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"Herein, we describe the syntheses of 3,5-disubstituted imidazo[2,1-b]thiazole. The cyclization step was performed in two different conditions by using either thermal or microwave heating. Comparing the results of both m...

4-Nerolidylcatechol (4-NRC) is the most abundant antioxidant product isolated from the roots of Pothomorphe umbellata (L) Miq. It displays important sunscreen protection and other pharmacological properties comprising an...

Fifteen 2-[(substituted-benzylidene)-amino]-5-methyl-thiophene-3-carbonitrile (3a-g) and 2-[(substituted-benzylidene)-amino]-4,5-cycloalkyl-thiophene-3-carbonitrile derivatives (4a-h) were synthesized and screened for th...

Fungi play a predominant role in microbial infections with serious health risk to immunocompromised individuals, including AIDS, cancer, diabetics, newborns and elderly patients. Fungi specific riboflavin metabolism invo...

4-methyl-3-(6-{[arylmethylene] amino} pyridin-3-yl)-2H-chromen-2-one derivatives containing different functional groups have been synthesized and screened for their antibacterial activity against four different strains o...

In this study, calcium antagonistic activity of sixteen hexahydroquinoline derivatives have been elucidated in rat ileum and rat thorasic aorta. In the studies on isolated rat ileum, it has been observed that all compo...

In this article we consider the problem of computing approximations to the second derivatives of functions of n variables using finite differences. We show how to derive different formulas and how to comput the errors of...

In this work the antibacterial activity of two pregnenolone-derivatives was evaluated on V. cholerae and E. coli, using a NCCLS broth dilution modified method. Additionally, to delineate the structural chemical requireme...

A new series of silver (I) 4-substitutedbenzenesulfonate derivatives (1-8) have been synthesized in order to search for new potential antibacterial agents. The antibacterial activity of 1-8 against various strains of b...

Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, affects 9-12 million of people in Latin America and it is an important cause of heart disease. Although transmission has been reduced, an effective the...

In the present investigation, extended release tablets of metoprolol succinate were developed using cellulose derivatives and natural gums as matrix formers and were evaluated for its extended release characteristics. Th...

The understanding of the prototropic lactam/lactim/enol equilibrium and the E/Z isomerism around the N-C(O) bond in amides is important for the determination of different physicochemical properties in compounds, moreover...

Ten new 4-thiazolidinone derivatives have been synthesized from the alkanoic acids. Alkanoic acid hydrazides (I) on refluxing with aromatic aldehydes in the presence of a catalytic amount of glacial acetic acid in methan...

Six new dodecanoic acid hydrazide-hydrazones (compounds 4a–f), unsubstituted or carrying hydroxy, methoxy, nitro and chloro groups on the benzene ring, were synthesized and tested, in vitro, for their antimicrobial act...

A novel series of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1, 2, 4-triazole derivatives were synthesized by reaction of 5-substituted phenyl-3,4-diamino-1,2,4-triazole with different aromatic aldehydes. T...

A novel series of 2-hydrazolyl-3-phenyl-5-(4-nitrobenzylidene)-4-thiazolidinone substituted (3a-p) has been synthesized. The intermediates 2-hydrazolyl-3-phenyl-4-thiazolidinone substituted (2a-p) were prepared by conden...

Clusia minor fruits were investigated and three polyprenylated benzophenones were isolated using several chromatographic techniques. All the structures assigned (propolone D, hyperibone B and garcinielliptone I), inclu...

In the search for new compounds for the treatment of Chagas disease, the cysteine protease cruzipain remains as one of the most attractive biomolecular targets for drug development. Thiosemicarbazones (TSCs) have been id...

"This work described the preparation and characterization of water insoluble chitosan derivatives as lead adsorbents. In highly regioselective reactions, N-substituted crosslinked chitosan derivatives were obtained by cr...

Cylin dependent kinases (CDKs) have emerged as novel mechanistic target due to their direct involvement in underlying genetic changes during the cancerous state. In order to identify the essential physiochemical paramete...

Las características conformacionales y electrónicas del acido valproico (vpa), valpramida (vpd), valproato de etilo (evp), valproato de propilo (pvp), valproato de butilo (bvp), valproato de isobutilo (ibvp) y valproat...

In the present study matrix and multilayered matrix tablets of diltiazem HCl were formulated by using guar gum as matrix core component and cellulose derivative, Sodium Carboxy Methyl Cellulose (SCMC) as barrier layers. ...

Insulin resistance is associated with a defect in protein tyrosine phosphorylation in the insulin signal transduction cascade. PTPase enzyme dephosphorylates the active form of insulin receptor and thus attenuates its ty...

A simple HPLC method was developed to study the pharmacokinetics of tobramycin in rat after intravenous administration. The plasma samples were deproteinized with acetonitrile after addition of the internal standard, net...