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Ganoderic acids (GAs), the major lanostane-type triterpenoids in Ganoderma lucidum (G. lucidum), possess diverse pharmacological activities but are produced at low levels, limiting their applications. Transcriptional reg...

Abstract Background Ferns, comprising epiphytic, aquatic, and terrestrial varieties, are good models to investigate plant terrestrialization. Vascular tissue represents a significant development in the terrestrial adapta...

Abstract Background Viral infections of tomato plants present a significant threat to tomato production and yield. Mixed viral infections are common in field-grown tomatoes and are known to exacerbate disease symptoms; h...

Ferrochelatases catalyze the insertion of ferrous iron into the porphyrin during the heme b biosynthesis pathway, which is fundamental for both prokaryotes and eukaryotes. Interestingly, in the active site of ferrochelat...

Abstract Background The bark beetle Ips typographus (Coleoptera: Curculionidae: Scolytinae) is a major pest of spruce trees in Central Europe. Its ecological success is mediated by a male-produced aggregation pheromone, ...

IntroductionPancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and invasive malignancies, with limited response to the currently available systemic therapy options. Having a 5-year survival of 12%...

Abstract Background Existing research suggested that the intratumoral microbiome participates in the progression and metastasis of lung cancer. However, its role in distinguishing benign from early-stage malignant pulmon...

ABSTRACT Sulfur (S) is an important nutrient that has wide‐ranging effects on plant health and metabolism. Several classes of transcription factors respond to S deprivation, including R2R3‐MYBs. In Arabidopsis, the A...

Abstract Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy with limited therapeutic options in the relapsed or refractory setting. Selinexor, a selective inhibitor of nuclear export targeting X...

Abstract The activating signal co-integrator 1 complex subunit 3 (ASCC3), a multifunctional protein, has been implicated as a prognostic marker in several types of cancer. However, mechanisms underlying its prognostic va...

Mycotoxins produced by Aspergillus species pose a major threat to food safety, particularly in warm and arid regions where environmental conditions favor fungal persistence and toxin biosynthesis. Aspergillus quadrilinea...

Indonesian women saw premature aging as a serious problem; 60% of female respondents felt less confident due to the symptoms of premature aging they experienced. Fig leaves (Ficus carica L.) are a natural ingredient cont...

Liver cirrhosis is characterized by an excessive accumulation of extracellular matrix components, including hyaluronan (HA). In addition, cirrhosis is considered a pre-neoplastic disease for hepatocellular carcinoma (HCC...

Abstract Heritage crops are recognized for their genetic diversity and naturally elevated antioxidant profiles, including polyphenols, flavonoids, and carotenoids. However, their nutritional value is highly sensitive to ...

ESKAPE, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. pose a significant global health threat due to their extensive ...

Raffinose (Raf) protects plant cells during seed desiccation and under different abiotic stress conditions. The biosynthesis of Raf starts with the production of UDP-galactose by UDP-sugar pyrophosphorylase (USPPase) and...

DNA origami structures based on M13 scaffolds have limitations in terms of functional integration and size expansion. Using longer scaffold strands can substantially increase the number of programmable functional sites a...

Photodynamic inactivation (PDI) combines the use of photosensitizers with visible light to produce reactive oxygen species that effectively eliminate pathogens. To investigate the impact of near- infrared therapy (NIRT) ...

Bordetella bronchiseptica encodes and expresses a flagellar apparatus. In contrast, Bordetella pertussis, the causative agent of whooping cough, has historically been described as a nonmotile and nonflagellated organism....

This study was planned to investigate the possible role of endogenous nitric oxide (NO) in acute hypotension during hemodialysis. Twenty-seven patients who had normal blood pressure before hemodialysis(HD) were included ...

Purple carrots (Daucus carota ssp. sativus var. atrorubens Alef.) accumulate anthocyanins in their roots, petioles and other plant parts. These flavonoid pigments represent an excellent dietary source of antioxidant and ...

Abstract Among various biological agents, bacteriocins are important candidates to control Listeria monocytogenes which is a foodborne pathogen. In this study, a novel bacteriocin, named agilicin C7, was isolated from Li...

Monascus pigments (MPs) are important azaphilone-type polyketide pigments, yet yield control, stability, and safety pose challenges. Using an epigenetic derepression strategy, we constructed an Ash2 deletion mutant in th...

Abstract. Background. Determining the effect of combined metal action on the anaerobic microbial association during the fermentation process and methane production. Objective. To investigate the effect of the simultane...