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Type 2 diabetes mellitus (T2DM) is characterized by chronic metabolic dysfunction and low-grade inflammation. This study aimed to identify inflammation-associated molecular targets in T2DM and to computationally evaluate...

Abstract Background Anthropogenic pressures, including urbanisation, globalisation and climate change, have facilitated an increased risk for emergence or re-emergence of mosquito-borne diseases into regions such as the ...

Modern trends have clearly shown that artificial intelligence is no longer just a futuristic concept of the future. The dynamics of its development and the possibilities of practical application have already made it a po...

This is the first part of a special issue on the impact of Upper Pleistocene climatic and environmental change on hominin occupations and landscape use. In this part there are six contributions: Davies, W., and Nigst,...

Societal and political voices call for stronger environmental protection, biodiversity conservation, and reduced pesticide use. Integrating digital farming technologies into farming systems like strip intercropping offer...

For 25 years, the Brazilian Society of Nephrology has systematically monitored chronic dialysis care through the Brazilian Dialysis Survey, offering a unique perspective on the evolution of dialysis practices and access ...

Los datos espaciales obtenidos en el curso de las investigaciones arqueológicas desarrolladas en el partido de Puan (provincia de Buenos Aires) en los últimos 30 años fueron procesados para la elaboración de una cart...

Communities are central to social-ecological systems where environmental dynamics, development pressures, and human well-being intersect. Yet, infrastructure planning often overlooks this complexity, leading to unintende...

Abstract Background Follicular development is a prerequisite for vertebrate reproduction, and it is precisely regulated by complex genomic conformations and regulatory elements. However, the dynamic changes in the intera...

Tropical dry woodlands are key ecosystems for global biodiversity, carbon storage, and forest-based livelihoods in some of the poorest regions of the world. Many of these woodlands have been historically converted and de...

In some regions of Argentina and Brazil, the South American fruit fl y Anastrepha fraterculus (Wied.) (Diptera: Teph-ritidae) causes significant damage to crops. An efficient integrated management program requires knowle...

Los espacios verdes urbanos cumplen un rol fundamental para la conservación de aves en ciudades. Aunque el rol de los parques urbanos para conservar la diversidad de aves ha sido analizado a escala global, el análisis ...

Abstract Objective Tuberculosis (TB) remains a global health threat with an incompletely understood pathogenesis. The RNA epigenetic modification N6-methyladenosine (m6A) is a key regulator of immune responses in various...

As intervenções do grafite e da pichação na cidade criam fissuras no real que, por vezes, geram reações violentas, já que a maioria de nós tem dificuldade em lidar com fenômenos atuantes fora da dita ordem natur...

Abstract BackgroundThe Sustainable Development Goals (SDGs) aim to eradicate poverty and inequality while ensuring that all individuals enjoy good health. Among these, target 3.1 seeks to reduce the global ma...

Distribution of ungulates is regulated by natural factors, such as presence of other species, climate, and habitat variability, as well as human activities, including livestock grazing and mining. Understanding the spati...

Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood. Early immune checkpoint inhibitors hav...

Abstract The piwi-interacting RNAs (piRNAs) are essential for controlling transposable elements (TEs) activity in germ cells, yet their expression dynamics and functions during human oogenesis remain poorly understood. H...

Ecological security (ES) is a crucial indicator of regional ecosystem health and integrity, serving as a fundamental basis for formulating sustainable ecological management strategies, particularly in ecologically fragil...

Background: Barrett's esophagus (BE) represents a critical precancerous lesion arising from chronic gastroesophageal reflux disease (GERD), with significant risk of progression to esophageal adenocarcinoma. Despite advan...

Latin America exhibits one of the highest rates of biodiversity and ecosystem services (ES) loss worldwide along with a remarkable asymmetry in the access to ES benefits (ecosystem services inequality, ESI hereafter). Th...

ABSTRACT Background and Aims Bangladesh has dramatically reduced its malaria burden since 2000, confining the disease to specific geographic zones. However, the national 2030 elimination goal is now threatened by a compl...

The rapid urban-induced Land Use and Land Cover (LULC) changes threaten river health, necessitating the identification of key drivers. It becomes essential to conduct a comprehensive assessment of anthropogenic changes t...

Film studies is an academic discipline that delves into a variety of theoretical, historical, and critical viewpoints on cinema, viewing it as both an art form and a means of communication. It provides multiple approache...