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Abstract Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary malignant tumors with poor prognosis and limited therapeutic options. Recent studies have highlighted the role of the immune system in the deve...

In this paper we investigated whether protein kinase C (PKC) b1 and PKCe, members of the classical and novel PKC family respectively, induce phenotypic alterations that could be associated with tumor progression and meta...

Tumor metastasis is the leading cause of mortality in patients with malignant cancers, and the establishment of the pre-metastatic niche (PMN) is recognized as a pivotal step in this process. With growing insight into th...

Aging is a normal process experienced by humans. One of the causes of aging is the body's intrinsic activity, such as the activity of one of the extracellular matrix-breaking enzymes, collagenase. Demand for skin care to...

Reparation of damaged tissues is an essential biological process that ensures maintenance of homeostasis. Basically it includes phases of inflammation, proliferation and remodeling. The result of healing of damaged tissu...

BackgroundIt is well established that tumor-associated macrophages (TAMs) are crucial to the development of tumors. Here, we looked into how SHP2 and M2/M1 macrophages affected gastric cancer.MethodsBulk RNA-seq analysis...

Background: Periodontitis combined with orthodontic treatment creates a complex inflammatory and biomechanical microenvironment in gingival tissue, where macrophages play pivotal roles in tissue remodeling and immune reg...

Abstract Subarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies signifi...

ABSTRACT Background Intervertebral disc degeneration (IVDD), a prevalent spinal disorder, is closely associated with abnormal mechanical stress. The nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplat...

The demineralization of dental hard tissues can be caused by dental plaque. Dental plaque contains various components, especially bacteria attached to the extracellular matrix. Streptococcus mutans (S. mutans) has extrac...

The functions of the intestinal system are crucial for animal health and productivity, as they ensure digestion, nutrient absorption, immune homeostasis, and microbiota regulation. Molecular markers of the intestinal sys...

The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, su...

Per- and polyfluoroalkyl substances (PFAS) are highly persistent environmental contaminants that pose potential ecological and health risks to humans and wildlife. This study investigated the comparative toxicity of four...

Arterial Tortuosity Syndrome (ATS) is a rare autosomal recessive connective tissue disorder caused by mutations in the SLC2A10 gene encoding the glucose transporter GLUT10. GLUT10 deficiency leads to the accumulation of ...

IntroductionMicrogravity is one type of external stimulus that affects bone homeostasis and bone development. This study investigates the molecular drivers of these effects in order to more fully understand the cellular ...

Abstract Cerebral cavernous malformations (CCMs) are vascular lesions associated with severe neurological complications. Increasing evidence suggests that cancer-like mechanisms, like an abnormal expansion of CCM3 knocko...

Abstract Background Peroxiredogenase 2 (PRDX2) has been confirmed to be downregulated in patients with intervertebral disc degeneration (IDD). However, the role and mechanism of PRDX2 in the progression of IDD are still ...

The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...

Abstract Abdominal aortic aneurysm (AAA) is a common cardiovascular disease resulting in high mortality rate due to rupture. Intraluminal thrombus (ILT) is involved in AAA progression via both biomechanically protective ...

Bacterial biofilm are complex microbial communities covered by a matrix of extracellular polymeric substances, which develops when a community of microorganisms irreversibly adheres to a living or inert surface. This str...

Phytoestrogens (PE) such as genistein (Gen) are considered a natural therapy to counteract the risk of cardiovascular diseases in postmenopausal women. Atherosclerosis is a chronic inflammatory process that, in the later...