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ABSTRACT Background and Aims Limited evidence suggests autoimmune thyroiditis (AT) could represent a risk factor for cervical artery dissection (CeAD). We tested the hypothesis of a positive association between AT and Ce...

Objective Metabolic syndrome increases the risk of cardiovascular diseases and diabetes. This study examined the associations of body mass index and the appendicular lean mass-to-body weight ratio with metabolic syndrome...

Abstract Background Proper eating/fasting cycle can regulate circadian rhythms, thereby influencing metabolic regulation, oxidative stress, and cognitive function. However, its association with overall health remains und...

Abstract Introduction Atrial fibrillation (AF) is a major cardiovascular complication of thyrotoxicosis but its burden and predictors are poorly described in sub-Saharan Africa. We assessed the prevalence, clinical cours...

BackgroundPrimary ciliary dyskinesia (PCD) management relies on mucociliary clearance to prevent bronchiectasis. While humoral immunodeficiencies have been reported in PCD, their clinical significance remains under-defin...

Abstract Objective The relationship between muscle function recovery and biomechanical alterations after anterior cruciate ligament reconstruction (ACLR) during high-risk movements remains unclear. This study aimed to in...

ABSTRACT The biportal endoscopic technique, known as unilateral biportal endoscopy (UBE), has emerged as an effective minimally invasive approach for managing various spinal disorders. This report presents the first docu...

ABSTRACT Background and Aim Cardiovascular diseases are the leading cause of death in both developed and developing countries, causing significant healthcare system disruptions due to inadequate access, high costs, and g...

BackgroundItchy E3 ubiquitin ligase deficiency (ITCH deficiency) is a rare monogenic immune dysregulation syndrome characterized by early-onset multisystem autoimmunity and significant morbidity and mortality. Only one p...

Adrenocortical carcinoma (ACC) is a rare malignancy with limited therapeutic options following the failure of standard adjuvant therapies. We present a 54-year-old female with stage IV cortisol-secreting ACC that progres...

The recognition of disorders of immune dysregulation, particularly those presenting with lymphoproliferation and systemic autoimmunity (International Union of Immunological Societies [IUIS] Group 4.6), has markedly incre...

Abstract Objective This study aims to evaluate the clinical features, efficacy of endoscopic therapy, and long-term prognosis in patients with ectopic papilla of Vater (EPV) located in the duodenal bulb. Methods A retros...

Abstract Background The arthroscopic posterior transseptal approach (TSA) allows improved visualization of the posterior compartment of the knee joint. However, it can be associated with increased risks particularly rega...

BackgroundAlthough drug rash with eosinophilia and systemic symptoms (DRESS) and anticonvulsant hypersensitivity syndrome are well-known complications of anti-seizure medications (ASMs), lesser-known immunologic complica...

Abstract Background Patients with hypermobile Ehlers-Danlos Syndrome (hEDS) are at risk of developing craniocervical instability (CCI). Iatrogenic causes of CCI in hEDS are underreported. We describe a case series of hED...

Objective: Renal cystic diseases consist of a broad spectrum of hereditary or acquired conditions that may lead to end stage renal disease. We aimed to evaluate our patients diagnosed as renal cystic disease in terms of ...

Interferon regulatory factor-2-binding protein-2 (IRF2BP2) is a transcriptional regulator affecting diverse cellular functions, including cell differentiation and apoptosis. It plays an important role in lymphocyte and m...

ABSTRACT To evaluate the effectiveness of percutaneous endoscopic lumbar discectomy (PELD) in the treatment of recurrent lumbar disc herniation, comparing it with conventional techniques with an emphasis on the improveme...

Emily Kutrieb,1 Derek Weycker,1 Montserrat Vera-Llonch,2 Arthur Zbrozek,3 Kevin Ottino,1 William R Lumry4 1Avalere Health, Washington, DC, USA; 2Ionis Pharmaceuticals, Boston, MA, USA; 3Ionis Pharmaceuticals, Carlsbad, C...

The Developmental Origins of Health and Disease theory describes early life as a critical window for long-term metabolic health. Accumulating evidence has identified the gut microbiota as a key mediator of early-life met...

Abstract Background Diarrhoeal diseases remain a major global health concern, particularly in low- and middle-income countries, contributing significantly to morbidity and mortality among children under five. This study ...

Background: Latent tuberculosis infection (LTBI) remains a critical reservoir for the global tuberculosis (TB) epidemic, particularly in South Asia, where high population density and socioeconomic disparities amplify its...

BackgroundAn adverse female bias exists across many autoimmune disorders, yet its underlying mechanisms, particularly the role of sex hormones, remain poorly understood. Furthermore, the physiological influence of sex ho...

Background. Human papilloma virus (HPV), the most prevalent sexually transmitted infection worldwide, and in particular HPV 6 and 11, contribute to >90% of anogenital warts (AGW) cases, and high-risk HPV serotypes cause ...