Buscar recursos académicos

BackgroundAdjuvant immune checkpoint inhibitors (ICI) have improved survival in stage III cutaneous melanoma, yet many patients do not benefit. The tumor microenvironment is pivotal for durable responses; defining cellul...

Common variable immunodeficiency (CVID) is a group of heterogeneous disorders with common denominators of impaired antibody production and function and recurrent infections. Currently, prognostic biomarkers for CVID are ...

Abstract Background Lung cancer remains the leading cause of cancer-related mortality worldwide. This study aimed to develop prognostic prediction models for lung squamous cell carcinoma (LUSC) through multi-omics integr...

Abstract Folate (FA), essential for DNA synthesis, repair and methylation, is predominantly stored and metabolized in the liver. Dysregulation of folate intake and metabolism is strongly implicated in the pathogenesis of...

Interactions between communities of the gut microbiome and with the host could affect the onset and progression of metabolic associated fatty liver disease (MAFLD), and can be useful as new diagnostic and prognostic biom...

Aortic diseases (aortic aneurysm, aortic dissection, atherosclerosis) represent a substantial clinical and economic burden due to the lack of effective early diagnostic tools and mechanism-based therapies. Metabolomics, ...

Background: Renal cell carcinoma (RCC) is a highly heterogeneous malignancy lacking reliable prognostic biomarkers and effective therapeutic targets. TMEM72, a kidney-enriched protein, is dysregulated in RCC, yet its bio...

ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloido...

Background Despite expanding therapeutic options, the prognosis of lung squamous cell carcinoma (LUSC) remains poor. Immune checkpoint inhibitors benefit only a subset of patients, and epithelial–mesenchymal transition...

BackgroundArtificial intelligence (AI) has substantial potential to advance periodontal and peri- implant care through novel diagnostic, prognostic, and therapeutic opportunities. Nevertheless, the evidence is scattered ...

Objectives: Survival rates in patients with oral squamous cell carcinoma (OSCC) have failed to improve greatly over time, and novel biomarkers are urgently needed. Therefore, the aim was to evaluate the predictive abilit...

Abstract B and T lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) are emerging immune checkpoint molecules implicated in immune dysregulation during critical illness. We investigated the prognostic rel...

Abstract Immunotherapy has transformed melanoma treatment, yet only a subset of patients benefit and clinically effective biomarkers remain limited. Here, we report a comprehensive analysis evaluating CD27 as a predictiv...

Abstract Background Currently, the pathogenesis of congestive heart failure (CHF) in cats is not fully understood. Objective To identify novel biomarkers for CHF in cats caused by primary cardiomyopathy, particularly rel...

ABSTRACT Background and Aims Stroke is the most significant contributor to morbidity worldwide. Prognostication in stroke patients could lead to better planning and care and, subsequently, better outcomes. Recently, lncR...

Abstract Background Receiver Operating Characteristic (ROC) analysis is commonly used to evaluate how well biomarkers distinguish between diseased and non-diseased individuals. A very important step in this process is ch...

Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPis) are the standard of care for primary ovarian cancer (OC), yet adverse events (AEs) frequently necessitate dose modifications. The prognostic impact of ...

Liver hepatocellular carcinoma (LIHC) is an aggressive cancer associated with chronic liver disease, necessitating better biomarkers and therapies. Manganese, an essential trace element, regulates tumor development. Data...

Abstract Background Pediatric sepsis remains a leading cause of global mortality, necessitating early and accurate risk stratification. Traditional scoring systems often fail to capture the rapid, non-linear progression ...

Abstract Background Lung squamous cell carcinoma (LUSC) is one of the common pathological subtypes of non-small cell lung cancer, which poses significant treatment challenges due to poor response to conventional therapie...

BackgroundGlucocorticoid therapy in pneumonia patients confounds conventional inflammatory biomarkers, hindering accurate risk stratification. The lactate dehydrogenase-to-albumin ratio (LAR), a proposed steroid-resilien...

This mini-review aims to examine how molecular PET and immuno-PET may complement tissue-based biomarkers in gastric cancer immunotherapy by enabling whole-body assessment of target expression, stromal biology, immune eff...

Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...

Aim: Chronic liver disease (CLD) is characterized by progressive impairment of hepatic function and frequent lipid metabolism abnormalities, with reductions in high-density lipoprotein cholesterol (HDL-C) and other lipop...