Buscar recursos académicos

IntroductionThe integration of tuberculosis (TB) preventive treatment (TPT) into HIV services through electronic health records (EHR) can improve outcomes by enhancing care coordination, reducing redundancies, and suppor...

Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), has killed nearly one billion people in the last two centuries. Nowadays, TB remains a major global health problem, ranking among the thirteen l...

Abstract Objective China has achieved remarkable progress in tuberculosis (TB) control, with the incidence rates declining continuously; however, the disease burden among females remained substantial with pronounced r...

Abstract Tuberculosis (TB) has high morbidity and mortality rates, and drug-resistant strains pose an increasing challenge. Traditional methods for detecting the Mycobacterium tuberculosis complex (MTBC) are insufficient...

Aunque la tuberculosis (TBC) es curable y prevenible, persiste como problema de Salud Pública, a pesar de contar con medidas de diagnóstico y un tratamiento eficaz y de bajo costo. La principal estrategia de control de...

Introduction: Patients with tuberculosis often struggle not only with the burden of physical illness but also significant psychological challenges, especially depression, that affect their quality of life profoundly. Met...

Background: Tuberculosis (TB) is a severe public health issue in prison inmates in Ethiopia since there is no routine screening for TB during prison admission. Also, drug-resistant tuberculosis (DR-TB) is a significant p...

Abstract Objective Tuberculosis (TB) remains a global health threat with an incompletely understood pathogenesis. The RNA epigenetic modification N6-methyladenosine (m6A) is a key regulator of immune responses in various...

Tuberculosis (TB) is one of the most prevalent infectious diseases worldwide. However, few molecules related to bacterial killing within T cell-induced macrophages are known; therefore, elucidating host responses against...

Abstract Background Chronic endometritis (CE) has two principal subtypes—non-specific chronic endometritis (NSCE) and endometrial tuberculosis (ETB). Both can adversely affect embryo implantation. Although ETB is gener...

Background: Latent tuberculosis infection (LTBI) remains a critical reservoir for the global tuberculosis (TB) epidemic, particularly in South Asia, where high population density and socioeconomic disparities amplify its...

Abstract Tuberculosis (TB) remains a major global public health challenge, with drug-resistant tuberculosis (DR-TB) presenting a serious threat to TB management. Conventional treatment faces challenges such as significan...

The study shows that tuberculosis-driven glycolysis in macrophages promotes tunneling nanotube formation, thereby enhancing HIV-1 spread, highlighting metabolism as a target to limit viral dissemination. Tuberculosis (TB...

Abstract Background Tuberculosis (TB) remains a critical global public health issue, particularly in rapidly urbanizing regions where population density and migration facilitate transmission. While whole-genome sequencin...

Background: Tuberculosis (TB) and diabetes mellitus (DM) are major global health concerns that frequently coexist, particularly in low- and middle-income countries. This dual burden negatively affects disease progression...

Abstract Background In Swaziland, as in many high HIV/TB burden settings, there is not information available regarding the household location of TB cases for identifying areas of increased TB incidence, limiting the deve...

Tuberculosis (TB) vaccine design relies on the selection of optimal antigens. However, evidence on candidate antigens is scattered across the literature and rarely linked to critical vaccine parameters, such as immune re...

ObjectiveTo systematically evaluate the incidence of tuberculosis (TB) in cancer patients treated with immune checkpoint inhibitors (ICIs) and compare the risk of TB between ICI-treated and non-ICI-treated cancer patient...

Mixed infection refers to the presence of multiple Mycobacterium tuberculosis strains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes. Mixed inf...

HIV coinfection and multidrug-resistant tuberculosis (MDR-TB) pose a major public health challenge in sub-Saharan Africa, where high HIV prevalence promotes tuberculosis progression and complicates its management. In peo...

IntroductionAsymptomatic individuals with negative Interferon-γ release assay (IGRA) and tuberculin skin test (TST) results are often labeled as tuberculosis-unexposed individuals. We hypothesize that flow cytometric (F...

Mycobacterium tuberculosis (M.tb.) infection leads to over 1.5 million deaths annually, despite widespread vaccination with BCG at birth. Causes for the ongoing tuberculosis endemic are complex and include the failure of...

Tuberculosis is a global public health challenge, disproportionately affecting adolescents in low-and middle-income countries. Malnutrition worsens immune function, delays recovery and increases the risk of treatment fai...

In Argentina, multidrug-resistant tuberculosis (MDR-TB) outbreaks emerged among hospitalized patients with AIDS in the early 1990s and thereafter disseminated to the immunocompetent community. Epidemiological, bacteriolo...