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Prospective Clinical Trial of Mycophenolate Mofetil (MMF) Duration De-Escalation in Allogeneic Hematopoietic Cell Transplantation (HCT) for Inborn Errors of Immunity: Is MMF Dispensable After Reduced Intensity Conditioning, Posttransplantation Cyclophosphamide(Ptcy)-Based HCT?
Artículo
Material complementario disponible Artículo DOAJ
Prospective Clinical Trial of Mycophenolate Mofetil (MMF) Duration De-Escalation in Allogeneic Hematopoietic Cell Transplantation (HCT) for Inborn Errors of Immunity: Is MMF Dispensable After Reduced Intensity Conditioning, Posttransplantation Cyclophosphamide(Ptcy)-Based HCT?
Dimana Dimitrova et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Hematopoietic cell transplantation (HCT) offers curative potential for inborn errors of immunity (IEI) patients, who often enter HCT with significant comorbidities and disease sequelae, active infections, and/or limited ...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Comprehensive clinicopathological and prognostic analysis of primary pulmonary lymphoepithelial carcinoma: a retrospective cohort study
Artículo
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Comprehensive clinicopathological and prognostic analysis of primary pulmonary lymphoepithelial carcinoma: a retrospective cohort study
Meihong Yao et al · BMC · 2026 · ISSN 1746-1596
Abstract Background Primary pulmonary lymphoepithelial carcinoma (PPLEC) is an extremely rare subtype of lung squamous cell carcinoma (LUSC). This study aims to comprehensively characterize clinicopathological and molecu...
LCC TENDOlBhdGhvbG9neQ~~Idioma eng
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Additive anti-tumor and immunomodulatory effects of Sporoderm-removed Ganoderma lucidum spore powder and anti-PD-L1 antibody in lung cancer mice
Artículo
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Additive anti-tumor and immunomodulatory effects of Sporoderm-removed Ganoderma lucidum spore powder and anti-PD-L1 antibody in lung cancer mice
Qiong Wang et al · Springer · 2026 · ISSN 2730-6011
Abstract Background The therapeutic efficacy of programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Pow...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration
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Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration
Zhangrong Cheng et al · Wiley · 2026 · ISSN 2198-3844
ABSTRACT Intervertebral disc degeneration (IVDD) is a leading global cause of low back pain, with abnormal mechanical stress being a central contributing factor. However, the molecular mechanisms through which mechanical...
LCC TENDOlNjaWVuY2U~Idioma eng
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Perubahan morfologi sel HeLa setelah paparan ekstrak etanolik Curcuma longa
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Perubahan morfologi sel HeLa setelah paparan ekstrak etanolik Curcuma longa
Suryani Hutomo et al · faculty of dentistry universitas gadjah mada · 2017 · ISSN 2460-0164
Cell morphological changes on HeLa cells after Curcuma longa etanolik extract exposure. Curcuma is mostly found in the areas with tropical and sub-tropical climate, and is one of original plants of Southeast Asia. In Ind...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges
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Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges
Kohei Okuyama et al · BMC · 2026 · ISSN 1476-4598
Abstract Immune checkpoint inhibitors (ICIs) have fundamentally altered the therapeutic paradigm for head and neck squamous cell carcinoma (HNSCC); however, durable clinical benefit remains limited to biologically define...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Synthesis and In Vitro Cytotoxicity of Glycans-Capped Silver Nanoparticles
Tesis
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Synthesis and In Vitro Cytotoxicity of Glycans-Capped Silver Nanoparticles
Daniela Manno et al · SAGE Publishing · 2011 · ISSN 1847-9804
Silver nanostructures were successfully synthesized through a simple and "green" method using saccharides as reducing and capping agent. Transmission electron microscopy (TEM) and UV-Vis absorption were used to certify t...
