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Abstract Background The tumour microenvironment and systemic inflammatory environment are related to the diagnosis, treatment and prognosis of various tumours. This study aimed to evaluate the clinicopathological signifi...

Aims: Tenosynovial giant cell tumour (TGCT) management is variable across the UK. Our aim was to examine these differences in clinical practice and develop consensus statements regarding the management of TGCTs. Methods:...

The need for early and precise identification of abnormalities has made the detection and classification of brain tumours essential components of medical diagnosis. Because brain tumours are naturally complex and can hav...

Abstract Background Adoptive cell therapy with tumour-infiltrating lymphocytes has been recognised as a safe and effective treatment for patients with advanced melanoma. Whether such a novel intervention is cost-effectiv...

One of the deadliest diseases that can affect children and adults is a brain tumour. A brain tumour is the abnormal growth of cells in the brain or near it. Commonly, there are two types of tumours: malignant (cancerous)...

Abstract Ipsilateral breast tumour recurrence (IBTR) may represent a true local recurrence (LR) from residual malignancy or a new primary (NP) tumour, with important implications for prognosis and treatment. However, no ...

Background and purpose: The use of Magnetic Resonance imaging (MRI) for radiotherapy planning and guidance for locally advanced non-small cell lung cancer (LA NSCLC) is novel. The superior soft tissue definition of MRI c...

Phyllodes tumours are rare fibroepithelial neoplasms of the breast, accounting for

Introduction: The American College of Radiology (ACR) Bone-Reporting and Data System (Bone-RADS) gave a structured framework for assessing and reporting bone tumours. Aim: To evaluate the diagnostic performance of the...

Conjunctival vascular tumours are rare in adults and often pose diagnostic challenges due to overlapping features between haemangioma and lymphangioma. A 22-year-old male presented with painless, slowly enlarging mass in...

Abstract TP53 is frequently mutated in bladder cancer and is associated with aggressive disease, yet actionable strategies that also improve responses to immune checkpoint blockade remain limited. Here we show that APR-2...

Background and Purpose: Deep learning segmentation (DLS) and planning (DLP) models in radiotherapy treatment planning increase consistency and reduce planning time. However, many DL segmentations and plans are manually a...

Objectives: To characterize the proliferative and immunophenotypic profiles of salivary gland mucoepidermoid carcinoma (MEC) and to explore their associations with clinicopathologic features, tumour microenvironment (TME...

Purpose: To compare the results obtained for tumour control probability (TCP) in protracted treatments, we used two models which apply Poisson statistics for clonogenic cell distribution and a non-Poissonian model, empha...

Abstract Background Phantom tumour, also known as a vanishing tumour or fissural pseudotumor, is an uncommon condition that represents a localized, transudative, loculated interlobar pleural effusion. It occurs predomina...

Background: Myeloid sarcoma (MS) is a solid malignant tumour associated with infiltration of immature myeloid precursor cells in an extramedullary site. The term MS has replaced the term granulocytic sarcoma and chloroma...

Aims: Patient-specific Ti-6Al-4V lattice implants present a new era for reconstruction of weightbearing segmental defects; however, robust clinical data from larger cohorts with longer follow-up remain limited. Building ...

Introduction. Basal cell carcinoma is the most common tumour of the eyelids and periocular region throughout the world. BCC represents 90 % of malignant tumours of the eyelids, predominantly in the male population. The i...

Erythropoietin (EPO) defi ciency is the main cause of renal anemia. However, chronic infl ammation may be one of the important causes for EPO resistance in patients with renal anemia. Inhibition of erythropoiesis by cyto...

Abstract Background Thoracic surgery involves complex diseases and critically ill patients, demanding doctors to integrate solid theoretical knowledge with practical skills. Clinical medical students, however, often stru...

We report a rare case of left atrial myxoma in a 70-year-old female presenting with exertional dyspnoea and palpitations. Echocardiography demonstrated a pedunculated mass attached to the interatrial septum. Surgical exc...

Peripheral giant cell granuloma is the most common jaw located giant cell lesion. It originates from periosteum or from periodontal membrane as a response to local irritation or chronic trauma. It appears as a firm, soft...

Background: Cuproptosis, a copper-dependent form of programmed cell death, has been implicated in the progression of various cancers. However, the role of LOXL2 - a cuproptosis-related gene (CRG) - and its prognostic val...

ABSTRACT: Introduction and aims: To provide the research progress on the cGAS-STING signalling pathway and its related roles in various oral diseases. Methods: We reviewed the recent research on cGAS-STING in PubMed. Th...