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Circadian clocks coordinate time-of-day-specific metabolic and physiological processes to maximize organismal performance and fitness. In addition to light and temperature, which are regarded as strong zeitgebers for cir...

Abstract Background The kinematics of the wrist have been widely studied in terms of flexion/extension, radial/ulnar deviation, and the dart-throwing motion (DTM); however, the opposite dart-throwing motion (oDTM)—desp...

Necroptosis, a regulated form of necrotic cell death governed by the RIPK1-RIPK3-MLKL axis, is critically involved in host defense, inflammatory responses, and the pathogenesis of diverse diseases. Given the expanding co...

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic targets. Hypoxia, autophagy, apoptosis, and translational stress are key biological processes involved in tumor p...

Abstract Psychiatric disorders place considerable burden on individuals and on public health. Funding for research in psychiatry is less than ideal, but even so high quality research is being conducted at many centers. H...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...

Abstract Background Bacterial cancer therapies have regained attention as a strategy to remodel the immunosuppressive tumor microenvironment (TME). Engineered bacteria equipped with tumor-targeting moieties can enhance i...

Abstract AI is reshaping medical research and healthcare delivery, yet the translation of AI innovations into clinically approved medical devices remains limited. This article explores the critical role of regulatory fra...

Andrés Bello was born in Caracas in 1781, lived in London from 1810 to 1829, and then in Chile from 1829 up to his death in 1865. He is perhaps the most influential scholar in Latin America’s 19th century, as it can b...