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Although vaccination remains one of the most impactful interventions in contemporary public health, with consistent and widely documented reductions in morbidity and mortality, the traditional empirical development of va...

BackgroundNew vaccine approaches are needed against tuberculosis (TB). We sought to optimize mucosal immunogenicity and protective efficacy by modulating the adjuvant component and route of immunization of a next-generat...

Hepatitis B vaccine is recommended different dosage and different way from the allot of study in hemodialysis patients. We aim to investigate the effect of single and double dose hepatitis B vaccine in hemodialysis patie...

Abstract Human papillomavirus (HPV) vaccination is a safe and cost-effective strategy for preventing cervical cancer, yet uptake remains low worldwide, particularly in low- and middle-income countries (LMICs). Numerous i...

Vaccination is widely used to control foot-and-mouth disease (FMD), necessitating robust approaches for evaluating vaccine potency to ensure a consistent supply of effective and safe vaccines. Traditional (in vivo) poten...

Abstract Objective Klebsiella pneumoniae (Kp) is a clinically prevalent opportunistic pathogen, with escalating antimicrobial resistance posing substantial challenges. Current vaccine strategies are constrained by the...

Abstract Objective Helicobacter pylori (Hp) infection is prevalent worldwide and represents a risk factor for various chronic inflammatory and neoplastic gastric diseases. In recent years, lipid nanoparticles (LNPs) h...

Tuberculosis (TB) vaccine design relies on the selection of optimal antigens. However, evidence on candidate antigens is scattered across the literature and rarely linked to critical vaccine parameters, such as immune re...

Abstract Background Since the COVID-19 pandemic routine vaccination rates have dropped in Canada. Many newcomers and refugees experience significant vaccine inequities despite wide vaccine availability and COVID-19 pande...

Abstract Objective Tissue-resident memory T (TRM) cells play a key role as “immune sentinels” in mucosal immune protection. However, the molecular regulatory mechanisms underlying the formation and long-term resid...

IntroductionSalmonella enterica serovars Typhi and Paratyphi A cause millions of cases and thousands of deaths annually, predominantly affecting children in South and Southeast Asia. Following the licensure and World Hea...

IntroductionThe emergence of immune-evasive SARS-CoV-2 variants has exposed limitations in the breadth and durability of protection conferred by current Spike-based vaccines, highlighting the need for next-generation app...

Abstract Introduction Tuberculosis (TB) affects over 10 million people worldwide annually, is difficult to treat, and is a major cause of death. The M72/AS01E candidate vaccine is the first vaccine in over 100 years wit...

Abstract Understanding the kinetics of nanoparticle vaccine drainage to the lymph nodes and their residence time in these tissues is critical in vaccine development. Evaluating these parameters using conventional techniq...

Abstract Foot-and-mouth disease (FMD) is an infectious disease affecting pigs. The control of FMD in swine husbandry is very important because its outbreak results in a vast economic loss. FMD vaccination has effectively...

ABSTRACT Background and Aims Africa has significant challenges in meeting its vaccination needs, including inadequate manufacturing capacity, infrastructure deficiencies, a scarcity of experienced personnel, regulatory h...

Background Vaccine hesitancy and public adherence to health measures remain critical challenges in Slovakia, where coverage of COVID-19 vaccination has been low, and parents’ decisions regarding vaccination of their ch...

We recently identified Galectin-1 (Gal-1), a β-galactoside-binding lectin, as a novel immune regulator in neuroblastoma (NB). Here, we characterized the tolerogenic function of Gal-1 within the CD8+ T cell compartment a...

Fil: Inserra, Felipe. Universidad Maimónides; Argentina Fil: Tajer, Carlos Daniel. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina F...

Abstract Background Infectious bovine keratoconjunctivitis (IBK) in beef cattle has major welfare and production implications. Effective vaccination against IBK would also reduce antibiotic use in beef production. Object...

Forecasting vaccine demand and determining inventory policies are critical challenges in healthcare supply chains, where uncertainty poses significant operational risks. This study proposes a two-step data-driven framewo...

Porcine circovirus-associated disease (PCVAD), caused by pathogenic porcine circovirus type 2 (PCV2), remains one of the most economically devastating diseases in the global swine industry, and the continued emergence an...

Abstract Backgrounds Clinical trials are central in pandemic preparedness and response (PPR). This scoping review aimed to illustrate the landscape of COVID-19-related randomized controlled trials (RCTs), focusing on the...

Abstract BackgroundWith the advent of new vaccines, including the COVID-19 vaccines introduced during the recent pandemic, the need for near real-time active surveillance has increased to support timely regul...