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Autoimmune cytopenias (AIC) are characterized by immune-mediated destruction of platelets (immune thrombocytopenia [ITP]), red blood cells (autoimmune hemolytic anemia [AIHA]), neutrophils (autoimmune neutropenia [AIN]),...

Abstract Enhanced weathering in agriculture is a potential gigatonne-scale carbon dioxide removal (CDR) pathway, but its potential remains difficult to constrain. We used a formal expert elicitation process to estimate C...

Abstract While housing price prediction is well-studied, the prediction of large-scale housing conditions remains underexplored due to data limitations. This paper addresses this gap by developing a machine-learning mode...

Abstract Erythropoietin (EPO) administration stimulates haematological and non‐haematological adaptations that alter substrate oxidation and enhance aerobic performance. The effects of strenuous exercise and EPO on met...

Spinocerebellar ataxia type 8, a debilitating neurological disease with no effective treatment, is caused by a CAG•CTG expansion mutation. In SCA8 mice, metformin decreases repeat-associated non-AUG proteins and neuroi...

Abstract Mild traumatic brain injury (mTBI) disproportionately affects children and adolescents and has been associated with poorer neurocognitive performance, but the biological mechanisms driving symptom variability an...

Abstract Background The number of calls for ambulances in Australia has been rising faster than population growth, but it is unclear what is driving this demand. This study aims to quantify and compare the drivers of eme...

Abstract Transcriptomics enables comprehensive, multiplexed characterization of cellular states, yet prevailing methods typically require cell fixation or lysis, precluding longitudinal analysis of RNA expression in livi...

Key Points. Physiological normothermic machine perfusion kept kidneys viable for 12 hours with better hemodynamics, urine output, and metabolic stability than clinical normothermic machine perfusion. Physiological normot...

Objective To investigate how patients with sarcoma present prior to diagnosis—through a general practitioner (GP) or another healthcare professional (HCP)—and describe presenting symptoms.Design International observa...

Abstract Background Outdoor play benefits children’s mental wellbeing, social and cognitive development and physical activity levels. However, children’s outdoor play and physical activity have declined in recent yea...

Introduction Early open fracture management aims to minimise the risk of complications. For the most severe open fracture wounds, multiple irrigation and debridement surgeries are required to overcome severe wound contam...

Here, we identify a novel signaling pathway in which Rnd3 regulates the metastatic potential of lung cancer cells. Understanding this pathway could be leveraged to target metastatic disease. Rnd3 regulates cellular proce...

Abstract Background Many individuals with bipolar disorder have decreased levels of cognitive functioning even when in a euthymic mood state. Persons with bipolar disorder are usually treated with psychotropic agents, bu...

Abstract Bird wings exhibit a broad degree of functional and shape variation, though the exact nature of the form-function relationship is uncertain. Recent analysis suggests that functional variability is explained by l...

Abstract Background Borderline personality disorder (BPD) is a significant cause of morbidity with no approved pharmacological treatment. We assessed treatment trajectories of patients with BPD in real-world clinical pra...

Objectives: To describe the experiences of U.S. tuberculosis (TB) program officials participating in contact investigations after TB exposures on aircraft in order to 1) characterize barriers to participation and 2) bett...