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Background. Type 2 diabetes is a chronic metabolic disorder associated with impaired insulin secretion and insulin resistance, leading to persistent hyperglycemia and multiple complications. Despite advances in pharmacot...

In today’s conditions of growing anthropogenic pressure on aquatic ecosystems, the problem of heavy metal accumulation, including cobalt ions, is becoming particularly relevant. Cobalt ions can enter aquatic environmen...

Phthalate plasticizers, especially diethyl phthalate (DEP), are linked to metabolic disorders, while their precise role and mechanism in diabetic nephropathy (DN) pathogenesis remain unclear. Here, we integrated transcri...

The gut microbiota plays a central role in modulating both immunity and metabolism. Obesity-associated microbiota configuration is a critical driver of persistent inflammatory activation and immune dysfunction, ultimatel...

The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases - with growing impact in modern societies - constitute major ris...

Genetic hemochromatosis (GH) and alpha-1 antitrypsin (AAT) deficiency (AATD)  are two autosomal recessive disorders associated with an increased risk for liver injury. Among different AATD and GH genotypes, the M-Malton...

Background: The progression of pulpitis is strongly affected by the fate of dental pulp cells, with their modes of cell death determining whether inflammation resolves or leads to irreversible necrosis. Cuproptosis, a co...

Red blood cells (RBCs), formerly viewed as mere oxygen transporters, are now acknowledged as dynamic biological entities with intricate molecular characteristics which impact their deformability, lifespan, and interactio...

The recent technologies that have led to the new field of functional genomics (how the genome of an organism regulates homeostasis and responds to stimuli) are providing a clearer understanding of how organisms interact ...

Abstract Background Gut microbiota dysbiosis is a key pathological feature closely linked to metabolic disorders and neuroinflammation. It is typically characterized by reduced levels of beneficial microbial metabolites,...

Coenzyme A (CoA) is a vital cofactor involved in energy metabolism, lipid biosynthesis, protein modification, and epigenetic regulation. Disruptions in CoA biosynthesis have been implicated in neurometabolic disorders su...

Abstract Diabetes is a metabolic disorders disease characterized by the abnormal high levels of blood sugar due to incomplete or relative deficiency of insulin secretion as well as disorders in carbohydrate, lipid and pr...

OBJECTIVE: Primary glomerular diseases or some systemic disorders such as diabetes (DM) may cause proteinuria. Irisin (IRI) is a hormone secreted as a response to physical exercise by the skeleton muscle and thought to b...

Highlights Increasing demand for plant-based dairy alternatives to support of human health and maximization of global food resources. Rich in essential amino acids and considered as power house of quality protein. They d...

Abstract Subarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies signifi...

Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it targets thioredoxin (TRX)-mediated redox regulation and glucose transporter (GLUT)-mediated metabolism. TXNIP consists o...

Abstract Osteoarthritis is an aging-related systemic disease involving the crosstalk of multiple organs/tissues in metabolism and inflammation, yet little is known about the contribution of liver and marrow adipose tissu...

Ageing, immobilization, sepsis or cachexia reduce muscle mass and function. The age-related loss, i.e. sarcopenia, contributes to frailty and results in a loss of mobility and autonomy in aging and disease. Affected ind...

Background: Perthes disease, also known as Legg-Calvé-Perthes disease (LCPD), is a paediatric orthopaedic condition that compromises the blood flow to the hip joint causing avascular necrosis of the femoral head affecti...

Hepatic manifestations of type 2 diabetes, including steatosis, represent a major complication driven by hepatic lipotoxicity and ceramide accumulation, yet few targeted interventions are available. This study investigat...

BackgroundObesity is a major risk factor for lipotoxic cardiomyopathy, a process involving lipid metabolism disorders, inflammatory responses, and mitochondrial dysfunction. Salvia miltiorrhiza (Danshen), a traditional C...

Abstract Mitochondrial diseases progressively lead to multisystemic failure with treatment options remaining extremely limited. Here, to investigate strategies that alleviate mitochondrial dysfunction, we first generate ...

IntroductionChronic spontaneous urticaria (CSU) is a clinical diagnosis managed according to American Academy of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma & Immunology (ACAAI) guide...

BackgroundGlucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that they may also develop de novo after SARS-CoV-2 infection. Neutrophil extracellular tr...