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S-adenosylhomocysteine (SAH) hydrolase deficiency is a rare autosomal recessive disorder caused by pathogenic variants of the gene AHCY. Loss of SAH hydrolase causes SAH accumulation and impairs the methionine/S-adenosyl...

Abstract Epithelial-to-mesenchymal transition (EMT) is a complex and dynamic cellular process during which epithelial cells lose their polarity and cell adhesion capabilities and subsequently express mesenchymal stem cel...

Abstract The present work reviews the epidemiologic situation of Anaplasma marginale and Babesia spp. infections and the occurrence of cattle tick fever outbreaks in Brazil. In areas of tick fever enzootic instability, e...

Lassa fever is a zoonotic disease endemic to several West African countries, with seasonal outbreaks and potential to cause future epidemics. Vaccines and other medical countermeasures are in development, requiring relia...

IntroductionRNU4ATAC-opathies are characterized by biallelic pathogenic variants and include three recognized phenotypes: autosomal recessive Roifman syndrome, microcephalic osteodysplastic primordial dwarfism (MOPD), an...

Abstract Rift Valley fever (RVF) is a mosquito-borne zoonosis of major concern for human and animal health, yet no licensed human vaccine exists. Here, we engineered a self-assembling nanoparticle vaccine candidate by ge...

Abstract Fasciolosis is a foodborne anthropozoonotic disease caused by Fasciola spp. that affects multiple hosts worldwide. Genetic characterization studies have revealed considerable diversity within F. hepatica populat...

Scabies mite infection in the developing countries was globally recognized as a neglected tropical disease by the WHO in 2012. The morbidity worldwide persists at a permanent level of 300 million infections per year. Tha...

IntroductionComplement C2 deficiency is a classical pathway defect associated with recurrent infections and autoimmunity. This case demonstrates the need for increased awareness amongst rheumatologists for the indication...

Abstract Current treatment for atherosclerotic cardiovascular diseases (ASCVD) mainly focuses on the modification of systemic risk factors, such as hyperglycemia and hyperlipidemia. Despite significant efforts and expans...

The pandemic of COVID-19 left profound global impacts on public health, economics, and social dynamics. Since its emergence, the virus has spread across 229 countries, infecting over 590 million individuals and causing 7...

The budded phenotype (BV) of the baculovirus AcMNPV has been demonstrated to have strong immunostimulatory properties that are relevant for the development of vaccines and antiviral therapies. Although the occluded pheno...

Abstract Immunisation is one of the most cost‐effective interventions to prevent and control life‐threatening infectious diseases. Nonetheless, rates of routine vaccination of children in low‐ and middle‐income c...