Buscar recursos académicos

Abstract Background Atlantoaxial (AA) cerebrospinal fluid (CSF) collection in standing horses utilizes the controlled narcotic morphine, thereby limiting feasibility in field practice settings. Objectives To compare AA C...

Abstract Background Despite over a 25% national decline in opioid overdose deaths in 2024, overdose remains a leading cause of mortality in the U.S., with persistent regional disparities. Illinois, for example, reported ...

Background: Spinal metastasis is the most frequent type of spinal tumor. Opioid is the first line of treatment for cancer pain despite a multitude of side effects. This study aimed to evaluate the effectiveness of opioid...

Abstract Background College students are a key population for opioid use, misuse, and subsequent exposure to overdose events. However, their knowledge and attitudes in response to opioid overdose warrant further study. T...

Abstract Objective To examine whether long-term opioid use after total knee arthroplasty (TKA) is associated with subsequent risks of major adverse cardiovascular events (MACE) and all-cause mortality in patients with kn...

Opioids remain central to managing moderate to severe pain, yet they also produce significant and often under-recognized effects on the immune system. In this narrative review, we synthesize evidence from 1994 to 2025 ac...

BackgroundDespite being a minimally invasive procedure, laparoscopic appendectomy (LA) frequently induces substantial postoperative pain in children. While erector spinae plane block (ESPB) has demonstrated efficacy for ...

Abstract Background Parents who experience adverse social risk factors of health (SRFOH) are at risk for child welfare involvement, and those with opioid and/or methamphetamine use (O/MU) and mental health (MH) disorders...

This protocol outlines planned methodology for a systematic review and meta-analysis of dopaminergic neuroimaging findings in individuals with opioid use disorder (OUD). Converging evidence across substance use disorders...

Background Despite limited evidence supporting the long-term effectiveness of opioid therapy and existing recommendations on multi-disciplinary treatment, patients with chronic non-cancer pain (CNCP) continue to receive ...

Abstract NarxCare®, a proprietary opioid risk scoring system embedded in Prescription Drug Monitoring Programs (PDMPs), has generated significant patient complaints. We adhered to the technical specifications and applie...

Background Individual differences have been detected in individuals with opioid use disorders (OUD) in rehabilitation following protracted abstinence. Recent studies suggested that prediction models were effective for in...

Opioid-free Anaesthesia (OFA) for craniotomy is a method employed increasingly for intraoperative and postoperative pain management with reduced opioid side-effects. Standard opioid regimens, although best for analgesia,...

IntroductionThe Ready, Willing, Able framework aids in examining emergency response preparedness among college campuses and student communities. There remains a gap in understanding levels of readiness, willingness, and ...

The misuse of opioids has reached epidemic proportions over the last decade, with over 2.1 million people in the United States suffering from substance use disorders related to prescription opioid pain relievers. This in...

James S Cho,1,2 Julia Zhu,2 Pritesh Topiwala,1,2 David Hao1,2 1Department of Anesthesiology, Mass General Brigham, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USACorrespondence: David Hao, Department of Anesthe...

Introduction. The 2025 FDA approval of suzetrigine (Journavx) ended a 25-year stagnation in analgesic development. This introduced a paradigm shift in pain management. As a first-in-class, highly selective NaV1.8 sodium...

Drugs commonly used in anesthesia practice may significantly alter the oxidative state of blood cells. This mechanism could contribute to the immune suppression that occurs transiently in the early postoperative period. ...

Abstract Background Working dogs exposed to narcotics might require reversal in the field. Objective To explore the pharmacokinetic and pharmacodynamic effects of naloxone administered intramuscularly (IM) or intranasall...

This article highlights the relevance of the humanities to psychiatric discussions. It considers Thomas De Quincey’s autobiographical Confessions of an English Opium-Eater (1821), where the author charts his opium expe...

Mitragyna speciosa (commonly known as kratom) is a tropical tree native to Southeast Asia, ethnobotanically used for pain relief and fatigue management. Kratom has gained popularity in Western countries for its dose-depe...

Background: Post-operative pain still remains a major issue even with modern surgical techniques. Opioids and non-steroidal anti-inflammatory drugs cause many side effects so clinicians try to use opioid-sparing drugs. P...