissue architecture from human pluripotent stem cells (hPSCs). However, xenogenic biomat...