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Longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. In thymic tissue, RANKL tracks medullary—but not cortical—e...

Abstract Background Outbreaks of zoonotic diseases that transmit between animals and humans, against a backdrop of increasing levels of forced migration, present a major challenge to global public health. This review pro...

Abstract Immune system dysregulation is implicated in a wide range of human diseases, including cancer. Genetic studies have shown evidence of a link between immune diseases and cancer; therefore, deficits of immune syst...

Background: Infectious diseases are a global problem, the second human cause of death. Infectious diseases caused by pathogenic bacteria have been treated with a high degree of efficacy. However, even when the 20th centu...

Oral mucosal ageing represents a fundamental reprogramming of the tissue microenvironment, a dynamic process that underlies the functional decline and heightened disease susceptibility observed in the elderly. This revie...

Introduction . Bed bugs belong to the family Cimicidae, which includes two cosmopolitan species: Cimex lectularius and Cimex hemipterus. Bed bugs feed on the blood of humans and animals. As a result of bites, skin change...

Abstract Background Low- and middle-income countries are facing an increasing burden of disability and death due to cardiovascular diseases. Policy makers and healthcare providers alike need resource estimation tools to ...

Background: Outer membrane vesicles (OMVs) from Gram-negative bacteria are spherical lipid bilayer nanostructures with diameters of 20 to 250 nm. Porphyromonas gingivalis (P. gingivalis), a keystone periodontal pathogen,...

Human papillomavirus (HPV) is the most common sexually transmitted infection in the U.S. and the primary cause of multiple anogenital and oropharyngeal cancers. Although HPV vaccination is effective, uptake remains subop...

Abstract Background Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. Methods This review synthesized evidence through a protocol-...

Human papillomavirus (HPV) vaccination is a critical yet underutilized strategy for preventing HPV-related cancers in young adults. University students represent a key demographic for catch-up vaccination owing to their ...

Abstract Cytokines from the transforming growth factor-β (TGF-β) superfamily are essential regulators of cell growth, survival, and differentiation, playing a pivotal role in mammalian embryonic development, adult tiss...

Abstract Background Triggering receptor expressed on myeloid cell-2 (TREM2) signaling promotes disease-associated microglia (DAM) and phagocytosis in neurodegenerative diseases. Traditional anti-TREM2 agonist antibodies ...

Abstract BackgroundHealth and health care systems are progressively challenged by more frequent natural and human-caused hazards. A hazard becomes a disaster when vulnerability and exposure interact in comple...

Background and aimsLiver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune tolerance to ingested antigens. The sca...

Deficiency of adenosine deaminase 2 (DADA2) was identified in 2014 as a novel inborn error of immunity caused by biallelic pathogenic variants in ADA2. DADA2 patients express two predominant clinical phenotypes: (1) auto...

BackgroundEstrogen receptor (ER)-low human epidermal growth factor receptor 2 (HER2)-negative breast cancer shares similar pathological and molecular features with triple-negative breast cancer, yet the utility of the 21...

Abstract This mini review focuses on foodborne illnesses and outbreaks caused by food-producing animals because statistical information of the foodborne illnesses is important in human health and food industry. Contamina...

Abstract The heart-brain axis is a significant contributor to morbidity and mortality following ischemic injury. Pathological and psychological changes in the heart can lead to anxiety, cognitive impairment, and brain in...

Abstract Since the twenty first century, the outbreaks of global infectious diseases have caused several public health emergencies of international concern, imposing an enormous impact on population health, the economy, ...

ABSTRACT: In recent years, the use of computing has increased along with medical skills, and this had impressive results in terms of classification and treatment, in addition to facilitating the matter of medical personn...

Metabolic syndrome (MetS) is a cluster of metabolic disturbances increasing a risk of cardiovascular diseases and diabetes 2 types. The main features of MetS include atherogenic dyslipidemia, elevated blood pressure, ins...

Abstract Background I Kappa B Kinase Interacting Protein (IKBIP) has been reported to promote tumor progression in diverse cancers. however, the role of IKBIP in hepatocellular carcinoma (HCC) has remained unclear. Metho...

Obinutuzumab is a humanized type II anti-CD20 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity. It is widely used in B-cell malignancies and is increasingly being explored in autoimmune diseases...