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HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis. HELIOS shares a conserved N-terminal DNA-binding and C-terminal...

The United States Immunodeficiency Network (USIDNET) is a registry that collects de-identified patient data from hospitals across the country to study rare immune conditions, including inborn errors of immunity (IEI). Th...

The purpose of this study is to examine the effects of applying anodal tDCS (2 mA for 20 min) over the scalp from T3 (anodal-tDCS) to Fp2 (cathodal-tDCS) on the perceptual, physiological and performance responses dur...

Near midair collisions are precursor events to actual collisions and may be an indicator of risk. While previous studies have used reports of near midair collisions to relate factors such as airspace saturation to near m...

SASH3 deficiency is an X-linked combined immunodeficiency characterized by recurrent sinopulmonary, cutaneous, and mucosal infections, refractory autoimmune cytopenia, and immune dysregulation. We report here the first t...

Predictive modeling of natural sediment-laden flows requires rheometric protocols that are both reproducible and time-aware of sediment dynamics. This study establishes a standard measurement protocol for homogeneous sed...

The ongoing biodiversity disappearance on islands worldwide is alarming. Without an accurate biodiversity assessment, it is impossible to stop the loss of the world’s islands irreplaceable natural heritage. To assess b...

Os objetivos do presente estudo foram a caracterização e a determinação das estimativas dos parâmetros relativos à cinética de degradação ruminal dos carboidratos contidos nas amostras dos volumosos feno de alfa...

BackgroundRenal cell carcinoma (RCC) is the most common kidney cancer in adults. The advent of immune checkpoint inhibitors (ICIs), particularly in combination with tyrosine kinase inhibitors (TKIs), has significantly im...

Abstract Objectives Gastroesophageal reflux disease (GERD) is estimated to affect up to one-quarter of the Italian population, generating immense treatment costs. An emergent surgical treatment involving implantation of ...

Abstract Background Progressive retinal atrophy (PRA) was diagnosed in four related male English Cocker Spaniels (ECS) between the ages of 3 and 4 years. All affected dogs were born to clinically unaffected parents that ...

Thymic stromal cells drive T cell development by supplying key cues for progenitor proliferation and differentiation. Although thymic epithelial cells are well characterized, recent studies highlight crucial functions of...

BackgroundTranscription factor forkhead box protein N1 (FOXN1) is the master transcription factor required for differentiation and maintenance of thymic epithelial cells (TECs) and is not only required for embryonic thym...

We study the evolution of dust in a cosmological volume using a hydrodynamical simulation in which the dust production is coupled with the MUPPI (MUlti Phase Particle Integrator) sub-resolution model of star formation an...

Abstract Background Cerebellar ataxia (CA) is a neurodegenerative disorder characterized by progressive impairments in coordination, balance, and gait disturbances. Conventional rehabilitation therapies offer only limite...

Abstract Noncompaction cardiomyopathy (NCCM) and left ventricular noncompaction (LVNC), in their isolated form, are rare cardiomyopathies. They are characterized by a thickened myocardium due to the presence of deep trab...

Abstract This study explores the use of an upper-limb wearable exoskeleton for teaching violin technique to novices through haptic-assisted training. The educational potential of this technology was evaluated using a fra...

IntroductionNeutrophils, the most abundant leukocyte population, play a central role in host defense against group B Streptococcus (GBS), an encapsulated bacterium that frequently causes severe infections in humans, incl...

Abstract Dreams are universal yet highly idiosyncratic experiences. While memories and personal concerns are known to influence dream content, how such influences evolve over time and how stable individual traits shape d...

The RAG1 and RAG2 genes encode proteins essential for initiating V(D)J recombination in T cell receptor and immunoglobulin gene loci. Biallelic pathogenic variants in these genes are implicated in a spectrum of immunodef...

BackgroundProgressive multifocal leukoencephalopathy (PML) is a rare opportunistic brain infection caused by the JC virus, and idiopathic PML is increasingly recognized. Deeper profiling of such patients often reveals oc...

Abstract Background In the neurorehabilitation framework of treadmill-based robot-assisted gait training (t-RAGT), a threefold relationship among physiotherapist (Pht), patient (Pt), and the selected robotic device shoul...

The authors demonstrate how a reduction in energy costs was achieved at the SARAS refinery complex. Fil: Diego Ruiz. Soteica Europe SL; España Fil: Serralunga, Fernán José. Consejo Nacional de Investigaciones Científ...