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BackgroundGATA2 deficiency results from heterozygous pathogenic variants in the GATA2 gene, which encodes a zinc-finger transcription factor essential for hematopoietic stem and progenitor cell development. It is a highl...

Surface functionalization of cellulose nanocrystals (CNCs) is commonly used to improve their dispersibility, functionality, and performance across diverse applications. However, the potential biosafety risks of these mod...

Abstract Left atrial appendage (LAA) aneurysm is a rare structural abnormality that can predispose to significant complications, including systemic embolism and complex supraventricular arrhythmias. Here, we report a 44-...

Abstract Background Systemic antibiotic administration requires repeated dosing to maintain therapeutic plasma concentrations. Controlled drug delivery systems reduce the need for continuous systemic antibiotic use by en...

Glioblastoma stem cells (GSCs) and residual tumor cells - which resist conventional therapies, drive disease recurrence, and contribute to the formation of an immunosuppressive tumor-immune microenvironment (TIME) - repr...

IntroductionMacrophage activation syndrome (MAS) is a rare, potentially fatal hyperinflammatory complication of autoimmune disease, characterized by fever, cytopenias, hyperferritinemia, and multiorgan involvement (1). I...

BackgroundAutoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity caused by loss-of-function of the AIRE gene. Lack of AIRE impairs thymic negative selection of T cells, cau...

Opioid-free Anaesthesia (OFA) for craniotomy is a method employed increasingly for intraoperative and postoperative pain management with reduced opioid side-effects. Standard opioid regimens, although best for analgesia,...

Background: Crohn’s disease (CD) and ulcerative colitis (UC) are the two major relapsing conditions of inflammatory bowel diseases. Case Report: A case of Crohn’s disease with orofacial manifestations in a 10 year ol...

BackgroundAsthma is traditionally conceptualized as a T helper 2 (Th2)-mediated inflammatory airway disease. However, increasing evidence suggests that primary immune dysregulation may underlie or phenotypically mimic as...

POEMS syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M-protein) secretion, and skin changes. Its pathogenesis is driven by plasma cell dyscrasia...

ObjectiveThis systematic review and meta-analysis aims to evaluate the effects of Tai Chi Chuan on the expression of pro-inflammatory genes IL-6, IL-1β, and TNF-α—downstream of the NF-κB pathway—in adults with chr...

Polycythemia vera (PV) is a JAK2-mutated myeloproliferative neoplasm associated with thrombotic and vascular complications. Giant cell arteritis (GCA) is a granulomatous large-vessel vasculitis that may involve the aorta...

Zi-Hong Li,* Jia-Xing Guo,* Ji-Hong Zhang, Zhi-Ling An, Xiao Liang, Li-Hua Wang, Ying-Na Bao Department of Radiotherapy, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Peopl...

BackgroundComplex inflammatory phenotypes in children can pose significant diagnostic challenges, particularly when clinical, histopathologic, and immunologic findings do not conform to established diagnoses. We present ...

IntroductionHaploinsufficiency of A20 (HA20) is a monogenic autoinflammatory disorder caused by heterozygous loss-of-function variants in TNFAIP3, resulting in dysregulated NF-κB activation. Clinical presentations are h...

This paper treats East-Central Europe as a region and investigates its common historical trajectory in the last decades. After 30 years of systemic change and 15 years of EU membership, it is high time for the re-evaluat...

BackgroundRecurrent bacterial pneumonia accompanied by atypical systemic findings may indicate an uncharacterized inborn error of immunity (IEI). We report a 10-year-old male with recurrent pneumonias, mildly low but fun...

The emergence of the Metaverse as a persistent, immersive, and interoperable digital ecosystem introduces system-level challenges in identity management, security, and privacy protection across networked extended reality...

Usually increased presence of Heat Shock Proteins (HSPs) is considered to mediate inflammation process in Oral Lichen Planus (OLP) lesions, but in contrast HSP-70 expression found to be stable or even decreased in those ...

Sexual offender treatment programs to reduce reoffending have been implemented in many countries as part of a strategy in managing this offender group. However, there are still controversies regarding their effectiveness...

ObjectiveThis systematic review and meta-analysis synthesize preclinical evidence to evaluate the therapeutic efficacy of sinomenine in rodent models of rheumatoid arthritis, and integrate current understanding of its po...

Abstract Parasitic diseases such as malaria, leishmaniasis, and schistosomiasis remain difficult to treat due to the pathogens’ complex life cycles, intracellular niches, and resistance to conventional therapies. Tradi...