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IntroductionDelayed cerebral ischemia (DCI) is one of the main causes of disability and death following surgical treatment of ruptured intracranial aneurysms. Many studies combine data from patients undergoing clipping a...

Abstract Axial spondyloarthritis (AxSpA) is a chronic inflammatory condition of the spine and sacroiliac joints, associated with a considerable functional and psychosocial burden. This study aimed to investigate the inte...

S-adenosylhomocysteine (SAH) hydrolase deficiency is a rare autosomal recessive disorder caused by pathogenic variants of the gene AHCY. Loss of SAH hydrolase causes SAH accumulation and impairs the methionine/S-adenosyl...

Background Depression, one of the most frequent complications after stroke, increases the disease’s burden and physical disability. Poststroke depression (PSD) is a multifactorial disease with genetic, environmental an...

Galactosemia involves different forms of inborn errors of metabolism affecting galactose processing. Different from type 1 and type 2, respectively, related to GALT and GALK1 defects, type 3 galactosemia is due to bialle...

ABSTRACT To evaluate the effectiveness of percutaneous endoscopic lumbar discectomy (PELD) in the treatment of recurrent lumbar disc herniation, comparing it with conventional techniques with an emphasis on the improveme...

Introduction:Orthopedic and musculoskeletal pain is a leading cause of disability worldwide, and many patients continue to experience suboptimal relief despite advances in pharmacological and physical therapies. Magnetic...

Abstract Background Ischemic stroke (IS) remains a leading cause of death and disability worldwide. Stroke–heart syndrome, triggered by acute cerebral ischemia, causes autonomic dysfunction that can result in myocardia...

Lissencephaly type 10 (LIS10, OMIM#618873) is a rare neurodevelopmental disorder characterized by posterior-predominant pachygyria/agyria or subcortical band heterotopia on brain imaging. Clinically, affected individuals...

Abstract Background Wilson disease (WD) is a rare inherited copper metabolism disorder with variable prevalence worldwide. Many regions lack reliable data, leading to underestimation of burden. WD presents with hepatic, ...

Despite decades of global attention, work-related musculoskeletal disorders (MSD) remain a significant challenge, with substantial personal and societal costs (1). The lack of progress in addressing this prevalent proble...

Background Major depressive disorder (MDD) is a common psychiatric disease and a leading cause of disability worldwide. Handgrip strength (HGS) as an objective physical fitness test is a practical index for identifying m...

Abstract Background Migraine is a very common chronic neurological disorder associated with severe disability and significant social burden worldwide. Beyond recurrent headache attacks, increasing evidence indicates that...

ABSTRACT Background and Aims Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and neurodegeneration. Conventional MRI techniques lack specificity for ...

Food insecurity is a significant problem in South African rural areas, especially in the Eastern Cape Province, where poverty levels and unemployment are high. This study fills a critical research gap by providing micro-...

Abstract Inclusive education seeks to provide equitable learning opportunities to students with diverse needs. While the “plant kingdom” is a foundational concept in biology, studies show that students—including th...

Objectives There is evidence that treatment expectations predict treatment outcomes in pain management and other clinical conditions. However, translating these insights into clinical practice remains challenging: it is ...

ABSTRACT Background Multiple sclerosis (MS) is the most prevalent immune‐mediated neurodegenerative disease affecting the central nervous system. Ocrelizumab, a humanized anti‐CD20 monoclonal antibody, has demonstrat...

Introduction Despite advances in acute treatment, stroke remains the first cause of acquired disability. Today, there is no effective pharmacological therapy to improve recovery beyond the acute phase. Preclinical studie...

Parents with intellectual or learning disabilities may need support to provide adequate care for their children and prevent problems that can arise in children's welfare or development. Parent training programmes may hel...

Abstract Background Migraine is a prevalent neurological disorder and a leading cause of disability worldwide. Despite effective medications, many patients experience underdiagnosis, suboptimal medication use, and poor a...

Sarcopenia is an age-related progressive disease that increases the risk of falls， disability and death in the elderly， and brings a heavy economic burden to families and society. At present， nutritional supplement...

# Background and Purpose Chronic low back pain (CLBP) is a disabling injury for athletes with an unclear pathway to return to sport (RTS). Biopsychosocial (BPS) treatment can address the complex needs of athletes recov...

Abstract Background Segmental zoster paresis (SZP) of the lower limbs is an uncommon complication of herpes zoster (HZ). Its atypical presentation and variable prognosis make early recognition and comprehensive intervent...