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36 resultados encontrados.

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Development and evaluation of modified locust bean microparticles for controlled drug delivery
Artículo
Material complementario disponible Artículo SEDICI UNLP
Development and evaluation of modified locust bean microparticles for controlled drug delivery
Gowda, D. Vishakant et al · SEDICI UNLP · 2011
The objective of the present study was to minimize the unwanted toxic effects of antihypertensive drug diltiazem hydrochloride (DTZ) by kinetic control of drug release from microparticles using chemically modified locust...
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DrugBank 5.0: a major update to the DrugBank database for 2018
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DrugBank 5.0: a major update to the DrugBank database for 2018
David S. Wishart; Yannick Djoumbou-Feunang; An Chi Guo; Elvis Lo; Ana Marcu; Jason R. Grant; Tanvir Sajed; Daniel L. Johnson · Nucleic Acids Research · 2017
DrugBank (www.drugbank.ca) is a web-enabled database containing comprehensive molecular information about drugs, their mechanisms, their interactions and their targets. First described in 2006, DrugBank has continued to ...
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Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract
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Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract
Dalvadi, Hitesh P. et al · SEDICI UNLP · 2011
The present investigation concerns the development of mucoadhesive tablets of captopril which were designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated u...
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Development, evaluation and optimization of baclofen oral floating tablet
Artículo
Material complementario disponible Artículo SEDICI UNLP
Development, evaluation and optimization of baclofen oral floating tablet
Singh, Akhilesh V. et al · SEDICI UNLP · 2010
The present investigation concerns the development of a floating matrix tablet, which after oral administration prolong the gastric residence time and increases bioavailability of drugs, which are predominantly absorbed ...
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Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform
Artículo
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Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform
Singh, Akhilesh V. et al · SEDICI UNLP · 2010
The present study evaluated novel polymer mixtures prepared by spray drying of an aqueous dispersion of moth bean starch with Carbopol 934P and HPMC K4M for to be used as platform for peroral mucoadhesive drug delivery...
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Development and evaluation of naproxen sodium 250 Mg effervescent tablets
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Material complementario disponible Artículo SEDICI UNLP
Development and evaluation of naproxen sodium 250 Mg effervescent tablets
Hanif, Muhammad et al · SEDICI UNLP · 2011
Effervescent tablets have always been convenient, simple and measured dosage form. The phenomenon of carbonation, in this type of dosage form, accelerates the solubility and enhances the bioavailability of the drug and t...
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Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former
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Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former
Villanova, Janaina C.O. et al · SEDICI UNLP · 2011
The purpose of this paper was to produce controlled-release matrices with 120 mg of propranolol hydrochloride (PHCl) employing hydroxypropyl methylcellulose (HPMC, Methocel® K100) as the gel forming barrier. Although th...
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Development and validation of a RP-HPLC method for determination of citicoline monosodium in human plasma
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Development and validation of a RP-HPLC method for determination of citicoline monosodium in human plasma
Bindaiya, Shailendra K. et al · SEDICI UNLP · 2011
A sensitive and specific high performance reversed phase liquid chromatographic method was developed for quantification of citicoline monosodium (CTM) in human plasma. The active drug was isocratically eluted at a flow r...
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Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
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Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
Hussain, Talib et al · SEDICI UNLP · 2011
The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide ...
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Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
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Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
Murtaza, Ghulam · SEDICI UNLP · 2011
The aim of this study was to develop sustained release formulation for improving bioavailability of metronidazole designing metronidazole loaded chitosan microcapsules (MLCM) using coacervation technique. Two solutions w...
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Development of risk score to hospitalized patients for clinical pharmacy rationalization in a high complexity hospital
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Development of risk score to hospitalized patients for clinical pharmacy rationalization in a high complexity hospital
Zuckermann, Joice et al · SEDICI UNLP · 2011
The aim of the present research was to build a tool to classify patients according to drug theraphy risk so as to rationalize the use of clinical pharmaceutical resources in hospital settings. Risk factors selected in th...
