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The aim of the present investigation is to improve the dissolution of poorly water soluble drug valsartan by preparing solid dispersions and also to evaluate the effect of different inert carriers on flow properties of s...

Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formu...

Metformin hydrochloride (MH), an important drug in the treatment of type II diabetes mellitus, requires multiple administration in 500-1500 mg doses/day. Sustained release gastro retentive multiparticulates of MH were pr...

Powder mixtures (1:1) of tibolone polymorphic forms I (monoclinic) and II (triclinic) and excipients have been prepared and compacted. The samples were stored at 50 °C and 90% RH for one month and subsequently were eval...

This article investigates enhancement of the dissolution profile of gliclazide, an antidiabetic drug, using the combination of solid dispersions and melt adsorption techniques. Poloxamer and PEG 6000 were utilized as hyd...

Se realizó el estudio termoanalítico del atenolol puro y de comprimidos comerciales utilizando técnicas de termogravimetría (TG) y calorimetría diferencial de barrido (DSC). El método no isotérmico fue empleado pa...

Spherical crystallization (SC) is a promising alternative for improiving micromeritic properties and dissolution rate of active pharmaceutical ingredients. In the present work spherical agglomerates of carvedilol (CAR) w...

Este informe describe los resultados de un estudio in vitro en el que fueron evaluados comprimidos de nevirapina (200 mg) de diferentes laboratorios brasileros. El producto roiginal fue la refencia, en comparación con c...

Debido a su biodegradabilidad, recientemente los polisacáridos han sido bastante estudiados para su utilización en sistemas de liberación controlada de farmacos, ya que ellos pueden ser degradados específicamente por...

The bitter taste of paroxetine hydrochloride was masked by complexation with beta cyclodextrin. Complexation of paroxetine hydrochloride with beta cyclodextrin was characterized by differential scanning calorimetry and...

The purpose of this study was to improve the meloxicam dissolution rate through its formulation into liquisolid compacts and then to evaluate the in vitro and in vivo performance of the prepared liquisolid compacts. Di...

O propósito deste estudo foi preparar, caracterizar e avaliar o comportamento de dissolução de complexos de inclusão de furosemida com β-ciclodextrina (β-CD) ou hidroxipropil-β-ciclodextrina (HP- β-CD). Os comple...

The present study utilizes approach of solid dispersions (SDs) to improve dissolution rate of Gliclazide (GLZ); a poorly water soluble anti-diabetic drug. Formulations were prepared by solvent evaporation and melt disper...

Resveratrol exhibits wide pharmacological activities, such as, anti-oxidant, anti-inflammatory, analgesic, cardio-protective, neuro-protective, chemo-preventive, chemo-therapeutic, and anti-aging. However, its aqueous so...

Se estudió la biodegradación de películas del polímero etil-vinil-alcohol -EVOH-, en fermentación semi-sólida (FSS) con el hongo Phanerochaete chrysosporium, usando como sustrato la mezcla de iguales cantidades de ...

Microspheres were prepared using the emulsion/solvent evaporation method with the aim of obtaining diclofenac sodium (DFS) prolonged release dosage forms. The effects of the drug:polymer ratio and addition of Pluronic F6...

The goal of any drug delivery system is to provide a therapeutic amount of drug (s) to the proper site in the body in order to promptly achieve and there by to maintain the desired drug concentrations during treatment. T...

Novel stable mucoadhesive chitosan microspheres were developed to explore the possibility of nasal delivery of L-dopa to avoid first pass metabolism and to improve therapeutic efficiency in treating the symptoms of parki...

Se estudió el polimorfismo de la glibenclamida, caracterizándose cuatro formas cristalinas anhidras identificadas como: monoclínica centrada en la base (polimorfo IV), monoclínica simple (polimorfo III), ortorrómbic...

Sodium alginate microspheres of domperidone for intranasal systemic delivery were developed to eliminate first pass metabolism, improve patient compliance and obtain improved therapeutic efficacy in treatment of migrai...

The objective of present work was to assess ion exchange resins for taste masking of Dextromethorphan Hydrobromide (DM) - a highly bitter drug. A strong cationic exchange resin (Amberlite® IRP-69) and weak cationic exch...

Debido a su biodegradabilidad varios polímeros naturales, tales como los polisacáridos, han sido propuestos como excipientes adecuados para desarrollar sistemas de liberación controlada para la administración oral. E...

Materias / palabras clave: phase equilibria, equations of state, calorimetry, thermodynamics, mixtures, kinetics; Science: Physics: Heat: Thermodynamics

Materias / palabras clave: heat and temperature, thermodynamics, calorimeters and calorimetry, thermal properties of matter, heat transfer methods, thermal exergy analysis and management; Science: Physics: Heat: Thermodynamics