LCC LCC:Materials of engineering and construction. Mechanics of materials; TENDOlRlY2hub2xvZ3k~Idioma eng
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Distinguishing adrenal metastases from benign lesions in NSCLC: the value of clinical and radiological parameters
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Distinguishing adrenal metastases from benign lesions in NSCLC: the value of clinical and radiological parameters
Alperen Akansel Çağlar et al · BMC · 2026 · ISSN 1471-2407
Abstract Background Lung cancer is the most prevalent malignancy worldwide and the leading cause of cancer-related deaths. The adrenal gland is a frequent site of metastasis in non-small cell lung cancer (NSCLC). The dif...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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The Burden of Indirect Causes of Maternal Morbidity and Mortality in the Processof Obstetric Transition: A Cross-Sectional Multicenter Study
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The Burden of Indirect Causes of Maternal Morbidity and Mortality in the Processof Obstetric Transition: A Cross-Sectional Multicenter Study
Jessica Fernandes Cirelli et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2018 · ISSN 0100-7203
Abstract Objective The aim of this study is to evaluate the burden of indirect causes of maternal morbidity/mortality in Brazil. Methods Secondary analysis of a multicenter cross-sectional study conducted in 27 refer...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Evaluation of the clinical outcome of hypercalcemia of malignancy and concurrent azotemia in dogs with lymphoma
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Evaluation of the clinical outcome of hypercalcemia of malignancy and concurrent azotemia in dogs with lymphoma
Alyssa A. Strumpf et al · Oxford University Press · 2024 · ISSN 0891-6640
Abstract Background Hypercalcemia of malignancy (HM) secondary to lymphoma in dogs has the potential to cause renal injury. Hypothesis/Objectives Characterize outcomes related to acute kidney injury (AKI) secondary to HM...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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A bibliometric analysis of the role of apoptosis in breast cancer immunotherapy from 1994 to 2024
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A bibliometric analysis of the role of apoptosis in breast cancer immunotherapy from 1994 to 2024
Xin-Yu Li et al · Springer · 2026 · ISSN 2730-6011
Abstract Background Apoptosis is a fundamental biological process and a central determinant of therapeutic response in breast cancer (BC). Resistance to immunotherapy is increasingly recognized to be driven, in part, by ...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti–PD-1 efficacy in bladder cancer
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APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti–PD-1 efficacy in bladder cancer
Chi Zhang et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract TP53 is frequently mutated in bladder cancer and is associated with aggressive disease, yet actionable strategies that also improve responses to immune checkpoint blockade remain limited. Here we show that APR-2...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Acid-mediated tumor invasion as a function of nutrient source location
Artículo
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Acid-mediated tumor invasion as a function of nutrient source location
Menchón, Silvia Adriana · American Physical Society · 2019 · ISSN 1063-651X
Cancer cells have an altered metabolism that increases acid production driving to an extracellular pH significantly lower than normal. This leads to normal cell death, and extracellular matrix degradation allowing the fo...