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In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system
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In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system
Alcântara, Mara T. S. et al · SEDICI UNLP · 2011
Papain has been known by many decades for wounded tissues repair. However, papain stability is not high enough to be commercialized in a stable pharmaceutical form; therefore its use is limited. The strategy to entrap pa...
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Christopher A. Lipinski; Franco Lombardo; Beryl W. Dominy; Paul J. Feeney · Advanced Drug Delivery Reviews · 1997
Materias / palabras clave: Solubility; Drug discovery; Chemistry; Thermodynamics; Permeability (electromagnetism); Hildebrand solubility parameter; Permeation; Work (physics); Computational chemistry; Organic chemistry; Physics; Membrane
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Christopher A. Lipinski; Franco Lombardo; Beryl W. Dominy; Paul J. Feeney · Advanced Drug Delivery Reviews · 2001
Materias / palabras clave: Solubility; Drug discovery; Thermodynamics; Chemistry; Permeability (electromagnetism); Computational chemistry; Physics; Organic chemistry; Membrane; Biochemistry
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Design and development of gastro retentive drug delivery System of tramadol hydrochloride
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Design and development of gastro retentive drug delivery System of tramadol hydrochloride
Rathore, Devashish et al · SEDICI UNLP · 2011
The present investigation concerns the development of floating tablets of tramadol hydrochloride, which after oral administration are designed to prolong the gastric residence time; improves the drug bioavailability, red...
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Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
Artículo
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Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
Ige, Pradum P. et al · SEDICI UNLP · 2011
The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet...
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SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
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SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
Antoine Daina; Olivier Michielin; Vincent Zoete · Scientific Reports · 2017
To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur. Drug development invol...
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Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films
Artículo
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Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films
Pattnaik, Satyanarayan et al · SEDICI UNLP · 2009
In the present study, the influence of polymeric concentration, its blend and drug loading dose on the in vitro drug release pattern of alfuzosin hydrochloride from its transdermal patches has been investigated. Ratio ...
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Alternative technologies to improve solubility of poorly water soluble drugs
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Alternative technologies to improve solubility of poorly water soluble drugs
Lima, Ádley A. N. et al · SEDICI UNLP · 2008
The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Solid dispersions (SD) and inclusion complexes (IC) are two of the most promising strategies to improve the oral...
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Design, development and evaluation of immediate release gliclazide tablets
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Design, development and evaluation of immediate release gliclazide tablets
Mahjabeen, Sanjida et al · SEDICI UNLP · 2011
The aim of the current study was the design, development and optimization of oral immediate release solid dosage forms of gliclazide tablets, intended for rapid action within 30 min, formulated and optimized by in vitro ...
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Dissolution Improvement of Poorly Water Soluble Drug Valsartan and Improving Flow Properties of Solid Dispersion
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Dissolution Improvement of Poorly Water Soluble Drug Valsartan and Improving Flow Properties of Solid Dispersion
Kshirsagar, Sanjay J. et al · SEDICI UNLP · 2010
The aim of the present investigation is to improve the dissolution of poorly water soluble drug valsartan by preparing solid dispersions and also to evaluate the effect of different inert carriers on flow properties of s...
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Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
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Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
Wadekar, Sharadchandra B. et al · SEDICI UNLP · 2011
The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence ...
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Incidence of adverse drug reactions at a university hospital in Southern Brazil
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Incidence of adverse drug reactions at a university hospital in Southern Brazil
Gonzalez, Cristina et al · SEDICI UNLP · 2011
We aimed to evaluate the incidence of adverse drug reactions (ADRs) at a hospital, determine the variation in the incidence of ADRs between genders and among age groups, and determine the pharmacological class most often...
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Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
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Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
Bermúdez, José M. et al · SEDICI UNLP · 2010
The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the loc...
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