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This review reexamines the mechanism by which acupuncture (especially electroacupuncture) modulates pain-related affective disorders from an integrative functional framework. We propose that the efficacy of acupuncture s...

Current scientific endeavours in the field of geroscience have begun to reveal how factors such as exercise could modulate the brain aging process. In this review, we ask how exercise could potentially modulate aging, an...

Abstract Background In humans, the T2‐weighted (T2W)—fluid‐attenuated inversion recovery (FLAIR) mismatch sign (T2FMM) is a specific imaging biomarker for the isocitrate dehydrogenase 1 (IDH1)‐mutated, 1p/19q non...

In the growing diversity of human induced pluripotent stem cell (iPSC)-derived models of brain development, we present here a novel method that exhibits 3D cortical layer formation in a reproducible topography of minimal...

The fascia, a pervasive connective tissue network, has traditionally been studied for its structural and biomechanical roles in the human body. However, emerging evidence suggests that fascia may also play a significant ...

Lucie Bartova,1 Mara Lisa Beuster,2 Bruno Bonetti,3 Giuseppe Maina,4,5 Pedro Morgado,6 Johan Nyberg7 1Department of Psychiatry and Psychotherapy, Clinical Division of General Psychiatry, and Comprehensive Center for Clin...

Abstract Growing evidence indicates a crucial role of the gut microbiota in physiological functions. Gut-brain axis imbalance has also been associated with neuropsychiatric and neurodegenerative disorders. Studies have s...

Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...

Abstract Subarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies signifi...

Background and purposeWe observed that some late-term fetal prenatal magnetic resonance imaging (MRI) scans revealed normal brain structures but exhibited diffuse hyperintense signals on T2-weighted imaging (T2WI) in the...

ObjectiveThis study aimed to investigate the effect of high-frequency transcranial magnetic stimulation (TMS) targeting multiple brain regions on the recovery of consciousness in patients with minimally conscious state (...

Abstract Epilepsy is a chronic neurological disease that profoundly impacts patients’ daily lives. Electroencephalography (EEG) serves as a crucial tool for the clinical diagnosis of epilepsy and other brain disorders....

Abstract As consumers become more interested in healthier lifestyles, the global functional food market is expanding. Probiotics have gained attention because of their numerous health benefits to the host and may even tr...

Organotypic slice culture is a sophisticated technique historically used in cellular and developmental neurobiology to investigate three-dimensional architecture and cellular interactions. Maintaining thin tissue slices ...

Gastrointestinal (GI) diseases are common multifactorial disorders involving chronic inflammation, epithelial barrier disruption, immune dysregulation, gut microbiota imbalance, and abnormalities in motility and gut–br...

Abstract Introduction Klippel–Feil syndrome is a rare congenital disorder characterized by the fusion of two or more cervical vertebrae. It may be associated with malformations in other systems, including auditory abno...

The misuse of opioids has reached epidemic proportions over the last decade, with over 2.1 million people in the United States suffering from substance use disorders related to prescription opioid pain relievers. This in...

IntroductionSouth American camelids (SACs) and dromedaries presenting with neurological abnormalities are increasingly common in veterinary practice. Advanced diagnostic imaging techniques, such as computed tomography (C...

Abstract Background SPTBN1 encodes βII-spectrin, a cytoskeletal protein essential for neuronal structure and function. Pathogenic variants in this gene cause a neurodevelopmental disorder known as DDISBA (Developmental ...

Background and Aims: Autism in children is known to affect brain systems implicated in cognitive, communication, social functioning and intelligence. Although autism is a neurobiological disorder, behavioral interventi...

Background. Irritable bowel syndrome is one of the most common chronic gastrointestinal disorders. This disease is diagnosed worldwide, although it is much more common in developed countries. The main role in the develop...

The early stages of life constitute a crucial period for neurodevelopment, during which maternal gut microbiota dysbiosis can impact offspring neurodevelopment via the microbiota–gut–brain axis. This study aimed to e...

Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment. In previous studies we have observed that t...

Exosomes, a specialized class of extracellular vesicles, exhibit significant therapeutic potentials for neurological disorders, in particular for vascular dementia (VaD). VaD is the second most common form of dementia, c...