Idioma eng
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CS2164 combined with radiation suppressed tumor growth via γ-H2AX persistence and ROS accumulation
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CS2164 combined with radiation suppressed tumor growth via γ-H2AX persistence and ROS accumulation
Shun-li Peng et al · BMC · 2026 · ISSN 1471-2407
Abstract Background CS2164 is an oral multi-target inhibitor that targets angiogenesis-related kinases, mitosis-related kinases, and chronic inflammation-related kinases. However, the added clinical benefit of CS2164 com...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Combined Immunodeficiency Manifests from S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
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Combined Immunodeficiency Manifests from S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
Ian Cohn et al · Rockefeller University Press · 2026 · ISSN 3065-8993
S-adenosylhomocysteine (SAH) hydrolase deficiency is a rare autosomal recessive disorder caused by pathogenic variants of the gene AHCY. Loss of SAH hydrolase causes SAH accumulation and impairs the methionine/S-adenosyl...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Deciphering the role of glycolipids as emerging therapeutic targets in EMT-driven cancer progression
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Deciphering the role of glycolipids as emerging therapeutic targets in EMT-driven cancer progression
Arpita Mukherjee et al · Springer · 2026 · ISSN 2730-6011
Abstract Epithelial-to-mesenchymal transition (EMT) is a complex and dynamic cellular process during which epithelial cells lose their polarity and cell adhesion capabilities and subsequently express mesenchymal stem cel...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Dickkopf 2 serves as a novel therapeutic target and prognostic biomarker in acute myeloid leukemia targeted by evodiamine
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Dickkopf 2 serves as a novel therapeutic target and prognostic biomarker in acute myeloid leukemia targeted by evodiamine
Rui Li et al · Frontiers Media S.A · 2026 · ISSN 2296-858X
ObjectiveAcute myeloid leukemia (AML) has seen a significant increase in cases recently, often leading to a poor outlook. Dysregulated cell death is a characteristic of AML that aids in both the formation and advancement...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Disulfidptosis induced by intermittent fasting and metformin enhances the efficacy of anti-PD-1 therapy in renal cancer
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Disulfidptosis induced by intermittent fasting and metformin enhances the efficacy of anti-PD-1 therapy in renal cancer
Hongru Wang et al · BMC · 2026 · ISSN 1478-811X
Abstract PBRM1-mutant ccRCC is a subtype of ccRCC with limited treatment options. Currently, there were no effective drugs specifically targeting this mutation. Here, we discovered that PBRM1-mutant ccRCC patients with c...
LCC LCC:Medicine; LCC:CytologyIdioma eng
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Ferroptosis-immune crosstalk in CNS diseases: mechanisms and translational insights
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Ferroptosis-immune crosstalk in CNS diseases: mechanisms and translational insights
Lili Li et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Ferroptosis is a form of regulated cell death driven by iron-dependent lipid peroxidation, which plays a pivotal role in regulating the inflammatory-immune microenvironment of central nervous system (CNS) diseases. Mount...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Identification of TRPM4 related genes in LUAD by RNA seq and spatial transcriptomics
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Identification of TRPM4 related genes in LUAD by RNA seq and spatial transcriptomics
Wei-jie Yu et al · Springer · 2026 · ISSN 2730-6011
Abstract Background Sodium overload-induced cell death is a novel mode of cell death that differs from other modes and is a very promising new target for cancer therapy. In addition, sodium overload-induced cell death pl...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Integrated transcriptomic and metabolomic profiling reveals immune–metabolic crosstalk and predictive biomarkers of ligustrazine treatment response in idiopathic pulmonary fibrosis
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Integrated transcriptomic and metabolomic profiling reveals immune–metabolic crosstalk and predictive biomarkers of ligustrazine treatment response in idiopathic pulmonary fibrosis
Yu Bao et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by aberrant immune responses and tissue remodeling. Ligustrazine has multiple effects, such as enh...
LCC LCC:MedicineIdioma eng
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Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye
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Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye
Wenhui Wang et al · BMC · 2026 · ISSN 1689-1392
Abstract Background Excessive lipid accumulation in the lacrimal glands under diabetic conditions can lead to lacrimal gland dysfunction and reduced tear secretion, subsequently resulting in ocular surface inflammation, ...
LCC LCC:CytologyIdioma eng
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Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic
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Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic
Beltrán Hernández Irati et al · Wiley · 2021 · ISSN 2192-8614
Nanobody-targeted photodynamic therapy (NB-PDT) has been developed as a potent and tumor-selective treatment, using nanobodies (NBs) to deliver a photosensitizer (PS) specifically to cancer cells. Upon local light applic...
LCC TENDOlBoeXNpY3M~Idioma eng
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Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt
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Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt
Martha Ghebreselassie et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract The well-established tumor suppressor, Breast Cancer Susceptibility Gene 1 (BRCA1), has been implicated in lipid metabolism and in paradoxically promoting hepatocellular carcinoma (HCC); yet its mechanistic rol...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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